Mr Marcus Cumberbatch
Clinical Medicine, School of Medicine and Population Health
Senior Clinical Lecturer in Urology
+44 114 215 9052
Full contact details
Clinical Medicine, School of Medicine and Population Health
F Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
Clinical: Hunterian Professor 2023. Senior Clinical Lecturer and Honorary Consultant Urological Surgeon at the University of Sheffield and Sheffield Teaching Hospitals.
Areas of specialist interest: the treatment and diagnosis of renal cancer; urothelial cancer (bladder and upper tract); testicular cancer, and prostate cancer.
Educational supervision: I am the clinical, educational or academic supervisor for two residents/registrars, two PhD students, two Foundation doctors, one BMedSci student and three SSC students (Year 2 medical school)
- Research interests
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Study Principal Investigator
YorkSURE: RCT evaluating the utility of NVH dipstick testing and community-based diagnostic imaging for the screening of males at high risk from bladder and kidney cancer mortality. Grant awarded by Yorkshire Cancer Research June 2018 (£1.5 million). We are screening persons across Yorkshire, identified as being at risk of BC based on demographic information. We are in collaboration with Kings College London and the Wolfson Institute clinical trials units to roll out this study over seven years.
STAMINA: NIHR-funded RCT evaluating the best delivery of exercise to offset the side effects of ADT in men with prostate cancer. NICE has already written guidance on the benefits of exercise in men in ADT. This study seeks to answer how to deliver this within the NHS.
MASTERY: A study by Intuitive and the University of Birmingham using a data recording device to record and set metrics for robotic procedures (including robotic prostatectomy) to inform educational and proctoring goals, and assess such metrics against patient outcomes.
VISP: A study using 3-D modelling to enhance surgeon understanding of tumour and vascular anatomy during partial nephrectomy. The goal is to reduce ischaemic time and improve margin and renal function outcomes status.
Additional research experience
- Clinical: Multiple systematic reviews and meta-analyses on Urological cancers (Aug 2010 to present). This work formed the background to our 2,000-patient case-control study by identifying the occupations which are currently experiencing a higher-than-average level of bladder cancer among their employees.
- Clinical: MSc in Clinical Research. Completed 2012. I have completed modules in statistics, research methods, and randomised controlled trials, and I am currently working on economic modelling, statistics packages, and healthcare epidemiology.
- Clinical: Elected to the editorial committee for Core Surgery Journal. May 2011-2015 I acted as the speciality co-ordinator of the Urology section of this peer-reviewed journal for the previous 4 years. This work involved planning article titles, reviewing articles and ensuring timely submission. We would publish an issue every 2 months. Journal available from URL: http://www.123library.org/ejournals/core-surgery-journal
- Laboratory: Alterations of mRNA export in cancer. Aug 2011-Feb 2016. I have worked in Professor S. Wilson’s laboratory focusing on RNA export in cancer. I have interrogated the expression of Luzp4, Uif and Alyref as RNA export adaptors in a variety of human tumour cell lines and primary cancers. Currently, am investigating the effects of post-translational modifications such as ADP-ribosylation upon RNA export factor localisations and interactions. I have also developed a novel approach to observing RNA export ‘live’ in advanced luminescence microscopy work. I have supervised and mentored a third-year BSc student for a 12-week lab project.
- Clinical: A contemporary case-control study of occupations and tasks associated with bladder cancer. Aug 2011 – Present. I am conducting a case-control study of modern occupational bladder cancer. This includes a questionnaire survey/interview of 2,000 patients within my region (Sheffield) for a complete occupational (and task), smoking and risk factor history.
- Elected to the committee of BURST (British Urologist Researchers in Surgical Training) research collaborative as Treasurer in September 2015. This involved managing a budget of £5,000 or more to roll out clinical trials that will help patients across the UK. The committee was competitively elected and involved meeting with other committee members including Prof Emberton and Prof Pickard.
- Laboratory: Developing a zebrafish model of bladder and prostate cancer. Oct 2017 to present. I am supervising an Academic Clinical Fellow in Urology to complete a PhD funding application based on preliminary lab work. He is using a range of techniques including microarrays, immunohistochemistry and confocal microscopy.
- Laboratory: Ex-vivo modelling to predict response to systemic therapies. I currently co-supervise a PhD student and medical students working on the use of high-throughput drug screening using a unique ex-vivo model to inform decision-making about lines of therapy.
- Clinical: RCT evaluating if daily finasteride improves adherence to active surveillance in low and intermediate-risk prostate cancer. Funded by YCR at £1.5 million. We are in collaboration with Kings College London and the Wolfson Institute clinical trials units to role out this study across 5 years
- Clinical: RCT feasibility study assessing community-based screening for bladder cancer using novel smartphone technology to detect non-visible haematuria, and using community diagnostic hubs. Funded by YCR at £1.5 million. We are in collaboration with Kings College London and the Wolfson Institute clinical trials units to role out this study across 5 years
- Lead organizer for Sheffield Pan-surgical research days and regional uro-oncology research update days
- Publications
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Journal articles
- Protocol for the YORKSURe prospective multistage study testing the feasibility for early detection of bladder cancer in populations with high disease-specific mortality risk. BMJ Open, 13(9). View this article in WRRO
- Diagnosis, treatment, and survival from kidney cancer: real-world National Health Service England data between 2013 and 2019. BJU International. View this article in WRRO
- Analysis of the distal urinary tract in larval and adult zebrafish reveals homology to the human system. Disease Models & Mechanisms, 16(7). View this article in WRRO
- Acute haemorrhage from a large renal epithelioid angiomyolipoma: diagnostic and management considerations in a teenage patient with a rare cancer. BMJ Case Reports, 16(5), e252351-e252351.
- Epidemiology of Bladder Cancer in 2023: A Systematic Review of Risk Factors. European Urology, 84(2), 176-190.
- PD36-12 MEASURING OBJECTIVE RECOVERY OF ACTIVITY LEVELS USING WEARABLE DEVICES FOLLOWING OPEN VS INTRACORPOREAL ROBOTIC CYSTECTOMY: SECONDARY OUTCOMES ANALYSIS OF THE IROC RANDOMIZED TRIAL. Journal of Urology, 209(Supplement 4).
- Critical appraisal of decision models used for the economic evaluation of bladder cancer screening and diagnosis: a systematic review. PharmacoEconomics, 41(6), 633-650. View this article in WRRO
- Diagnosis, treatment and survival from bladder, upper urinary tract and urethral cancers: Real world findings from NHS England between 2013 and 2019. BJU International.
- Comparing objective recovery of activity levels using wearable devices in open vs. intracorporeal robotic cystectomy: An analysis of the secondary outcomes of the iROC randomized trial. European Urology, 83, S219-S220.
- Hyperthermic intravesical chemotherapy with mitomycin‐C for the treatment of high‐risk non‐muscle‐invasive bladder cancer patients. BJUI Compass.
- Nomogram predicting the probability of spontaneous stone passage in patients presenting with acute ureteric colic. BJU International.
- Social deprivation and bladder cancer: cause or effect for disparities in survival for affected women. BJU International, 130(3), 301-302.
- Effect of robot-assisted radical cystectomy with intracorporeal urinary diversion vs open radical cystectomy on 90-day morbidity and mortality among patients with bladder cancer : a randomized clinical trial. JAMA, 327(21), 2092-2103.
- Deconstructing, Addressing, and Eliminating Racial and Ethnic Inequities in Prostate Cancer Care. European Urology, 82(4), 341-351.
- Protocol for CAMUS Delphi Study: A Consensus on Comprehensive Reporting and Grading of Complications After Urological Surgery. European Urology Focus, 8(5), 1493-1511.
- Robot assisted radical cystectomy with intracorporeal urinary diversion versus open radical cystectomy: Results from the iROC prospective randomised controlled trial. European Urology, 81, S1125-S1125.
- There is a Need for a Universal Language in the Reporting and Grading of Complication and Intervention Events to Ensure Comparability and Improvement of Surgical Care. European Urology, 81(5), 440-445.
- A case of acute-colonic pseudo-obstruction (Ogilvie Syndrome) post robot-assisted radical prostatectomy. Urology Case Reports, 40.
- Systematic review of active surveillance for clinically localised prostate cancer to develop recommendations regarding inclusion of intermediate-risk disease, biopsy characteristics at inclusion and monitoring, and surveillance repeat biopsy strategy. European Urology, 81(4), 337-346.
- A longitudinal study evaluating interim assessment of neoadjuvant chemotherapy for bladder cancer. BJU International, 130(3), 306-313.
- Patient- and Tumour-related Prognostic Factors for Urinary Incontinence After Radical Prostatectomy for Nonmetastatic Prostate Cancer: A Systematic Review and Meta-analysis. European Urology Focus, 8(3), 674-689.
- Does minimally invasive surgery for bladder cancer result in unusual sites of metastasis?. Actas Urológicas Españolas (English Edition).
- The application of theranostics in different stages of prostate cancer. Future Oncology, 17(27), 3637-3644.
- ¿Puede la cirugía mínimamente invasiva resultar en sitios inusuales de metástasis?. Actas Urológicas Españolas.
- A Systematic Review of Focal Ablative Therapy for Clinically Localised Prostate Cancer in Comparison with Standard Management Options: Limitations of the Available Evidence and Recommendations for Clinical Practice and Further Research. European Urology Oncology, 4(3), 405-423.
- EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer—2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent. European Urology, 79(2), 243-262.
- EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer. Part II—2020 Update: Treatment of Relapsing and Metastatic Prostate Cancer. European Urology, 79(2), 263-282.
- Re: Olaparib for Metastatic Castration-resistant Prostate Cancer. European Urology, 79(2), 319-320.
- Orchidopexy for Testicular Torsion: A Systematic Review of Surgical Technique. European Urology Focus, 7(6), 1493-1503.
- Impact of Anaesthetist Volume on Radical Cystectomy Outcomes. European Urology Focus, 7(1), 117-123.
- Occupational bladder cancer: A cross section survey of previous employments, tasks and exposures matched to cancer phenotypes. PLoS ONE, 15(10). View this article in WRRO
- The association of cigarette smoking and pathological response to neoadjuvant platinum-based chemotherapy in patients undergoing treatment for urinary bladder cancer - A prospective European multicenter observational study of the EAU Young Academic Urologists (YAU) urothelial carcinoma working group. Surgical Oncology, 34, 312-317.
- Robotic prostatectomy after abandoned open radical prostatectomy—Technical aspects and outcomes. BJUI Compass, 1(5), 174-179.
- Reporting Radical Cystectomy Outcomes Following Implementation of Enhanced Recovery After Surgery Protocols: A Systematic Review and Individual Patient Data Meta-analysis. European Urology.
- Reporting radical cystectomy outcomes following implementation of Enhanced Recovery after Surgery (ERAS) protocols: A systematic review and individual patient data meta-analysis. European Urology Open Science, 19, e2280-e2280.
- Focal Therapy: When Nothing Is Sure, Everything Is Possible. European Urology, 78(3), 379-380.
- Cerenkov Luminescence Imaging for Surgical Margins in Radical Prostatectomy: A Surgical Perspective. Journal of Nuclear Medicine, 61(10), 1498-1499.
- Biomarkers predicting oncological outcomes of high-risk non-muscle-invasive bladder cancer. Minerva Urologica e Nefrologica, 72(3).
- PD51-11 REPORTING RADICAL CYSTECTOMY OUTCOMES FOLLOWING IMPLEMENTATION OF ENHANCED RECOVERY AFTER SURGERY (ERAS) PROTOCOLS. The Journal of Urology, 203, e1087-e1088.
- Benefits and Risks of Primary Treatments for High-risk Localized and Locally Advanced Prostate Cancer: An International Multidisciplinary Systematic Review. European Urology, 77(5), 614-627.
- Chemoablation of upper tract urothelial carcinoma. BJU INTERNATIONAL, 126(3), 327-327.
- Non-visible haematuria for the Detection of Bladder, Upper Tract, and Kidney Cancer: An Updated Systematic Review and Meta-analysis. European Urology, 77(5), 583-598.
- Biochemical Recurrence in Prostate Cancer: The European Association of Urology Prostate Cancer Guidelines Panel Recommendations. European Urology Focus, 6(2), 231-234.
- EAU-EANM-ESTRO-ESUR-SIOG Prostate Cancer Guideline Panel Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer from an International Collaborative Study (DETECTIVE Study). European Urology, 76(6), 790-813.
- Factors associated with spontaneous stone passage in a contemporary cohort of patients presenting with acute ureteric colic. Results from the MIMIC Study (A Multi-centre cohort study evaluating the role of Inflammatory Markers In patients presenting with acute ureteric Colic). BJU International. View this article in WRRO
- Epidemiology, aetiology and screening of bladder cancer. Translational Andrology and Urology, 8(1), 5-11. View this article in WRRO
- Study Protocol for the DETECTIVE Study: An International Collaborative Study To Develop Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer. European Urology, 75(4), 699-702.
- Prognostic Value of Biochemical Recurrence Following Treatment with Curative Intent for Prostate Cancer: A Systematic Review. European Urology, 75(6), 967-987.
- L’impact de l’intoxication tabagique sur la réponse à la chimiothérapie néoadjuvante à base de sels de platine chez les patients traités pour carcinome urothélial de vessie – étude prospective multicentrique. Progrès en Urologie, 28(13), 669-670.
- Epidemiology of Bladder Cancer: A Systematic Review and Contemporary Update of Risk Factors in 2018. European Urology. View this article in WRRO
- Repeat Transurethral Resection in Non–muscle-invasive Bladder Cancer: A Systematic Review [Figure presented]. European Urology, 73(6), 925-933. View this article in WRRO
- MP78-19 CIGARETTE SMOKING IS ADVERSELY ASSOCIATED WITH PATHOLOGICAL RESPONSE TO PLATINUM-BASED NEOADJUVANT CHEMOTHERAPY IN PATIENTS UNDERGOING TREATMENT FOR URINARY BLADDER CANCER - A PROSPECTIVE EUROPEAN MULTICENTER STUDY OF THE EAU YOUNG ACADEMIC UROLOGISTS (YAU) UROTHELIAL CARCINOMA GROUP. Journal of Urology, 199(4S).
- MP47-20 THE IMPACT OF CIGARETTE SMOKING ON ADVERSE PATHOLOGICAL FEATURES AND SURVIVAL IN PATIENTS UNDERGOING RADICAL CYSTECTOMY FOR UROTHELIAL CARCINOMA OF THE BLADDER - A PROSPECTIVE, EUROPEAN MULTICENTER STUDY OF THE EAU YOUNG ACADEMIC UROLOGISTS (YAU) UROTHELIAL CARCINOMA GROUP. Journal of Urology, 199(4S).
- Re: Comprehensive Molecular Characterization of Muscle Invasive Bladder Cancer. European Urology, 73(3), 479-480. View this article in WRRO
- What Is the Negative Predictive Value of Multiparametric Magnetic Resonance Imaging in Excluding Prostate Cancer at Biopsy? A Systematic Review and Meta-analysis from the European Association of Urology Prostate Cancer Guidelines Panel. European Urology, 72(2), 250-266.
- Quality of Life Outcomes after Primary Treatment for Clinically Localised Prostate Cancer: A Systematic Review. European Urology, 72(6), 869-885.
- E-cigarettes and Urologic Health: A Collaborative Review of Toxicology, Epidemiology, and Potential Risks. European Urology, 71(6), 915-923.
- EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent. European Urology, 71(4), 618-629.
- The Use of Biomarkers to Manage Men with Metastatic Prostate Cancer: One Day, But Not Yet. European Urology Focus, 2(5), 467-468.
- Reply to Wentao Liu, Xiaokun Zhao, Zhaohui Zhong's Letter to the Editor re: Marcus G. Cumberbatch, Matteo Rota, James W.F. Catto, Carlo La Vecchia. The Role of Tobacco Smoke in Bladder and Kidney Carcinogenesis: A Comparison of Exposures and Meta-analysis of Incidence and Mortality Risks. Eur Urol 2016;70:458–66. European Urology, 70(4), e106-e107.
- The Role of Tobacco Smoke in Bladder and Kidney Carcinogenesis: A Comparison of Exposures and Meta-analysis of Incidence and Mortality Risks. European Urology, 70(3), 458-466. View this article in WRRO
- The contemporary landscape of occupational bladder cancer within the United Kingdom: a meta-analysis of risks over the last 80 years. BJU International. View this article in WRRO
- Micropapillary Variant Bladder Cancer: A Bad Apple or a New Fruit?. European Urology.
- PD27-06 THE IMPACT OF CIGARETTE SMOKING AND SMOKING CESSATION ON ONCOLOGICAL AGGRESSIVENESS AT RADICAL CYSTECTOMY – A PROSPECTIVE, EUROPEAN, MULTICENTER STUDY OF THE EAU YOUNG ACADEMIC UROLOGISTS (YAU) BLADDER CANCER WORKING GROUP. Journal of Urology, 195(4S).
- Error in Data. JAMA Oncology, 1(9), 1224-1224.
- Contemporary Occupational Carcinogen Exposure and Bladder Cancer. JAMA Oncology, 1(9), 1282-1290. View this article in WRRO
- 527 N6-methyladenosine mRNA methylation in common human cancers: Identifying a potential role in androgen-resistance within prostate cancer. European Urology Supplements, 14(2), e527-e527a.
- 227 Luzp4 defines a new mRNA export pathway in cancer cells. European Urology Supplements, 14(2), e227-e227b.
- Luzp4 defines a new mRNA export pathway in cancer cells. Nucleic Acids Research, 43(4), 2353-2366. View this article in WRRO
- Contemporary occupational bladder cancer: A systematic review of current exposures. International Journal of Surgery, 10(8), S96-S96.
- Contemporary Occupational Bladder Cancer: A Systematic Review and Meta-Analysis of Recently Reported Exposures that Increase Risk. UROLOGY, 80(3), S1-S2.
- Gene of the month: GATA3. Journal of Clinical Pathology.
- Renal cell carcinoma with intra-operatively identified encapsulated intra-luminal tumour extension throughout the entire ureter. Journal of Clinical Urology, 205141582098245-205141582098245.
Conference proceedings papers
- Identification of N6-adenosine methylated RNAs by m6A-seq within prostate cancer. INTERNATIONAL JOURNAL OF UROLOGY, Vol. 23 (pp 131-131)
Posters
- PD42-02 RESULTS OF THE INTRACORPOREAL ROBOTIC VS OPEN CYSTECTOMY (IROC) MULTI-CENTRE RANDOMISED TRIAL.
Preprints
- Analysis of the Distal Urinary Tract in Larval and Adult Zebrafish Reveals Unrecognized Homology to the Human System, Cold Spring Harbor Laboratory.
- Grants
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- Wellcome Trust Medical Student Grant for my Intercalated BSc, 2005 (£1,200)
- NIHR funded Academic Clinical Fellowship, 2010 (£6,000).
- The Royal College of Surgeons of England Honorary Research Fellowship, May 2012 (£3,000).
- Wellcome Trust Clinical Research Training Fellowship, June 2012 (£211,000).
- BURST Urology, National Urology Registrar’s collaborative, from the Urology Foundation and BAUS, June 2016 (£5,000)
- NIHR Academic Clinical Lecturer stipend £1,000 per year for 4 years, Oct 2017
- Royal Society of Medicine (RSM), Ellison-Cliffe Travel Fellowship, £10,000, Dec 2018.
- Action Bladder Cancer, £2,149, to fund social inequalities in uro-oncology project. May 2019
- Finesse trial, YCR funded, apportioned income £75,000.
- Yorksure trial, YCR funded, apportioned income £225,000
- Teaching activities
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I am clinical, educational or academic supervisor for 2 residents/registrars, 2 PhD students, 2 Foundation doctors, 1 BMedSci student, and 3 SSC students (Year 2 medical school).
Simulation training: I took part as an active faculty member on the Trent Foundation School Final Year Medical Student Advanced Simulation Course, Queens Medical Centre. Dec 2009.
Student Selected Component (SSC) Supervisor for Sheffield Medical School: I have been a mentor and tutor for students undertaking a student-selected component (SSC) in Academic Urology. This involved taking them through research basics, facilitating their involvement in a clinical trial and giving a lecture on Epidemiology. Dec 2011-Present. I have also facilitated phase 1 students’‘Critical Analysis’ module. Jan 2012-Feb 2012.
Undergraduate Teaching Lead for Year 2,4 and 5 at the University of Sheffield. Jul 2013-Aug 2014: I was the chief organiser and conductor of weekly teaching on surgical principles of histories and examinations, urological emergencies and conditions to phase 2, phase 3b and phase 4 Sheffield Medical School students at the Royal Hallamshire Hospital. This involved fortnightly tutorials and yearly lectures.
Local journal club organiser at Mid Yorks Hospitals 2016-2017: Registrar’s teaching: ongoing throughout higher surgical training. 2016-present
Faculty member at EAU London 2017 ESU course on writing a introduction and methods and Updates in prostate cancer basic science.
Faculty member EAU Copenhagen 2018 ESU course on conducting a systematic review.
- Professional activities and memberships
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Reviewer for the following journals:
- European Urology, Jan 2016-present
- J Urol, Jan 2018-present
- J Clin Urol Jan 2019-present
- BJUi 2020-present
Memberships
- Royal College of Surgeons of England (RCSEng)
- British Association of Urological Surgeons (BAUS)
- European Association of Urology (EAU): Prostate cancer guidelines member (associate)
- Medical Defence Union (MDU)
Management roles: Foundation doctor lead and rota manager. Prostate cancer pathway lead. Central uro-oncology MDT (cancer board) lead for the region.
Medico-legal work: I currently prepare 1-2 reports per month. I work 75:25 in favour of claimant representation.
Co-host and co-founder of the TBBBpodcast: A universally available educational podcast evaluating all aspects of surgery, focusing on urological issues (https://www.buzzsprout.com/2042735/episodes). Available on Spotify. Twitter: @tbbbpodcast