Generation of Preference-based Indices for Dementia From The DEMQOL and DEMQOL-Proxy For Use In Economic Evaluation (DEMQOL-5D and DEMQOL-P-4D)
The aim of this project is to produce condition specific preference based measures for dementia for both patient and carer report. The measures will subsequently be used in the cost utility analysis of dementia specific interventions.
The health state classification systems have been developed from the DEMQOL system. These consist of a patient measure (DEMQOL) and a carer measure (DEMQOL-Proxy) of health related quality of life in dementia. To develop the classification systems, psychometric and Rasch analysis have been applied to the measures. Following the analysis a 5 dimension classification system was produced for the patient measure (DEMQOL-5D) and a 4 dimension classification was produced for the proxy instrument (DEMQOL-P-4D).
To produce the preference weights, the classification systems have been valued by a representative sample of the UK general population. The results are currently geing analysed. A valuation study with dementia patients and carers of people with dementia is also underway.
These measures will be applied to new and existing data DEMQOL and DEMQOL-Proxy data to assess the cost effectiveness of treatments and care arrangements for dementia.
Mulhern B, Smith SC, Rowen D, Brazier J, Knapp M, Lamping DL, Loftus V, Young TA, Howard RJ, Banerjee S. (2010). Improving the measurement of QALYs in dementia: Developing patient- and carer-reported health state classification systems using Rasch analysis. HEDS Discussion Paper 10/13
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