Professor Claire Lewis
Professor of Molecular & Cellular Pathology &
Head, Academic Unit of Inflammation & Tumour Targeting
Department of Infection and Immunity
Floor E, University of Sheffield Medical School
Beech Hill Road
Sheffield
S10 2RX
UK
Telephone: +44 (0)114 271 2903
Fax: +44 (0)114 271 1711
Email: claire.lewis@sheffield.ac.uk
Secretary: Paula Blackwell
Tel: +44 (0)114 271 2501
Fax: +44 (0)114 271 1711
Email: paula.blackwell@sheffield.ac.uk
*Work by the Unit reported in April 2008 by the UK press
Previous Appointments
- Pharmacia & Upjohn Edward Rotan Visiting Professor, MD Anderson Cancer Center, Houston, USA. 2003 (non-stipendiary).
- Reader in Molecular & Cellular Pathology, Department of Pathology, University of Sheffield. 1998-9
- Senior Lecturer in Molecular & Cellular Pathology, Department of Pathology, University of Sheffield. 1996-8.
- Senior Research Fellow and then University Research Lecturer in Experimental Pathology, Nuffield Department of Pathology & Bacteriology, University of Oxford. 1991-6. [Post held in conjunction with a Senior Research Fellowship at Keble College, Oxford].
- CRC Postdoctoral Research Fellow, Nuffield Department of Pathology & Bacteriology, University of Oxford. 1988-91.
- Wellcome Trust Postdoctoral Research Fellow, Department of Human Anatomy & Genetics, University of Oxford. 1985-8.
Association with Journals
- Member of the Editorial Board, International Journal of Cancer, 2009 onwards.
- Associate Editor, International Journal of Experimental Pathology, 1996 - present.
- Member of the Editorial Board, Angiogenesis, 2002 - present.
Association with Grant-Awarding Bodies
- Member, AACR Basic Cancer Research Grants Scientific Review Committee (2010)
- Member, Scientific Advisory Board, Cancer Section of EU Framework 7 (2007-2009).
- Chair, BBSRC Review Panel in Interdisciplinary Research (2005).
- MRC College of Experts - Molecular and Cellular Medicine Board, (2004 - current).
- EPSRC Peer Review College (2006 - 2009).
- Member, Scientific Advisory Board, Breast Cancer Campaign (1999-2002).
Membership of Learned Societies
- American Association for Cancer Research.
- British Association for Cancer Research.
- International Cytokine Society.
- British Society for Immunology.
- Pathological Society of Great Britain & Ireland.
- Society for Leukocyte Biology.
Publications (selected)
Books:
Staton CA, Lewis CE and Bicknell R. (2007). Angiogenesis assays: a critical appraisal of current techniques. Wiley and Sons, London, UK.
Burke B and Lewis CE (Eds). (2002). The Macrophage. 2nd edition. Oxford University Press, Oxford, U.K.
Lewis CE, O'Brien R and Barraclough, J (Eds). (2002). The Psychoimmunology of Human Cancer. 2nd edition. Oxford University Press, Oxford, U.K.
Bicknell R, Lewis CE and Ferrara N (Eds). (1997). Tumour Angiogenesis. Oxford University Press, Oxford, U.K.
Pusztai L, Lewis CE and Yap E (Eds). (1995). Regulation of the Proliferation of Neoplastic Cells. Oxford University Press, Oxford, U.K.
Lewis CE, O'Sullivan C and Barraclough, J (Eds). (1994). The Psychoimmunology of Human Cancer. Oxford University Press, Oxford, U.K.
Lewis CE and McGee JO'D (Eds) (1992). The Natural Killer Cell. Oxford University Press, Oxford, U.K.
Lewis CE and McGee JO'D (Eds) (1992). The Macrophage. Oxford University Press, Oxford, U.K.
Selected publications (since 2000):
Coffelt SB, Lewis CE, Naldini L, Brown JM, Ferrara N and De Palma M. (2009). Elusive identities and overlapping phenotypes of pro-angiogenic myeloid cells in tumors. Am. J. Pathol. (in press).
Krajewska E, Lewis CE, Chen Y-Y, Welford A, Tazzyman T and Staton CE. (2009). A novel fragment derived from the beta chain of human fibrinogen, beta 43-63, is a potent inhibitor of activated endothelial cells in vitro and in vivo. Brit. J. Cancer 102(3):594-601.
Fang H-Y, Hughes R, Murdoch C, Coffelt S, Biswas SK, Harris AL, Johnson RS, Imityaz HZ, Simon MC, Fredlund E, Greten R, Rius J and Lewis CE. (2009). Hypoxia inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood 114:844-59.
Coffelt SB, Hughes R and Lewis CE. (2009). Tumor-associated macrophages: effectors of angiogenesis and tumor progression. Biochim Biophys Acta 1796:11-8.
Hagemann T, Biswas SK, Lawrence T, Sica A and Lewis CE. (2009). Regulation of macrophage function in tumors: the multifaceted role of NF-kB. Blood 113:3139-46.
Ryan RM, Green J, Williams PJ, Tazzyman S, Hunt S, Harmey JH, Kehoe SC and Lewis CE (2009). Bacterial delivery of a novel cytolysin to hypoxic areas of solid tumors. Gene Therapy 16:329-39.
Murdoch C, Muthana M, Coffelt S and Lewis CE, (2008). The Role of Myeloid Cells in the Promotion of Tumour Angiogenesis. Nature Reviews Cancer 8:618-31.
Elbarghati L, Murdoch C and Lewis CE. (2008). Effects of hypoxia on transcription factor expression in human monocytes and macrophages. Immunobiology 213: 899–908.
Muthana M, Scott SD, Farrow N, Morrow F, Murdoch C, Grubb S, Brown NJ, Dobson J & Lewis CE. (2008). A novel magnetic approach to enhance the efficacy of cell-based gene therapies. Gene Therapy 15(12):902-10.
Pahler JC, Tazzyman S, Erez N, Chen YY, Murdoch C, Nozawa H, Lewis CE and Hanahan D. (2008). Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response. Neoplasia 10:329-40.
Tazzyman S, Lewis CE & Murdoch C. (2008). Neutrophils: key mediators of tumour angiogenesis. Int. J. Exp. Pathol. 90:222-31
Larsen M, Tazzyman S, Lund E, Junker N, Lewis CE, Kristjansen PEG and Murdoch C. (2008). Hypoxia-induced secretion of macrophage migration inhibitory factor from MCF-7 breast cancer cells is regulated in a hypoxia-inducible factor-independent manner. Cancer Lett. 265(2):239-49.
Biswas SK, Sica A & Lewis CE. (2008). Plasticity of Macrophage Function during Tumor Progression: Regulation by Distinct Molecular Mechanisms. J. Immunol. 180:2011-2017.
De Palma M, Murdoch C, Venneri MA, Naldini L & Lewis CE. (2007). Tie2-expressing Monocytes: Regulation of Tumor Angiogenesis and Therapeutic Implications. Trends in Immunol. 28: 519-524.
Lewis CE, De Palma M and Naldini L. (2007). Tie2-expressing Monocytes and Tumor Angiogenesis: Regulation by Hypoxia and Angiopoietin-2. Cancer Res. 67:8429-32.
Murdoch C, Tazzyman S, Webster S and Lewis CE (2007). Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. J. Immunol,178(11): 7405-11
Staton CA, Stribbling SM, Garcia-Echeverria C, Bury JP, Tazzyman S, Lewis CE, Brown NJ. (2007). Identification of key residues involved in mediating the in vivo anti-tumor/anti-endothelial activity of Alphastatin. J Thromb Haemost. 5(4):846-54.
Webb SD, Owen MR, Byrne HM, Murdoch C, Lewis CE. (2007). Macrophage-Based Anti-Cancer Therapy: Modelling Different Modes of Tumour Targeting. Bull Math Biol. 69:1747-76.
Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, O'brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Lewis CE, Wharton SB. (2007). White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses. Neuropathol Appl Neurobiol. 33:410-9.
Lewis CE and Pollard JW. (2006). Distinct role of macrophages in different tumor microenvironments. Cancer Res. 66: 605-612.
Bingle L, Lewis CE, Corke KP, Reed MWR and Brown NJ. (2006). Macrophages promote angiogenesis in human breast tumour spheroids in vivo. Brit. J. Cancer 94:101-7.
Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB, Shaw PJ, O'Brien JT and Ince PG. (2006). White matter lesions in an unselected cohort of the elderly. Molecular pathology suggests origin from chronic hypoperfusion injury. Stroke 37(6):1391-8.
Brockington A, Wharton SB, Fernando M, Gelsthorpe CH, Baxter L, Ince PG, Lewis CE and Shaw PJ. (2006). Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol. 65:26-36.
Murdoch C, Muthana M and Lewis CE. (2005). Hypoxia regulates macrophage functions in inflammation. J. Immunol. 175:6257-63.
MacRae EJ, Giannoudis A, Ryan R, Brown NJ, Hamdy FC, Maitland N and Lewis CE. (2005). Gene therapy for prostate cancer: current strategies and new cell-based approaches. Prostate 66(5):470-94
Ryan RM, Green J and Lewis CE. (2005). Use of bacteria in anti-cancer therapies. BioEssays 28:84-94.
Lewis CE & Murdoch C. (2005). Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am. J. Pathol. 167: 627-635.
Murdoch C & Lewis CE. (2005). Macrophage migration and gene expression in response to tumour hypoxia. Int. J. Cancer 117(5):701-8.
Murdoch C, Giannoudis A and Lewis CE. (2004). Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 104:2224-34.
Peters CL, Morris CJ, Mapp PI, Blake DR, Lewis CE and Winrow VR. (2004). The transcription factors hypoxia-inducible factor 1alpha and Ets-1 colocalize in the hypoxic synovium of inflamed joints in adjuvant-induced arthritis. Arthritis Rheum. 50:291-6.
Staton CA, Brown NJ, Rodgers GR, Corke KP, Tazzyman S, Underwood JCEU and Lewis CE. (2004). Alphastatin, a 24 amino acid fragment of human fibrinogen, is a potent new inhibitor of activated endothelial cells in vitro and in vivo. Blood 103:601-6.
Ameri K, Lewis CE, Raida M, Sowter H, Hai T and Harris AL. (2004). Anoxic induction of ATF-4 via HIF-1 independent pathways of protein stabilisation in human cancer cells. Blood 103: 1876-82.
Staton CA, Stribbling SM, Tazzyman S, Hughes R, Brown NJ and Lewis CE. (2004). Current methods for assaying angiogenesis in vitro and in vivo. Int J Exp Pathol. 85:233-48.
Owen MR, Byrne HM and Lewis CE. (2004). Mathematical modelling of the use of macrophages as vehicles for drug delivery to hypoxic tumour sites. J Theor Biol. 226:377-91.
Daly ME, Makris A, Reed M and Lewis CE. (2003). Hemostatic regulators of tumor angiogenesis: A source of anti-angiogenic agents for cancer treatment? J. Natl. Cancer Inst. 95(22):1660-73.
Burke B, Giannoudis A, Corke KP, Gill D, Wells M, Ziegler-Heitbrock L and Lewis CE. (2003). Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy. Am. J. Pathol 163(4):1233-43.
Franks SJ, Byrne HM, Mudhar HS, UnderwoodJCE and C. E. Lewis. (2003). Mathematical modelling of comedo ductal carcinoma in situ of the breast . Math. Med. & Biol. 20: 277-308.
Franks SJ, Byrne HM, King JR, Underwood JCE and Lewis CE. (2003). Modelling the early growth of ductal carcinoma in situ of the breast. J. Math. Biol. 47:424-52.
Breward CJ, Byrne HM and Lewis CE. (2003). A multiphase model describing vascular tumour growth. Bull. Math. Biol. 65: 609-40.
Ameri K, Burke B, Lewis CE and Harris AL (2002). Regulation of a rat VL30 element in human breast cancer cells in hypoxia and anoxia: role of HIF-1. Brit. J. Cancer 87, 1173 - 1181.
Brown NJ, Staton CA, Rodgers GR, Corke KP, Underwood JCE & Lewis CE. (2002). Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of murine tumours in a syngeneic murine model. Brit. J. Cancer 86: 1813-16.
Burke B, Sumner S, Maitland N& CE Lewis (2002). Macrophages in gene therapy: cellular delivery vehicles and in vivo targets. J. Leuk. Biol. 72: 417-428.
Breward CJ, Byrne HM and Lewis CE. (2002). The role of cell-cell interactions in a two-phase model for avascular tumor growth. J. Math. Biol. 45:125-152.
Bingle L, Brown NJ and Lewis CE. (2002). The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J. Pathol. 196: 254-265.
Burke B, Ameri K, Mahon PC, Harris AL and Lewis CE. (2002). Macrophages in gene therapy. In: `The Macrophage´. 2nd edition. In Burke B and Lewis CE (Eds). Oxford University Press, Oxford, U.K (in press).
Burke B, Tang N, Corke KP, Tazzyman D, Ameri K, Wells M and Lewis CE. (2002). Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy. J Pathol. 196:204-12.
Kelly CE, Leek RD, Byrne HM, Cox SM, Harris AL and Lewis CE. (2002). Modelling macrophage infiltration into avascular tumours. J. Theor. Med. 4:21-38.
Breward CJW, Byrne HM and Lewis CE (2001). Modelling the interactions between tumour cells and a blood vessel in a microenvironment within a vascular tumour. Euro. J. Appl. Math. 12: 529-556.
Bootle-Wilbraham CA, Tazzyman S, Thompson WD, Stirk CM and Lewis CE. (2001). Fibrin fragment E stimulates the proliferation, migration and differentiation of human microvascular endothelial cells in vitro. Angiogenesis 4:269-275.
Hehlgans T, Seitz C, Lewis CE and Mannel. (2001). Hypoxic upregulation of TNF receptor type 2 expression involves NF-IL-6 and is independent of HIF-1 or HIF-2. J. Interferon Cytokine Res. 21(9):757-62.
Crowther M, Brown NJ, Bishop EB and Lewis CE. (2001). Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors. J. Leukoc. Biol. 70: 478-490.
Donovan D, Brown NJ, Bishop ET and Lewis CE. (2001). Comparison of three in vitro human `angiogenesis´ assays with capillaries formed in vivo. Angiogenesis 4(2):113-21.
Hollander AP, Corke KP, Freemont AJ and Lewis CE. (2001). Expression of HIF-1alpha by macrophages in the rheumatoid synovium: implications for targeting therapeutic genes to the inflamed joint. Arthrtitis & Rheumat. 4(7):1540-4.
Gammack D, Byrne HM and Lewis CE (2001). Estimating the selective advantage of mutant p53 tumour cells to repeated round of hypoxia. Bull. Math. Biol. 63:135-166.
Bootle-Wilbraham CA, Tazzyman S, Marshall JM and Lewis CE (2000). Fibrinogen E-fragment inhibits the migration and tubule formation of human dermal microvascular endothelial cells in vitro. Cancer Res. 60: 4719-24.
Lewis J, Landers R, Underwood JCE, Harris AL and Lewis CE. (2000). Expression of VEGF by macrophages is upregulated in avascular areas of breast carcinomas. J. Pathol. 192:150-8.
Griffiths L, Binley K, Iqball S, Kan O, Maxwell P, Lewis CE, Harris AL, Kingsman S. and Naylor S. (2000). The macrophage- a novel system to deliver gene therapy to pathological hypoxia. Gene Therapy 7:255-62.
Burke B, Lewis JS and Lewis CE. (2000). Cytokine production by individual cells. In: Cytokine Cell Biology. F.R. Balkwill (Ed). Oxford University Press, Oxford.
Leek RD, Hunt NC, Royds JR, Landers RJ, Lewis CE and Harris AL (2000). Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer. J. Pathol. 190:430-36.
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