Professor Steve Winder
Professor of Molecular Cell Biology
Director: MSc in Stem Cell & Regenerative Medicine
Department of Biomedical Science
The University of Sheffield
Western Bank
Sheffield S10 2TN
United Kingdom
email : s.winder@sheffield.ac.uk
Tel: +44 (0) 114 222 2332
Room: B2 06 Florey building
Career history
- Present: Professor of Molecular Cell Biology, Department of Biomedical Sciences, Department, University of Sheffield, Sheffield UK
- 2003-2005: Reader, Department of Biomedical Sciences, University of Sheffield, Sheffield UK
- 1999-2003 : Lecturer (99-01) Reader (02-03), University of Glasgow
- 1995-1999 : Wellcome Trust Fellow, University of Edinburgh,
- 1992-1995 : Staff Scientist, Laboratory of Molecular Biology, Cambridge - Advisor, Jake Kendrick-Jones
- 1988-1992: Postdoctoral Fellow, Biochemistry, University of Calgary, Advisor - Mike Walsh.
- 1994-1998 : PhD, University of Reading, Supervisor - Isabel Forsyth
Research interests
The main research focus of my group is centered around understanding the normal functions of the cell adhesion and signalling adaptor protein dystroglycan and in diseases such as muscular dystrophy and cancer. In particular we are investigating the regulation of the actin cytoskeleton, adhesion mediated signalling and cell motility and invasion using molecular cell biology and transgenic approaches.
Read more on research in the Winder laboratory
Activities and distinctions
- Member of Editorial Boards of: International Journal of Cell Biology, Journal of Biomedicine and Biotechnology, Advanced Studies in Biology, Landes Bioscience, also member of Biochemical Journal Editorial Advisory Panel, and Board of Protein Modules Consortium.
- Catalan Agency for Health Technology Assessment and Research grant review committee member. Regular grant reviewer for BBSRC, Welcome Trust, Telethon Italia and Asociation Française Contre les Myopathies.
- Invited talks at FASEB Summer Research Conference Snowmass USA; EMBO Workshop on 'Coiled coils collagen and co-proteins' Alpbach, Austria; ESF Conference on ‘Functional Protein Modules’ Seefeld, Austria; British Society for Cell Biology Annual Meeting, York, England.
- Invited peer reviewed reviews in Trends in Cell Bioloy, Current Opinion in Cell Biology and Trends in Biochemical Science. Editor and author of Molecular Mechanisms of Muscular Dystrophies, Landes Bioscience.
Funding
Recent publications
Sarkis J, Vié V, Winder SJ, Renault A, Le Rumeur E, Hubert JF
Resisting sarcolemmal rupture: dystrophin repeats increase membrane-actin stiffness.
FASEB J. 2012 Oct 2. [Epub ahead of print]
Mitchell A, Mathew G, Jiang T, Hamdy FC, Cross SS, Eaton C, Winder SJ.
Dystroglycan function is a novel determinant of tumor growth and behavior in prostate cancer.
Prostate. 2012 Sep 19. doi: 10.1002/pros.22581. [Epub ahead of print]
Miller G, Moore CJ, Terry R, La Riviere T, Mitchell A, Piggott R, Dear TN, Wells DJ, Winder SJ.
Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse.
Hum Mol Genet. 2012 Oct 15;21(20):4508-20. Epub 2012 Jul 18.
Moore CJ, Winder SJ.
The inside and out of dystroglycan post-translational modification.
Neuromuscul Disord. 2012 Nov;22(11):959-65. doi: 10.1016/j.nmd.2012.05.016. Epub 2012 Jul 4.
Le Rumeur E, Hubert JF, Winder SJ.
A new twist to coiled coil.
FEBS Lett. 2012 Aug 14;586(17):2717-22. doi: 10.1016/j.febslet.2012.05.004. Epub 2012 May 11. Review.
Winder SJ, Lipscomb L, Angela Parkin C, Juusola M.
The proteasomal inhibitor MG132 prevents muscular dystrophy in zebrafish.
PLoS Curr. 2011 Nov 17;3
Parberry-Clark C, Bury JP, Cross SS, Winder SJ.
Loss of dystroglycan function in oesophageal cancer.
Histopathology. 2011 Aug;59(2):180-7.