Professor Steve Winder
Professor of Molecular Cell Biology
Director, MSc in Stem Cell & Regenerative Medicine
Department of Biomedical Science
The University of Sheffield
Sheffield S10 2TN
Tel: +44 (0) 114 222 2332
Room: B2 06 Florey building
- Present: Professor of Molecular Cell Biology, Department of Biomedical Sciences, Department, University of Sheffield, Sheffield UK
- 2003-2005: Reader, Department of Biomedical Sciences, University of Sheffield, Sheffield UK
- 1999-2003 : Lecturer (99-01) Reader (02-03), University of Glasgow
- 1995-1999 : Wellcome Trust Fellow, University of Edinburgh,
- 1992-1995 : Staff Scientist, Laboratory of Molecular Biology, Cambridge - Advisor, Jake Kendrick-Jones
- 1988-1992: Postdoctoral Fellow, Biochemistry, University of Calgary, Advisor - Mike Walsh.
- 1994-1998 : PhD, University of Reading, Supervisor - Isabel Forsyth
The main research focus of my group is centered around understanding the normal functions of the cell adhesion and signalling adaptor protein dystroglycan and in diseases such as muscular dystrophy and cancer. In particular we are investigating the regulation of the actin cytoskeleton, adhesion mediated signalling and cell motility and invasion using molecular cell biology and transgenic approaches.
Activities and distinctions
- Member of Editorial Boards of: International Journal of Cell Biology, Journal of Biomedicine and Biotechnology, Advanced Studies in Biology, Landes Bioscience, also member of Biochemical Journal Editorial Advisory Panel, and Board of Protein Modules Consortium.
- Catalan Agency for Health Technology Assessment and Research grant review committee member. Regular grant reviewer for BBSRC, Welcome Trust, Telethon Italia and Asociation Française Contre les Myopathies.
- Invited talks at FASEB Summer Research Conference Snowmass USA; EMBO Workshop on 'Coiled coils collagen and co-proteins' Alpbach, Austria; ESF Conference on ‘Functional Protein Modules’ Seefeld, Austria; British Society for Cell Biology Annual Meeting, York, England.
- Invited peer reviewed reviews in Trends in Cell Bioloy, Current Opinion in Cell Biology and Trends in Biochemical Science. Editor and author of Molecular Mechanisms of Muscular Dystrophies, Landes Bioscience.
- Martínez-Zárate AD, Martínez-Vieyra I, Alonso-Rangel L, Cerecedo D, Cisneros B & Winder SJ (2014) Dystroglycan depletion inhibits the functions of differentiated HL-60 cells. Biochemical and Biophysical Research Communications, 448(3), 274-280.
- Martínez-Zárate AD, Martínez-Vieyra I, Alonso-Rangel L, Cisneros B, Winder SJ & Cerecedo D (2014) Dystroglycan depletion inhibits the functions of differentiated HL-60 cells.. Biochem Biophys Res Commun.
- Singh SM, Bandi S, Mallela KMG & Winder SJ (2014) The actin binding affinity of the utrophin tandem calponin-homology domain is primarily determined by its N-terminal domain. Biochemistry, 53(11), 1801-1809.
- Mitchell A, Mathew G, Jiang T, Hamdy FC, Cross SS, Eaton C & Winder SJ (2013) Dystroglycan function is a novel determinant of tumor growth and behavior in prostate cancer.. Prostate, 73(4), 398-408.
- Martínez-Vieyra IA, Vásquez-Limeta A, Ortega A, Cisneros B, González-Ramírez R, Morales-Lázaro SL, Mondragón M, Mondragón R & Winder SJ (2013) A role for β-dystroglycan in the organization and structure of the nucleus in myoblasts. Biochimica et Biophysica Acta - Molecular Cell Research, 1833(3), 698-711.
- Sarkis J, Víe V, Renault A, Le Rumeur E, Hubert J-F & Winder SJ (2013) Resisting sarcolemmal rupture: Dystrophin repeats increase membrane-actin stiffness. FASEB Journal, 27(1), 359-367.
- Mathew G, Mitchell A, Down JM, Jacobs LA, Hamdy FC, Eaton C, Rosario DJ, Cross SS & Winder SJ (2013) Nuclear targeting of dystroglycan promotes the expression of androgen regulated transcription factors in prostate cancer.. Sci Rep, 3, 2792.