The University of Sheffield
Department of Biomedical Science

Professor Steve Winder

Steve WinderProfessor of Molecular Cell Biology
Director: MSc in Stem Cell & Regenerative Medicine
Department of Biomedical Science
The University of Sheffield
Western Bank
Sheffield S10 2TN
United Kingdom

email : s.winder@sheffield.ac.uk
Tel: +44 (0) 114 222 2332
Room: B2 06 Florey building

Career history

Research interests

The main research focus of my group is centered around understanding the normal functions of the cell adhesion and signalling adaptor protein dystroglycan and in diseases such as muscular dystrophy and cancer. In particular we are investigating the regulation of the actin cytoskeleton, adhesion mediated signalling and cell motility and invasion using molecular cell biology and transgenic approaches.

Read more on research in the Winder laboratory

Activities and distinctions

Funding

Recent publications

Sarkis J, Víe V, Renault A, Le Rumeur E, Hubert J-F & Winder SJ (2013)
Resisting sarcolemmal rupture: Dystrophin repeats increase membrane-actin stiffness.
FASEB Journal, 27(1), 359-367.

Martínez-Vieyra IA, Vásquez-Limeta A, Ortega A, Cisneros B, González-Ramírez R, Morales-Lázaro SL, Mondragón M, Mondragón R & Winder SJ (2013)
A role for β-dystroglycan in the organization and structure of the nucleus in myoblasts.
Biochimica et Biophysica Acta - Molecular Cell Research, 1833(3), 698-711.

Mitchell A, Mathew G, Jiang T, Hamdy FC, Cross SS, Eaton C & Winder SJ (2013)
Dystroglycan function is a novel determinant of tumor growth and behavior in prostate cancer.
Prostate, 73(4), 398-408.

Moore CJ & Winder SJ (2012)
The inside and out of dystroglycan post-translational modification.
Neuromuscular Disorders, 22(11), 959-965.

Miller G, Dear TN, Moore CJ, La riviere T, Mitchell A, Piggott R, Winder SJ, Terry R & Wells DJ (2012)
Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse
.
Human Molecular Genetics, 21(20), 4508-4520.

Le Rumeur E, Hubert J-F & Winder SJ (2012)
A new twist to coiled coil
.
FEBS Letters, 586(17), 2717-2722.

Moore CJ & Winder SJ (2012)
The inside and out of dystroglycan post-translational modification..
Neuromuscul Disord, 22(11), 959-965.

Singh SM, Molas JF, Kongari N, Bandi S, Mallela KMG, Armstrong GS & Winder SJ (2012)
Thermodynamic stability, unfolding kinetics, and aggregation of the N-terminal actin-binding domains of utrophin and dystrophin.
Proteins: Structure, Function and Bioinformatics, 80(5), 1377-1392.

Brown SC & Winder SJ (2012)
Dystroglycan and dystroglycanopathies: Report of the 187th ENMC Workshop 11-13 November 2011, Naarden, The Netherlands.
Neuromuscular Disorders, 22(7), 659-668.

Broderick MJF, Winder SJ & Bobkov A (2012)
Utrophin ABD binds to F-actin in an open conformation.
FEBS Open Bio, 2, 6-11.

Le Rumeur E, Hubert J-F & Winder SJ (2012)
A new twist to coiled coil.
FEBS Letters.

Singh SM, Molas JF, Kongari N, Bandi S, Armstrong GS, Winder SJ & Mallela KMG (2012)
Thermodynamic stability, unfolding kinetics, and aggregation of the N-terminal actin-binding domains of utrophin and dystrophin.
Proteins: Structure, Function and Bioinformatics, 80(5), 1377-1392.

Brown SC & Winder SJ (2012)
Dystroglycan and dystroglycanopathies:
Report of the 187th ENMC Workshop 11-13 November 2011, Naarden, The Netherlands. Neuromuscular Disorders.

Thompson O, Moghraby JS, Ayscough KR & Winder SJ (2012)
Depletion of the actin bundling protein SM22/transgelin increases actin dynamics and enhances the tumourigenic phenotypes of cells.
BMC Cell Biol, 13, 1.