Professor David I. Strutt
Department of Biomedical Science
The University of Sheffield
Western Bank
Sheffield S10 2TN
United Kingdom
Senior Research Fellow/Professor
Room: D36 Firth Court
Telephone: +44 (0) 114 222 2372
email : d.strutt@sheffield.ac.uk
Career history
- 2005: Professor of Developmental Genetics
- 2003-present: Wellcome Senior Fellow in Basic Biomedical Science, University of Sheffield
- 1998-2003: Lister Institute-Jenner Research Fellow, University of Sheffield
- 1997-1998: Lecturer, University of Sheffield
- 1993-1997: Postdoctoral Fellow, European Molecular Biology Laboratory, Heidelberg
- 1991-1993: Postdoctoral Fellow, Department of Anatomy, University of Cambridge
- 1988-1991: PhD, Department of Anatomy, University of Cambridge
- 1985-1988: BA Natural Sciences, University of Cambridge
Research interests
Cell polarisation is a fundamental process in the development of complex multicellular organisms. We are interested in how such polarisation is coordinated and maintained during development, with a primary interest in the roles of the Frizzled sevenpass transmembrane receptor.
Read more (link to the Centre for Developmental and Biomedical Genetics)
Activities and distinctions
- Wellcome Trust Senior Fellow in Basic Biomedical Science
- Editorial board of Current Biology
Funding
Recent publications
Thomas C, Strutt D.
The roles of the cadherins Fat and Dachsous in planar polarity specification in Drosophila.
Dev Dyn. 2012 241:27-39.
Goodrich LV, Strutt D.
Principles of planar polarity in animal development.
Development. 2011 138:1877-92. Review.
Strutt H, Warrington SJ, Strutt D.
Dynamics of core planar polarity protein turnover and stable assembly into discrete membrane subdomains.
Dev Cell. 2011 Apr 19;20(4):511-25.
Strutt D, Vincent JP.
Frizzled signaling: Gαo and Rab5 at the crossroads of the canonical and PCP pathways?
Sci Signal. 2010 3:pe43.
Brittle AL, Repiso A, Casal J, Lawrence PA, Strutt D.
Four-jointed modulates growth and planar polarity by reducing the affinity of dachsous for fat.
Curr Biol. 2010 May 11;20(9):803-10.
Strutt D.
Gradients and the specification of planar polarity in the insect cuticle.
Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a000489.
Strutt H, Strutt D.
Asymmetric localisation of planar polarity proteins: Mechanisms and consequences.
Semin Cell Dev Biol. 2009 Oct;20(8):957-63. Epub 2009 Mar 21. Review.
Strutt D.
The planar polarity pathway.
Curr Biol. 2008;18(19):R898-902.
Strutt H, Strutt D.
Differential stability of flamingo protein complexes underlies the establishment of planar polarity.
Curr Biol. 2008;18(20):1555-64.
Strutt D, Warrington SJ.
Planar polarity genes in the Drosophila wing regulate the localisation of the FH3-domain protein Multiple Wing Hairs to control the site of hair production.
Development. 2008;135(18):3103-11.