Dr Steven A Julious BSc(Hons) MSc PhD FSS FRIPH CSi CStat

Reader in Medical Statistics

Medical Statistics Group, ScHARR
The University of Sheffield
Regent Court, 30 Regent Street
SHEFFIELD S1 4DA

Tel: +44 (0) 114 222 0709
Fax: +44 (0) 114 222 0749

email : s.a.julious@sheffield.ac.uk

Biography

I graduated with a BSc(Hons) in Mathematics, Statistics and Operational Research (MSOR) from the University of Manchester Institute of Science and Technology (UMIST) and an MSc in Biometry from the University of Reading. For my PhD from University College London, which I did part time while working in industry, I investigated the issue of designing clinical trials when you have imprecise estimates to base calculations on

Previously to working for the University of Sheffield, I started my career at the University of Southampton before joining GlaxoWellcome and then SmithKlineBeecham which was GlaxoSmithKline upon me leaving.

I have an interest in all aspects of clinical trials from molecule through to marketplace. In particular, I have an interest in clinical trial design (and innovative designs) and the development of new technologies (such as quality of life scales) related to clinical trials

I have written two books: the first on early phase trials and the second on sample size.

I am based in the Health Services Research Section

Research interests

My research interest include

• Clinical trials
• Clinical trial design
• Early phase trials
• Non-inferiority
• Asthma epidemiology

Teaching activities

My teaching activities include

• Module co-ordinator for HAR6036 including Intercalated BMedSci Medical Students and RTP Training Programme
• Module co-ordinating for PAS6062 further clinical trials for the MSs in Statistic with medical applications
• Teach on the MBChB degree programme
• Teach on HAR6035

Professional activities

External to the university I am a Member of NICE appraisal Committee D. Guest editing a special issue of Pharmaceutical Statistics on Non-inferiority and Statistical Methods in Medical Research on Meta Analysis.

Within the university I am a member of the University Senate and I Chair of the Advisory Board of the Clinical Trials Research Unit (CTRU)

Current projects

Research for Patient Benefit. Evaluating cost effectiveness of computer therapy compared with usual stimulation for people with long standing aphasia: a pilot study. Palmer, R, Julious S, Enderby, P and Cooper C. £250,000, 2009.

NHS Health Technology Assessment Programme. Randomised Assessment of Treatment using Panel Assay of Cardiac markers (RATPAC). Goodacre A, Julious S, Oluboyede Y, Dixon S, Hall A, Barth J, Hassan T, Collinson P, Newby D, Gray A, Capewell S, Benger J and Coats T. HAT 06/302/19 2007 £716,500.

Key Publications

Key publications since 2008

Books

• Julious, SA. Sample sizes for clinical trials. Chapman and Hall, 2009
• Julious SA. Early phase trials. Wiley, 2010

Papers

• Senn, S, Rolfe K and Julious SA. Assessing response in clinical trials. Statistical Methods in Medical Research (DOI:10.1177/0962280210379174).
• Julious SA and Owen R. Sample size calculations for non-inferiority studies with binary outcomes. Statistical Methods in Medical Research (DOI: 10.1177/0962280210378945)
• Matcham J, Julious S, Pyke S, O’Kelly M, Todd S, Davies J, Seldrup J and Day S. Proposed best practice for statisticians in the reporting of industry sponsored clinical trials in medical journals. Pharmaceutical Statistic (DOI: 10.1002/pst.417)
• Parker SG, Oliver P, Pennington M, Bond J, Jagger C, Enderby PM, et al. Rehabilitation of older patients: day hospital compared with rehabilitation at home. A randomised controlled trial. Health Technol Assess 2009; DOI: 10.3310/hta13000
• Senn S and Julious SA. Assessing the repeatability of response in clinical trials. Statistics in Medicine 2009 28:3189-3209
• Julious SA and Wang SJ. Issues with indirect comparisons in clinical trials particularly with respect to non-inferiority trials. DIJ 2008: 42(6): 625-33
• Julious SA and Mullee MA. Issues with using baseline in a last observation carried forward analysis. Pharmaceutical Statistics 2008 7(2): 142-6