The 3CPO study
A randomised controlled trial of continuous positive airway pressure (CPAP) versus non-invasive ventilation (NIV) versus standard treatment for acute cardiogenic pulmonary oedema.
Main findings
In patients with acute cardiogenic pulmonary oedema, non-invasive ventilation induces a more rapid improvement in respiratory distress and metabolic disturbance, but has no effect on short-term mortality.
There were no major differences in treatment efficacy or safety between the two non-invasive ventilation modalities of CPAP and NIPPV.
Publications
Gray A, Goodacre S, Newby DE, Masson M, Sampson F and Nicholl J on behalf of the 3CPO triallists. Non invasive ventilation in acute cardiogenic pulmonary edema. N Engl J Med 2008:359;142-151.
N Engl J Med 2008:359;142-151.
Browning J, Atwood B, Gray A on behalf of the 3CPO trial group. Use of non-invasive ventilation in UK emergency departments. Emerg Med J 2006;23:920-921.
Conference presentations
Mark Elliott on behalf of the 3CPO Research Team. Non-invasive ventilation in patients with acute cardiogenic pulmonary oedema: the 3CPO trial (a multicentre randomised controlled trial). The British Thoracic Winter Meeting, London, December 2007.
Gray A, Goodacre S, Newby DE, Masson M, Sampson F & Nicholl J. Efficacy of non-invasive ventilation in patients with acute cardiogenic pulmonary oedema: the 3CPO trial. The College of Emergency Medicine Autumn Conference, Sheffield, September 2007.
Gray A, Goodacre S, Newby DE, Masson M, Sampson F & Nicholl J. Efficacy of non-invasive ventilation in patients with acute cardiogenic pulmonary oedema: the 3CPO trial. 4th Mediterranean Emergency Medicine Conference, Sorrento, September 2007.
Gray A, Goodacre S, Newby DE, Sampson F, Nicholl J, Masson M on behalf of the 3CPO trial investigators. Efficacy of non-invasive ventilation in patients with acute cardiogenic pulmonary oedema: the 3CPO trial. European Society of Cardiology Congress Vienna, September 2007.