The University of Sheffield
Health Economics and Decision Science

Discussion Papers

This series is intended to promote discussion papers in progress. The Views expressed are those of the authors, and therefore should not be quoted without their permission. However, comments are welcome and we ask that they be sent direct to the corresponding author. 

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  1. AkiTsuchiya

    Childcare, breadwinning and mortality in the Swedish parental cohort of 1988/89

    The "gender system" that assigns the breadwinner role to fathers and the caring roles to mothers may contribute to the gender gap in longevity. This study examines the statistical association between the division of parental roles and subsequent mortality of a population of all Swedish men and women who had their first child together in 1988/89 (over 100 thousand couples).

    A.Tsuchiya, A.Mansdotter, M.Backhans, J.Hallqvist, M.Lundberg, A.Lundin, L.Lindholm

  2. eva k

    The identification and review of cost effectiveness model parameters: a qualitative study

    Health economic models are developed as part of the health technology assessment process in order to determine whether health interventions represent good value for money. The information needs for the model require the use of other types of information beyond clinical effectiveness evidence in order to populate the model parameters. We conducted a series of focus groups with UK HTA experts to explore some of the issues associated with identifying and reviewing this evidence.
    Key issues raised by the focus group respondents included the need for effective communication and teamwork throughout the model development process, the importance of using clinical experts as well as the need for transparent reporting of methods and decisions.

    M Essat, P Tappenden, E Kaltenthaler S Paisley

  3. Bmulhern

    A comparison of three binary choice methods for health state valuation

    Binary choice methods for the valuation of health states have increased in popularity in recent years.

    In this paper we use CAPI methods to assess the validity and acceptability of binary choice versions
    of TTO, LT-TTO and DCETTO.

    B Mulhern, A Tsuhiya, N Devlin, K Buckingham, D Rowen, J Brazier

  4. Nick Latimer

    Adjusting survival time estimates to account for treatment switching in randomised controlled trials

    Adjusting survival time estimates to account for treatment switching in randomised controlled trials – a simulation study.


    Treatment switching commonly occurs in clinical trials of novel interventions, particularly in the advanced or metastatic cancer setting, which causes important problems for health technology assessment. It is unclear which methods to adjust for switching are most appropriate in realistic scenarios.

    We aimed to assess statistical approaches for adjusting survival estimates in the presence of treatment switching in order to determine which methods are most appropriate in a range of realistic scenarios. We conducted a simulation study to assess the bias, mean squared error and coverage associated with alternative switching adjustment methods across a wide range of realistic scenarios.

    We found that randomisation-based methods (such as the Rank Preservinig Structural Failure Time Model) can accurately adjust for treatment switching when the treatment effect received by patients that switch is the same as that received by patients randomised to the experimental group.

    When this is not the case observational-based methods (such as Inverse Probability of Censoring Weights (IPCW)) or simple two-stage methods should be considered, although the IPCW is prone to substantial bias when the proportion of patients that switch is greater than approximately 90%. Simple methods such as censoring or excluding patients that switch should not be used.

    N Latimer, R Akehurst, A Wailoo

  5. P

    The Sheffield Type 1 Diabetes Policy Model

    The Sheffield Type 1 Diabetes Policy Model is a patient-level simulation model of type 1 diabetes and its associated complications, which was developed as part of the National Institute for Health Research Dose Adjustment for Normal Eating (DAFNE) research programme.The aim of this paper is to describe the conceptual modelling, model implementation, and model validation phases of the Sheffield Type 1 Diabetes Model development process. The model is highly flexible and has broad potential application to evaluate DAFNE, other diabetes structured education programmes, and other interventions for type 1 diabetes.

    P Thokala, J Kruger, A Brennan, H Basarir, A Duenas, A Pandor, M Gillett, J Elliot, S Heller

  6. B.Mulhern

    Using preference based measures in mental health conditions:

    Using preference based measures in mental health conditions: The psychometric validity of the EQ-5D and SF-6D. The generic preference based measures EQ-5D and SF-6D are widely used in the economic evaluation of interventions and treatments across. In this paper we assess the psychometric performance of the measures across a range of mental health conditions using existing datasets.

    B Mulhern, C Mukuria, M Barkham, M Knapp, S Byford, D Soeteman, J Brazier

  7. m hernandez

    Children’s development and parental input:Evidence from the UK Millennium Cohort Study


    Categorised under: Gurleen Popli and Monica Hernández Alava
  8. J.Brazier

    How to measure quality of life for cost effectiveness analyses in personality disorders?

    How to measure quality of life for cost effectiveness analyses in personality disorders? A systematic review.

    Categorised under: Diana Papaioannou, John Brazier and Glenys Parry
  9. CarltonJ

    Identifying Items for the Child Amblyopia Treatment Questionnaire

    Purpose: Patient reported outcome (PRO) instruments are increasingly common in both clinical practice and research. The data obtained from these instruments can be used to help inform decision-making and policy-making decisions. The methodological approaches undertaken in developing PROs is not frequently reported. Literature on the development of the descriptive systems for PROs is sparse in comparison to the assessment of the psychometric properties of such instruments. The purpose of this study is to describe the methodological approach taken in identifying potential items for the Child Amblyopia Treatment Questionnaire (CAT-QoL); a paediatric disease-specific health related quality of life instrument for amblyopia designed for children aged 4 to 7 years.

    Categorised under: Jill Carlton
  10. J.Brazier

    Examining the potential for microeconometric analysis health data sets:

    Examining the potential for microeconometric analysis health data sets: An exploratory study using the psychiatric morbidity surveys

    Categorised under: John Brazier
  11. prof J.Brazier

    A systematic review of the validity and responsiveness of EQ-5D and SF-6D for depression and anxiety

    Background: Generic preference based measures (PBM) such as the SF-6D and EQ-5D are increasingly used to inform health care resource allocation decisions. They aim to be generic in the sense of being applicable to all physical and mental health conditions. However, their applicability has not been demonstrated for all mental health conditions

    Categorised under: Diana Papaioannou, John Brazier and Tessa Peasgood
  12. Cooper2

    Incidence of advanced cutaneous malignant melanoma in the UK: a systematic review


    Categorised under: Katy Cooper, Edith Poku, Qing Wang and Urmi Bapat
  13. preston

    How much does teenage parenthood affect long term outcomes? A systematic review

    H Squires, M Hernandez, N Payne, L Blank, S Baxter, L Preston

  14. m.h

    A comparison of direct and indirect methods for the estimation of health utilities from clinical

     A comparison of direct and indirect methods for the estimation of health utilities from clinical outcomes

    M Hernández Alava, A Wailoo, F Wolfe, K Michaud