Dr Myles Jones BSc, MSc, PhD, FHEA

Address
Department of Psychology
The University of Sheffield
Sheffield S10 2TP, UK
Tel: (+44) 0114 22 26551
Fax: (+44) 0114 27 66515
Room: 2-45
Email M.Jones@sheffield.ac.uk

Qualifications

BSc Psychology (Sheffield), MSc Neuroscience (Institute of Psychiatry), PhD Psychology (Sheffield)

Teaching and administrative duties

With regard to the Undergraduate Degree in Psychology I am level 3 tutor and thus module organiser for the Research Project in Psychology (PSY 314/324/326) and Extended Essay in Psychology (PSY315). I am also module organiser for Neuroscience (PSY 219) and teach on Introduction to Psychology (PSY101); Methods and Reasoning for Psychologists (PSY104) and Neuroscience and Evolutionary Psychology (PSY 108). I am also a member of The Psychology Department Teaching Committee, Ethics Committeee and The Undergraduate Staff-Student Committee. With regard to the MSc in Cognitive and Computational Neuroscience, I am exams officer, module organiser for the Research Project in Neuroscience (PSY6321) and teach on The Fundamentals of Neuroscience (PSY6306).I am also involved in the scholarship of teaching and am a Fellow of the Higher Education Academy and a University of Sheffield, Senate Award Fellow of Excellence in Learning and Teaching.

Research Interests

Non-invasive functional neuroimaging techniques
Non-invasive functional neuroimaging techniques such as blood oxygen level dependent (BOLD) functional magnetic imaging (fMRI) are frequently used to map the cognitive architecture of the human brain. Such techniques however, do not measure neural activity per se but rather rely on the accompanying changes in blood flow, volume and oxygenation (termed `the haemodynamic response´) to infer the loci and magnitude of neural activation.

Interpreting imaging data
Characterising cerebral haemodynamics and understanding their relationship with the underlying brain activity is essential for the correct interpretation of imaging data. As an MRC PhD student, MRC research associate and now as an MRC funded principal investigator I have used optical techniques to provide direct measures of the cortical haemodynamic response.

Stimulus evoked neural activity
Additional multi-electrode recording techniques have allowed exploration of the relationship between stimulus evoked neural activity and haemodynamics across a wide range of stimulus conditions. However, the magnitude of stimulus evoked neural activity is known not only to depend on stimulus parameters but also on the amount of ongoing cortical neural activity. Ongoing activity is known to be altered during changes in attention, affect or arousal.

Neural processing
Increasingly cognitive neuroscience paradigms deliberately manipulate these states and then investigate the neural processing of subsequent stimuli with neuroimaging technology. My current research, therefore, aims to understand how the stimulus evoked neurovascular coupling relationship changes during different cortical information processing states.

Research Grants

Medical Research Council (MRC). The neurophysiological basis of prolonged negative BOLD signals – J.Berwick (PI), M.Jones, A.Kennerley, L.Boorman, C. Martin, P.Redgrave, Y. Zheng. £655,000; 06/2011-05/2014

EPSRC. "Engineering virus-like nanoparticles for targeting the central nervous system". G Battaglia (PI), S P. Armes, M. Azzouz, O. Bandmann, J. Berwick, P.G. Ince , A.J. Kennerley, M. Jones, R. Golestanian, R. Hose, R. Mead, K. Ning, A.J. Ryan, P. Shaw, R. Smallwood, D. Walker & Y. Zheng. £ 2,060,808; 05/2009-04/2012

MRC, New Investigator Award (NIA) "Neurovascular coupling during information processing states." M.Jones (PI) £197,000; 09/2006-08/2009

Travel Grants

Gordon Research Conference New Investigator Award (`Brain energy metabolism & blood flow´, Andover (NH,USA), August 17-22/08/2008) $1315

Royal Society Conference Grant (Washington DC, USA, SFN 2005) £1200

Post-Doctoral Research Associates

Dr Luke Boorman (MRC, Co-I)

Former Post-Doctoral Research Associates

Dr Mohamad Saka (MRC, PI)

PhD Students

Michael Bruyns-Haylett (TUOS Studentship, 2009-2012)

Former PhD Students

Dr Kate Bartlett (TUOS Studentship, 2005-2008, Principle Supervisor)

Dr Luke Boorman (EPSRC, 2005-2008, Co-Supervisor)

Former MSc Students

Michael Bruyns-Haylett (CCN, 2007-2008)

Janine Bijsterbosch (BICN, 2006-2007)

Activities and Distinctions

Editorial Board of

The Open Medical Imaging Journal

Reviewer for

MRC
Wellcome Trust
Journal of Neuroscience
European Journal of Neuroscience
Neuroscience
Journal of Neurophysiology
NeuroImage
Brain Connectivity
Human Brain Mapping Conference
Neurobiology of Aging
Psychopharmacology
European Neuropsychopharmacology
Transactions on Medical Imaging
Applied Optics
Frontiers in Neuroenergetics
Frontiers in Cognitive Science
Journal of Undergraduate Neuroscience Education (JUNE)
Journal of Neuroscience Methods

Research Publications

Kennerley, A.J., Harris, S., Bruyns-Haylett, M., Boorman, L., Zheng, Y., Jones, M., and Berwick, J. Early and late stimulus-evoked cortical hemodynamic responses provide insight into the neurogenic nature of neurovascular coupling. J Cereb Blood Flow Metab 32, 468-480.

Saka, M., Berwick, J., and Jones, M. (2010). Linear superposition of sensory-evoked and ongoing cortical hemodynamics. Frontiers in neuroenergetics 2.

Harris, S., Jones, M., Zheng, Y., and Berwick, J. (2010). Does neural input or processing play a greater role in the magnitude of neuroimaging signals? Frontiers in neuroenergetics 2.

Zheng, Y., Pan, Y., Harris, S., Billings, S., Coca, D., Berwick, J., Jones, M., Kennerley, A., Johnston, D., Martin, C., Devonshire, I.M., Mayhew, J. 2010. A dynamic model of neurovascular coupling: Implications for blood vessel dilation and constriction. Neuroimage. 52, 1135-1147.

Boorman, L., Kennerley, A.J., Johnston, D., Jones, M., Zheng, Y., Redgrave, P., Berwick, J. 2010. Negative blood oxygen level dependence in the rat: a model for investigating the role of suppression in neurovascular coupling. J Neurosci 30, 4285-4294.

Bruyns-Haylett, M., Zheng, Y., Berwick, J., Jones, M. 2010. Temporal coupling between stimulus-evoked neural activity and hemodynamic responses from individual cortical columns. Phys Med Biol 55, 2203-2219.

Bartlett, K., Saka, M., Jones, M. 2008. Polarographic Electrode Measures of Cerebral Tissue Oxygenation: Implications for Functional Brain Imaging. Sensors 8, 7649-7670.

Berwick, J., Johnston, D., Jones, M., Martindale, J., Martin, C., Kennerley, A.J., Redgrave, P., Mayhew, J.E. 2008. Fine detail of neurovascular coupling revealed by spatiotemporal analysis of the hemodynamic response to single whisker stimulation in rat barrel cortex. J Neurophysiol 99, 787-798.

Jones, M., Devonshire, I.M., Berwick, J., Martin, C., Redgrave, P., Mayhew, J. 2008. Altered neurovascular coupling during information-processing states. Eur J Neurosci 27, 2758-2772.

Gias, C., Jones, M., Keegan, D., Adamson, P., Greenwood, J., Lund, R., Martindale, J., Johnston, D., Berwick, J., Mayhew, J., and Coffey, P. 2007. Preservation of visual cortical function following retinal pigment epithelium transplantation in the RCS rat using optical imaging techniques. Eur J Neurosci 25, 1940-1948.

Martin, C., Jones, M., Martindale, J., and Mayhew, J. 2006. Haemodynamic and neural responses to hypercapnia in the awake rat. The European journal of neuroscience 24, 2601-2610.

Berwick, J., Johnston, D., Jones, M., Martindale, J., Redgrave, P., McLoughlin, N., Schiessl, I., Mayhew, J.E. 2005. Neurovascular coupling investigated with two-dimensional optical imaging spectroscopy in rat whisker barrel cortex. Eur J Neurosci 22, 1655-1666.

Jones, M., Berwick, J. Hewson Stoate, N., Gias, G. and Mayhew, J. 2005. The effect of hypercapnia on the neural and hemodynamic response to somatosensory stimulation. NeuroImage, 27: 609-623.

Hewson-Stoate, N., Jones, M., Martindale, J., Berwick, J. and Mayhew, J. 2005. Further nonlinearities in neurovascular coupling in rodent barrel cortex. Neuroimage 24: 565-74.

Gias, C., Hewson-Stoate, N., Jones, M., Johnston, D., Mayhew, J.E. and Coffey, P.J. 2005. Retinotopy within rat primary visual cortex using optical imaging. Neuroimage 24: 200-206.

Berwick J., Redgrave, P., Jones, M., Martindale, J., Hewson-Stoate, N., Johnston, D. and Mayhew, J. 2004. Integration of neural responses originating from different regions of the cortical somatosensory map. Brain Research, Vol 1030, No. 2, 284-293

Kong, Y., Zheng, Y., Johnston, D., Martindale, J., Jones, M., Billings, S. and Mayhew, J. 2004. A model of the dynamic relationship between blood flow and volume changes during brain activation. J Cereb Blood Flow Metab 24: 1382-92.

Devonshire, I.M., Berwick, J., Jones, M., Martindale, J., Johnston, D. Overton, P. and Mayhew, J. 2004 Hemodynamic responses to sensory stimulation are enhanced following acute cocaine administration. NeuroImage, Vol 22, No. 4, 1744-1753.

Jones, M., Hewson Stoate, N., Martindale, J., Redgrave, P. and Mayhew, J. 2004. Non-Linear Coupling of Neural Activity and CBF in Rodent Barrel Cortex, NeuroImage Vol 22, No. 2, 956-965.

Martindale, J., Mayhew, J., Berwick, J., Jones, M., Martin, C., Johnston, D., Redgrave, P., and Zheng Y. 2003. The haemodynamic impulse response to a single neural event. J Cereb Blood Flow Metab, Vol 23 no. 5, 546-555.

Berwick, J., Martin, C., Martindale, J., Jones, M., Johnston, D., Zheng, Y., Redgrave, P. and Mayhew, J. 2002. Hemodynamic response in the unanesthetized rat: intrinsic optical imaging and spectroscopy of the barrel cortex. J Cereb Blood Flow Metab 22: 670-9.

Zheng, Y., Martindale, J., Johnston, D., Jones, M., Berwick, J. and Mayhew, J. 2002. A model of the Hemodynamic Response and Oxygen Delivery to Brain. Neuroimage Vol 16, No. 3, 617-37.

Jones, M., Berwick, J. and Mayhew J. 2002. Changes in Blood Flow, Oxygenation and Volume following extended stimulation of Rodent Barrel Cortex. NeuroImage Vol 15, No. 3, 474-484.

Mayhew, J., Johnston, D., Martindale, J., Jones, M., Berwick, J. and Zheng, Y. 2001. Increased oxygen consumption following activation of brain: footnotes using spectroscopic analysis of neural activity in barrel cortex. Neuroimage Vol 13, No. 6, 975-987.

Jones, M., Berwick, J., Johnston, D. and Mayhew, J. 2001. Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation and volume in rodent barrel cortex. NeuroImage Vol 13, No. 6, 1002-1015.

Mayhew, J., Johnston, D., Berwick, J., Jones, M., Coffey, P. and Zheng, Y. 2001. Erratum and Addendum: Spectroscopic Analysis of Neural Activity in Brain: Increased Oxygen Consumption Following Activation of Barrel Cortex. NeuroImage 13, No 3, 540-543.

Mayhew, J., Johnston, D., Berwick, J., Jones, M., Coffey, P. and Zheng, Y. 2000. Spectroscopic analysis of neural activity in brain: increased oxygen consumption following activation of barrel cortex. Neuroimage Vol 12, No. 6, 664-675.

Martindale, J., Berwick, J., Johnston, D., Jones, M., Zheng, Y., Coffey, P., Paley, M. and Mayhew, J. 2000. Pseudo-random procedures for rapid presentation rates using optical imaging and spectroscopy. NeuroReport 10: 2247-2252.

Invited talks: Departmental Seminars

Department of Physiology and Pharmacology, Neuroscience Seminar Series, The University of Bristol, 27/02/12

Faculty of Life Sciences, Neuroscience Research Seminar Series, The University of Manchester, UK. 27/11/10

Department of Life Sciences, The Open University, UK. 10/11/09

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School. USA. 14/01/09.

MRC Centre for Neurodegeneration Research, Institute of Psychiatry, Kings College. London. UK. 04/12/2007.

Teaching Publications and Presentations

Information literacy through inquiry: A Level One psychology module at the University of Sheffield. 2011. McKinney, P., Jones, M. & Turkington, S. Aslib Proceedings, Vol. 63, No. 2/3, 221-240.

Teaching neuroscience to UK psychology undergraduates: An inquiry-based, student-centred approach. K. Smith (Undergraduate Student) & M.Jones (Staff). CILASS staff-student symposium, 13/4/2010.

Teaching Seminar Series, Faculty of Arts & Humanities and Faculty of Social Sciences. University of Reading. 3/3/10. (Invited)

Inquiry-based Learning across the curriculum, HEA/CILASS Workshop: Exploring Inquiry-Based Learning, 15/1/2010.(Invited)

M. Jones and P. McKinney (2008)“Journals contain Facts unlike the Daily Mail”: implementation of an inquiry-based learning task enabling evaluation of information sources. Psychology Learning and Teaching (PLAT) HEA Conference Paper presentation, University of Bath, 02/7/08. (Invited)

M. Jones and P. McKinney (2008)“Journals contain facts unlike the daily mail”: implementation of an inquiry-based learning task enabling evaluation of information sources. LTEA Conference, Paper presentation, University of Sheffield, 6/06/08

'Critical appraisal of the public presentation of psychology': A 3 tiered approach to facilitated inquiry: undergraduate students, associate tutors & staff. Thomas, G. (UG student), Jones, E. (PG associate tutor) & Jones, M. (Staff). CILASS staff-student symposium, 30/4/2007.