Representative Publications

Staples CJ, Myers KN, Beveridge RD, Patil AA, Lee AJ, Swanton C, Howell M, Boulton SJ & Collis SJ.
The centriolar satellite protein Cep131 is important for genome stability.
J Cell Sci. Advance Online Publication July 13, 2012, doi:10.1242/jcs.104059

Camp NJ*, Parry P*, Knight S, Abo R, Elliott G, Rigas S, Balasubramanian SP, Reed MWR, McBurney H, Latif A, Newman WG, Cannon-Albright LA, Evans DG, Cox A.
Fine-mapping CASP8 risk variants in Breast Cancer.
Cancer Epidemiology, Biomarkers and Prevention 2012 21, 176-81

Gagou, M.E., Ganesh, A., Thompson, R., Phear, G., Sanders, C. and Meuth, M. (2011)
The human Pif1 helicase suppresses apoptosis in response to DNA replication inhibitors in tumor cells.
Cancer Res. In press.

Gravells P, Hoh L, Canovas D, Rennie IG, Sisley K, Bryant H. (2011)
Resistance of uveal melanoma to the interstrand cross-linking agent mitomycin C is associated with reduced expression of CYP450R.
Br J Cancer. 2011 Mar 29;104(7):1098-105

Hoh L, Gravells P, Canovas D, Ul-Hassan A, Rennie IG, Bryant H, Sisley K. (2011)
Atypically low spontaneous sister chromatid exchange formation in uveal melanoma.
Genes Chromosomes Cancer. 2011 Jan;50(1):34-42.

Dudziec E et al. (2011)
Hypermethylation of CpG Islands and Shores adjacent to mirtron and microRNA genes in bladder cancer.
Clin Cancer Res. 2011 Jan 28

Lin WY, Camp NJ, Cannon-Albright LA, Allen-Brady K, Balasubramanian S, Reed MW, Hopper JL, Apicella C, Giles GG, Southey MC, Milne RL, Arias-Pérez JI, Menéndez-Rodríguez P, Benítez J, Grundmann M, Dubrowinskaja N, Park-Simon TW, Dörk T, Garcia-Closas M, Figueroa J, Sherman M, Lissowska J, Easton DF, Dunning AM, Rajaraman P, Sigurdson AJ, Doody MM, Linet MS, Pharoah PD, Schmidt MK, Cox A. (2011)
A role for XRCC2 gene polymorphisms in breast cancer risk and survival.
J Med Genet. 2011 Jul;48(7):477-84. Epub 2011 May 31.

Broeks, A et al. (2011)
Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: Findings from the Breast Cancer Association Consortium.
Hum Mol Genet 2011 Jun 9. [Epub ahead of print]

Kote-Kote-Jarai, Z. et al. (2011)
Seven novel prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
Nat Genet in press

Gagou, M.E., Zuazua-Villar, P. and Meuth, M. (2010)
Enhanced H2AX phosphorylation, DNA replication fork arrest and cell death in the absence of Chk1.
Mol. Biol. Cell, 21, 739-752.

Meuth, M. (2010)
Chk1 suppressed cell death (review).
Cell Division 5:21doi:10.1186/1747-1028-5-21

Chu MLH, Lang Z, Chavas LMG, Neres J, Federova OS, Tabernero L, Cherry M, Williams DH, Douglas KT and Eyers PA. (2010)
Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes
Biochemistry (2010) 49: 1689-1701

Chu MLH and Eyers PA. (2010)
UCSD/Nature Signaling Gateway, Molecule Pages: Mps1


Sloane DA Trikic MZ, Lang Z, Chu MLH, Lamers MBAC, Mason CS, Mueller I, Savory WJ, Williams DH and Eyers PA. (2010)
Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237
ACS Chem. Biol. (2010) 5: 563-576.

Sanders C. (2010)
Human Pif1 helicase is a G-quadruplex DNA binding protein with G-quadruplex DNA unwinding activity.
Biochem. J. 430, 119-128.

Azzato, EM et al (2010)
Association Between a Germline OCA2 Polymorphism at chromosome 15q13.1 and estrogen receptor–Negative Breast cancer Survival
JNCI published online March 2010 doi:10.1093/jnci/djq057

Murad AS, Davey Smith G, Lewis SJ, Cox A, Donovan JL, Neal DE, Hamdy FC, Martin RM. (2010)
A polymorphism in the glucokinase gene that raises plasma fasting glucose, rs1799884, is associated with diabetes mellitus and prostate cancer: findings from a population-based, case-control study (the ProtecT study).
Int J Molecular Epidemiology and Genetics 2010. In press.

Blows, F. et al (2010)
Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies.
PLoS Medicine In press

Adamo A*, Collis SJ*, Adelman CA, Silva N, Ward JD, Martinez-Perez E, Boulton SJ & La Volpe A. (2010)
*co-first authorship
Preventing Non-Homologous End Joining Suppresses DNA repair defects of Fanconi Anemia.
Molecular Cell 39(1), 25-35 2010.

Owen HC, et al. (2010)
Low frequency of epigenetic events in urothelial tumors from young patients.
J Urol. 2010 Aug;184(2):459-63

Catto JWF, et al. (2010)
Microarray analysis using artificial intelligence identifies a novel progression signature for superficial bladder cancer.
Eur Urol 2010 Mar;57(3):398-406

Blundred R, Myers K, Helleday T, Goldman AS, Bryant HE. (2010)
Human RECQL5 overcomes thymidine-induced replication stress.
DNA Repair (Amst). 2010 Sep 4;9(9):964-75.

Gottipati P, Vischioni B, Schultz N, Solomons J, Bryant HE, Djureinovic T, Issaeva N, Sleeth K, Sharma RA, Helleday T. (2010)
Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells.
Cancer Res. 2010 Jul 1;70(13):5389-98.

Loseva O, Jemth AS, Bryant HE, Schüler H, Lehtiö L, Karlberg T, Helleday T. (2010)
PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.
J Biol Chem. 2010 Mar 12;285(11):8054-60.