Dr Peter Grabowski BSc, MSc, PhD
Department of Oncology
Academic Unit of Human Nutrition
E Floor, The Medical School
Beech Hill Road
Sheffield
S10 2RX
UK
Office: EU29
Tel: +44 (0)114 271 3782
Fax: +44 (0)114 271 3314
email: p.grabowski@sheffield.ac.uk
Biography
I studied Pharmacology at the University of Liverpool and was awarded my PhD in 1987. I undertook postdoctoral work in drug metabolism in liver disease with Prof. Edgar Ohnhaus at the Christian Albrechts Universität in Kiel, Germany, and on thyroid autoantibody repertoires with Prof. Richard Himsworth in Aberdeen. I developed an interest in bone and joint biology working with Prof. Stuart Ralston in Aberdeen and Prof. Tim Skerry in York. I joined the University of Sheffield in 1999 when I was appointed Lecturer in Bone Biology in the Academic Unit of Child Health under Prof. Nick Bishop. I joined the Academic Unit of Human Nutrition in 2012 to support the MMedSci course.
Research Interests
My research interests lie in the biology and pathology of bones and joints. I have broad interest in molecular and cellular signalling mechanisms in bone and joint cells and in the impact of genetic, lifestyle (including nutrition) and environmental factors on bone and joint health and disease throughout life.
Teaching Interests
I am deputy lead for the MMedSci/Postgraduate Diploma in Human Nutrition. I am a Pathway and Module leader on the Experimental Medicine Pathway for the M.Sc. in Molecular Medicine. Outside of the University, I am a faculty member on the Advanced Course in Calcium Metabolism for the British Paediatric and Adolescent Bone Group of the Royal College of Paediatrics and Child Health.
Professional Activities
I am a member of the European Calcified Tissue Society, the International Bone and Mineral Society, the Bone Research Group the British Society for Research into Ageing and the Nutrition Society. I am an Affiliate Member of the Royal College of Paediatrics and Child Health and a member of the College´s British Paediatric and Adolescent Bone Group. I am a member of the Scientific Advisory Committee for Sheffield Children´s Hospital Charity.
Current Projects
The role of acid sensing proteins in rheumatoid arthritis
Glucagon like peptide 2 and feeding: effects on bone turnover
Microindentation analysis of bone quality
Key Publications
Little R, Muimo R, Robson L, Harris K, Grabowski PS. The transient receptor potential ion channel TRPV6 is expressed at low levels in osteoblasts and has little role in osteoblast calcium uptake. PLoS One 2011 6:e28166.
Grabowski P. Physiology of bone. Endocr Dev 2009 16:32-48.
Sobacchi C, Frattini A, Guerrini MM, Abinun M, Pangrazio A, Susani L, Bredius R, Mancini G, Cant A, Bishop N, Grabowski P, Del Fattore A, Messina C, Errigo G, Coxon FP, Scott DI, Teti A, Rogers MJ, Vezzoni P, Villa A, Helfrich MH. Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL. Nat Genet 2007 39:960-2.
Holmes SG, Still K, Buttle DJ, Bishop NJ, Grabowski PS Chemically modified tetracyclines act through multiple mechanisms directly on osteoclast precursors. Bone 2004 35:471-8.
Peet NM, Grabowski PS, Laketic-Ljubojevic I, Skerry TM. The glutamate receptor antagonist MK801 modulates bone resorption in vitro by a mechanism predominantly involving osteoclast differentiation. FASEB J 1999 13:2179-85.
Grabowski PS, Wright PK, Van 't Hof RJ, Helfrich MH, Ohshima H, Ralston SH. Immunolocalization of inducible nitric oxide synthase in synovium and cartilage in rheumatoid arthritis and osteoarthritis. Br J Rheumatol 1997 36:651-5.
Ralston SH, Grabowski PS Mechanisms of cytokine induced bone resorption: role of nitric oxide, cyclic guanosine monophosphate, and prostaglandins. Bone 1996 19:29-33.
Grabowski PS, England AJ, Dykhuizen R, Copland M, Benjamin N, Reid DM, Ralston SH. Elevated nitric oxide production in rheumatoid arthritis. Detection using the fasting urinary nitrate:creatinine ratio. Arthritis Rheum 1996. 39(4):643-7
Grabowski PS, Macpherson H, Ralston SH. Nitric oxide production in cells derived from the human joint. Br J Rheumatol 1996 35:207-12.
Grabowski PS, Park BK. Drug-protein conjugates--VII. Disposition of [3H]-ethinylestradiol-protein conjugates in the rat. Biochem Pharmacol 1984 15;33:3289-94.