Dr. Jon Wood PhD
Academic Neurology Unit
Department of Neuroscience
Sheffield Institute of Translational Neuroscience
University of Sheffield
Room B28
385a Glossop Road
Sheffield
S10 2HQ
Telephone: +44 (0)114 22 22243
Fax: +44 (0)114 22 22290
E-mail: J.D.Wood1@sheffield.ac.uk
Secretary: Rebecca Brown
Tel: 0114 22 22261
Email:rebecca.brown@sheffield.ac.uk
Biography:
I joined the department in 2001 after postdoctoral work on Huntington disease and other polyglutamine disorders at the University of Wales College of Medicine in Cardiff (1994-96) and the Laboratory of Molecular Neurobiology at the Johns Hopkins Medical Institutions in Baltimore (1996-2001).
Research Interests:
My research is focussed on molecular mechanisms underlying neurodegenerative disorders and neurodevelopmental pathways that confer susceptibility to neuropsychiatric diseases such as schizophrenia. Much of this work is carried out in collaboration with colleagues in the MRC Centre for Developmental and Biomedical Genetics
Teaching Activities:
I organise and deliver teaching within modules on the Neuroscience Pathway of the the MSc in Molecular Medicine. I have also been heavily involved in the development of a new Masters programme in Translational Neuroscience .
Key Publications
Butler, R., Wood, J.D., Landers, J.A. & Cunliffe, V.T. (2010). Genetic and chemical modulation of Spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in Hereditary Spastic Paraplegia. Disease Models and Mechanisms Abstract
Wood, J.D., Bonath, F., Kumar, S., Ross, C.A. & Cunliffe, V.T. (2009). Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain. Human Molecular Genetics 18, 391-404. Abstract
Sato, T., Miura, M., Yamada, M., Yoshida, T., Wood, J.D., Yazawa, I., Masuda, M., Suzuki, T., Shin, R.-M., Yau, H.-J., Liu, F.-C., Shimohata, T., Igarashi, S., Onodera, O., Ross, C.A., Katsuki, M., Takahashi, H., Kano, M., Aosaki, T. & Tsuji, S. (2009). Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice. Human Molecular Genetics 18, 723-736. Abstract
Kasher, P.R., De Vos, K.J., Wharton, S.B., Manser, C., Bennett, E.J., Bingley, M., Wood, J.D., Milner, R., McDermott, C.J., Miller, C.C.J., Shaw, P.J. & Grierson, A.J. (2009). Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients. Journal of Neurochemistry 110, 34-44 Abstract
Wood, J.D., Landers, J.A., Bingley, M., McDermott, C.J., Thomas-McArthur, V.T., Gleadall, L.J., Shaw, P.J. & Cunliffe, V.T. (2006). The microtubule-severing protein spastin is required for motor axon outgrowth in the zebrafish embryo. Human Molecular Genetics 15, 2763-2771. Abstract.