The University of Sheffield
The Medical School

Dr. Stephen B Wharton MRCPath

Senior clinical lecturer and Honorary consultant in Neuropathology

Dr Stephen Wharton

Department of Neuroscience
Sheffield Institute of Translational Neuroscience
University of Sheffield
Room B34
385a Glossop Road
Sheffield
S10 2HQ
Fax: +44 (0)114 22 22235
Email: s.wharton@sheffield.ac.uk

Secretary: Rebecca Brown
Tel: +44 (0)114 22 22261
Email:rebecca.brown@sheffield.ac.uk

Career History


Qualifications


Research

Current interests lie in the clinical and molecular pathology of brain ageing and neurodegenerative diseases. Major areas:

Pathology of cognitive impairment – through involvement with the MRC Cognitive Function and Ageing Study, in collaboration with Professor Ince. This study takes a population-based approach to the neuropathology of dementia. Areas of interest within this: 1. role of glial pathology in brain ageing and development of Alzheimer-type pathology, 2. tau pathology, 3. pathology of age-related white matter lesions.

Motor system pathology and tissue banking in collaboration with Prof Ince and Prof Shaw.

Diagnostic interests in neuro-oncology related to clinical practice in this area.


External Professional Activities


Membership of Associations and Societies


Representative Publications (last 5 years)

Simpson JE, Ince PG, Higham CE, Gelsthorpe CH, Fernando MS, Matthews F, Forster G, O´Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Stoeber K, Williams GH, Lewis, CE, Wharton SB, on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group. Microglial activation in white matter lesions and nonlesional white matter of ageing brains. Neuropathol Appl Neurobiol 2007; 33:670-683.

Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, O´Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Lewis CE, Wharton SB, MRC-CFAS. White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses. Neuropathol Appl Neurobiol 2007; 33:410-419.

Wharton SB, Maltby E, Jellinek DA, Levy D, Atkey N, Hibberd S, Crimmins D, Stoeber K, Williams GH. Subtypes of oligodendroglioma defined by 1p, 19q deletions, differ in the proportion of apoptotic cells but not in replication-licensed non-proliferating cells. Acta Neuropathol 2007; 113:119-127.

Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB, Shaw PJ, O´Brien JT, Ince PG, on behalf of MRC-CFANS. White matter lesions in an unselected cohort of the elderly. Molecular pathology suggests origin from chronic hypoperfusion injury. Stroke 2006;37:1391-1398.(Subject of an editorial; Stroke 2006; 37:1348-8).

Brockington A, Wharton SB, Fernando M, Gelsthorpe CH, Baxter L, Ince PG, Lewis CE, Shaw PJ. Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 2006; 65:26-36.

Baron P, Bussini S, Cardin V, Corbo M, Conti G, Galimberti D, Scarpini E, Bresolin N, Wharton SB, Shaw PJ, Silani V. Production of monocyte chemoattractant protein-1 in amyotrophic lateral sclerosis. Muscle Nerve 2005; 32:541-544.

Wharton SB, Williams GH, Stoeber K, Gelsthorpe CH, Baxter L, Johnson AL, Ince PG, MRC-CFAS. Expression of Ki67, PCNA and the chromosome replication licensing protein Mcm2 in glial cells of the ageing human hippocampus increases with the burden of Alzheimer-type pathology. Neurosci Letts 2005; 383:33-38.

Henson JD, Hannay JA, McCarthy SW, Royds JA, Yeager TR, Robinson RA, Wharton SB, Jellinek DA, Arbuckle SM, Yoo J, Robinson BG, Learoyd DL, Stalley PD, Bonar SF, Yu D, Pollock RE, Reddel RR. A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas. Clin Cancer Res 2005; 11:217-225.

Bell HS, Whittle IR, Bader SA, Wharton SB. Discovery of a perinecrotic 60 kDa MDM2 isoform within glioma spheroids and glioblastoma biopsy material. Neuropathol Appl Neurobiol 2005; 31:191-202.

Wharton SB, Hibberd S, Eward KL, Crimmins D, Jellinek DA, Levy D, Stoeber K, Williams GH. DNA replication licensing and cell cycle kinetics of oligodendroglial tumours. Br J Cancer 2004; 91:262-269.

Wharton SB, McDermott CJ, Grierson AJ, Wood JD, Gelsthorpe C, Ince PG, Shaw PJ. The cellular and molecular pathology of the motor system in hereditary spastic paraparesis due to mutation of the spastin gene. J Neuropathol Exp Neurol 2003; 62:1166-1177.

McDermott CJ, Grierson AJ, Wood JD, Bingley M, Wharton SB, Bushby KMD, Shaw PJ. Hereditary spastic paraparesis: disrupted intracellular transport associated with spastin mutation. Ann Neurol 2003; 54:748-759.

Ince PG, Evans J, Knopp M, Forster G, Hamdalla HHM, Wharton SB, Shaw PJ. Corticospinal tract degeneration in the progressive muscular atrophy variant of ALS. Neurology 2003; 60:1252-1258.

Miller MW, Peter A, Wharton SB, Wyllie AH. Proliferation and death of conditionally immortalized neural cells from murine neocortex: p53 alters the ability of neuron-like cells to re-enter the cell cycle. Brain Res 2003; 965:57-66.

Allen S, Heath PR, Kirby J, Wharton SB, Cookson MR, Menzies FM, Banks RE, Shaw PJ. Analysis of the cytosolic proteome in a cell-culture model of familial amyotrophic lateral sclerosis reveals alterations to the proteasome, antioxidant defences and nitric oxide synthetic pathways. J Biol Chem 2003; 278:6371-6383.