The University of Sheffield
The Medical School

Professor Anthony Weetman MD DSc FRCP FMedSci

Professor Tony Weetman

Pro Vice Chancellor, Faculty of Medicine, Dentistry and Health
Sir Arthur Hall Professor of Medicine

Faculty of Medicine, Dentistry and Health
University of Sheffield
Beech Hill Road
Sheffield
S10 2RX

Telephone: 44 (0)114 271 2357
Fax: 44 (0)114 271 3960
Email: a.p.weetman@sheffield.ac.uk

Secretary: Ms Bex Clark
Telephone: 44 (0)114 271 2570
Email: Rebecca.clark@sheffield.ac.uk


Career History


Research

Research into the pathogenesis of autoimmune endocrine disease, especially thyroid disease. Current projects include the immunogenetics of Graves´ disease, the molecular characterisation of thyroid and parathyroid autoantibodies and work on autoantigen identification in vitiligo, a skin disorder found in increased frequency in Graves´ disease


Principal Funding Sources


Members of Research Group


Representative Publications (last 5 years)

BLOMHOFF A., LIE B.A., MYHRE A.G., KEMP E.H., WEETMAN A.P., AKSELSEN H.E., HUSEBY E.S., UNDLIEN D.E. Polymorphisms in the cytotoxic T lymphocyte antigen-4 gene region confer susceptibility to Addison´s disease. J.Clin.Endocrinol.Metab. 2004 89: 3474-3476.

CHEN F., DAY SL., METCALFE RA., SETHI G., KAPEMBWA MS., BROOK MG., CHURCHILL D, de RUITER A., ROBINSON S., LACEY CJ., WEETMAN AP. Characteristics of autoimmune thyroid disease occurring as a late complication of immune reconstitution in patients with advanced human immunodeficiency virus (HIV) disease. Medicine (Baltimore). 2005 84:98-106.

DECHAIRO B.M., ZABANEH D., COLLINS J., BRAND O., DAWSON GJ., GREEN A.P., MACKAY I., FRANKLYN J.A., CONNELL J.M., WASS J.A., WIERSINGA W.M., HEGEDUS L., BRIX T., ROBINSON B.G., WEETMAN A.P., CAREY A.H., GOUGH S.C. Association of the TSHR gene with Graves´ disease: the first disease specific locus. Eur J Hum Genet. 2005 13: 1223-1230.

WEETMAN A.P. Graves´ hyperthyroidism: how long should antithyroid drug treatment be continued to achieve remission? Nature Clinical Practice Endocrinol & Metab. 2006 2: 2-3

GOTTUMUKKALA R.V.S.R.K., GAVALAS N.G., AKHTAR S., METCALFE R.A, GAWKRODGER D.J., HAYCOCK J.W., WATSON P.F., WEETMAN A.P., KEMP E.H. Function blocking autoantibodies to the melanin-concentrating hormone receptor in vitiligo patients. Lab Invest 2006 86: 781-789.

TAYLOR J.C., GOUGH S.C., HUNT P.J., BRIX T.H., CHATTERJEE K., CONNELL J.M., FRANKLYN J.A., HEGEDUS L., ROBINSON B.G., WIERSINGA W.M., WASS J.A.H., ZABANEH D., MACKAY I., WEETMAN A.P.A genome-wide screen in 1119 relative pairs with autoimmune thyroid disease. J Clin Endocrinol Metab 2006 91: 646-653.
GAVALAS N.G., AKHTAR S., GAWKRODGER D.J., WATSON P.F., WEETMAN A.P., KEMP E.H. Analysis of allelic variants in the catalase gene in patients with the skin depigmenting disorder vitiligo. Biochem Biophys Res Com 2006 345:1586-1591.

GAVALAS N.G., KEMP E.H., KROHN K.J.E., BROWN E.M., WATSON P.F., WEETMAN A.P The calcium–sensing receptor is a target of autoantibodies in patients with autoimmune polyendocrine syndrome type 1. J.Clin.Endocrinol.Metab. 2007 92: 2107-2714

JAMESON, J.L., WEETMAN, A.P. Disorders of the thyroid gland. In: Harrison´s Principles of Internal Medicine. Eds. Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., Jameson, J.L. 17th Edition, 2008 pp2224 – 224

AJJAN R.A., WEETMAN A.P. Techniques to quantify TSH receptor antibodies.
Nature Clinical Practice Endocrinol & Metab. 2008 4: 461-468

BRAND O., BARRETT J.C., SIMMONDS M.J., NEWBY P.R., McCABE C.J., BRUCE C.K., KYSELA B., CARR-SMITH J.D., BRIX T., HUNT P.J., WIERSINGA W.M., HEGEDUS L., CONNELL J.M., WASS J.A.H., FRANKLYN J.A., ROBINSON B.G., WEETMAN A.P., GOUGH S.C.L. Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves´ disease. Human Mol. Gen. 2009 18: 1704- 1713