Dr Kevin Walters BSc MSc PhD
Lecturer
Mathematical Modelling and Genetic Epidemiology
University of Sheffield Medical School
Beech Hill Road
Sheffield
S10 2RX
Telephone: 44 (0)114 271 1648
Fax: 44 (0)114 271 1711
Email: k.walters@sheffield.ac.uk
Secretary: Lesley Keers
Telelephone: 44 (0)114 271 2286
Email: l.keers@sheffield.ac.uk
Career History
2002 – 2004 Research Fellow – University of Leeds
2004 – present Lecturer – University of Sheffield
Research
My modelling research focuses on developing stochastic models in order to better understand molecular processes. Recent work relates to modelling stem cell turnover in the colon.
Recent Publications
Walters, K. 'Colonic stem cell data is consistent with the immortal model of stem cell division under non-random strand segregation.' Cell Prolif. (In press)
Walters, K. 'Modelling diversity in colon crypts for the immortal model of stem cell turnover'. Proceedings of the International Workshop on Applied Probability, 2008. (In press)
Vasilopoulos, Y*., Walters, K.*, Cork, M. J., Duff, G. W., Sagoo, G. S., Tazi-Ahnini, R. 'Association analysis of the skin barrier gene cystatin A at the PSORS5 locus in psoriatic patients: evidence for interaction between PSORS1 and PSORS5' Eur. J. Hum. Genet. (2008) doi: 10.1038/ejhg.2008.40 *Equal contributions.
Marinou, I., Healy, J., Mewar, D., Moore, D. J., Dickson M. C., Binks, M. H., Montgomery D. S., Walters, K., Wilson, A. G. 'Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status' Arthritis Rheum. (in Press)
Walters, K. 'Modelling the probability distribution of the number of DNA double-strand breaks due to sporadic alkylation of nucleotide bases' J. Theor. Biol. (2007) 245: 161 – 168.
Messroghli, D. R., Plein, S., Higgins, D. M., Walters, K., Jones, T., Ridgway, J. P., Sivananthan, M. U. 'Single Breath-Hold T1 Mapping of Human Myocardium with High Spatial Resolution: A Reproducibility Study'. Radiology. (2006) 238: 1004 – 12.
Walters, K. & Cannings, C. 'The probability density of the total IBD length over a single autosome in unilineal relationships' Theor. Popul. Biol. (2005) 68: 55 – 63.
Walters, K. 'The effect of genotyping error in sib-pair genomewide linkage scans depends crucially upon the method of analysis' J. Hum. Genet. (2005) 50: 329 – 37.
Lundin, C., North, M., Erixon, K., Walters, K., Jenssen, D., Goldman, A. S. H., Helleday, T. 'Methyl methanesulfonate (MMS) produces heat-liabile DNA damage but no detectable in vivo DNA double-strand breaks' Nucleic Acids res. (2005) 33: 3799 – 811.
Samani NJ, Burton P, Mangino M, Ball SG, Balmforth AJ, Barrett J, Bishop T, Hall A, Samani NJ, Stribling J, de Souza P, Singh R, Ogleby J, Ridge C, Logtens E, Hopwood L, Faulkes J, Hall AS, Morrell C, Jackson BM, Barthorpe L, Burtonwood N, Dorsch M, Durham N, Forest C, Kelly N, Hall V, Lawrance R, Oldham J, Rennie E, Smith A, Thompson S, Balmforth AJ, Mangino M, Adams S, Braund P, Clemitson JR, Bodycote C, Koekemoer A, Raleigh S, Maqbool A, Yuldasheva N, Ellis S, Mason S, Midgley L, Pleasants N, Cuthbert R, Tooze PF, Braund P, Mangino M, Platts M, Fox J, Dixon R, Barrett J, Burton P, Mangino M, Sheehan N, Scurrah K, Bishop T, Pickett S, Walters K, Nsengimana J, Hall AS, Samani NJ, Balmforth AJ, Burton P, Bishop T, Ball SG. 'A genome-wide linkage study of 1933 families affected by premature coronary artery disease: The British Heart Foundation Family Heart Study' Am. J. Hum. Genet. (2005) 77: 1011 – 1020.
Alfakih, K., Maqbool, A., Sivananthan, M., Walters, K., Bainbridge, G., Ridgway, J., Balmforth, A. J., Hall, A.S. 'Left ventricle mass index and the common, functional, X- linked angiotensin II type 2-receptor gene polymorphism (–1332 G/A) in patients with systemic hypertension' Hypertension (2004) 43: 1189 – 1194.
Alfakih, K., Walters, K., Jones, T., Ridgway, J., Hall, A. S., Sivananthan, M. 'New gender-specific partition values for ECG criteria of left ventricular hypertrophy - Recalibration against cardiac MRI' Hypertension (2004) 44: 175 – 179.
Iles, M. M., Walters, K. & Cannings, C. 'Recombination can evolve in large finite populations given selection on sufficient loci' Genetics (2003) 165: 2249 – 2258.
Walters, K. & Blackwell, P. G. 'Group Formation Games with Reappraisal,' J. Theor. Biol. (2002) 217: 149 – 157.