Dr. Jonathan P. Bury MB ChB BMedSci MPhil FRCPath
Honorary Senior Lecturer, Consultant Histopathologist
Academic Unit of Pathology
Department of Neuroscience
University of Sheffield Medical School
Beech Hill Road
Sheffield
S10 2RX
UK
Telephone: +44 (0)114 271 4849
Email: j.p.bury@sheffield.ac.uk
Biography
I graduated from Sheffield Medical School in 1996, having intercalated a BMedSci in Pathology on the role of image analysis in the cytological diagnosis of breast cancer. After clinical posts, I spent two years as a Clinical Research Fund in what was then the Imperial Cancer Research Fund, now Cancer Research UK.
I returned to Sheffield in 2002 to combine specialist training in Diagnostic Histopathology with a Clinical Lectureship in Pathology. During this time I established a research group focussing on the pathogenesis of oesophageal cancer, with external funding from Yorkshire Cancer Research and Bardhan Research and Educational Trust of Rotherham. I am currently a Consultant Histopathologist at the Northern General Hospital, Sheffield, specialising in Gastrointestinal and Lung pathology, and Honorary Senior Lecturer at the University of Sheffield.
Research Interests
My primary area of interest is in the biology of metaplasia, particularly where this intersects with my clinical interest in gastrointestinal pathology. With Professor Sheila MacNeil, I´ve developed a novel 3-D tissue engineered model of the human oesophageal mucosa which provides an unparalleled platform for investigating the role of insults such as gastroduodenal refluxate in the development of Barrett´s metaplasia and oesophageal adenocarcinoma. I also collaborate with Dr Bernard Corfe and colleagues in the Human Nutrition Unit, on studies focussing dietary influences on colonic crypt cell population dynamics, as well as Dr Angie Cox and Dr Carolyn Station.
Teaching Interests
I lecture on the following courses: BMedSci Orthoptics, MSc Nutritional Sciences, MSc Pathological Sciences, and MB ChB. I authored the chapter "Disorders of growth, differentiation and morphogenesis" in the 5th edition of "General and Systematic Pathology" (Eds Cross SS and Underwood JCE), and will additionally be co-authoring the chapter "Response to cellular injury" in the forthcoming 6th edition.
Professional Activities
- Fellow of the Royal College of Pathologists
- Member, Pathological Society of Great Britain and Ireland
- Member, British Society for Clinical Cytology
- Member. British Division of the International Academy of Pathology
Current Projects
- Integrative modelling of the Pathogenesis of Barrett’s Metaplasia (with Professor Sheila MacNeil and Dr Nicola Green)
- The role of butyrate in colonic carcinogenesis and regulation of entgeroendocrine cell numbers (with Dr Bernard Corfe)
Key publications [not a full list, just key outputs]
Nakano E, Mushtaq S, Heath PR, Lee ES, Bury JP, Riley SA, Powers HJ, Corfe BM. Riboflavin Depletion Impairs Cell Proliferation in Adult Human Duodenum: Identification of Potential Effectors. Dig Dis Sci. 2010 Sep 17. DOI: 10.1007/s10620-010-1374-3
Green N, Huang Q, Khan L, Battaglia G, Corfe B, MacNeil S, ,b>Bury JP. The Development and Characterisation of a Tissue Engineered Human Oesophageal Mucosal Model. Tissue Eng Part A. 2010 Mar;16(3):1053-64.
Corfe BM, Williams EA, Bury JP, Riley SA, Croucher LJ, Lai DY, Evans CA. A study protocol to investigate the relationship between dietary fibre intake and fermentation, colon cell turnover, global protein acetylation and early carcinogenesis: The FACT Study (ISRCTN90852168). BMC Cancer Sept 2009 Sep 18;9:332
Allan JM, Shorto J, Adlard J, Bury J, Coggins R, George R, Katory M, Quirke P, Richman S, Scott D, Scott K, Seymour M, Travis LB, Worrillow LJ, Bishop DT, Cox A; UK NCRI Colorectal Clinical Studies Group; Colorectal Cancer Study Group. MLH1 -93G>A promoter polymorphism and risk of mismatch repair deficient colorectal cancer. Int J Cancer. 2008 Nov 15;123(10):2456-9.
Croucher LJ, Bury JP, Williams EA, Riley SA, Corfe BMC. Commonly used bowel preparations have significant and different effects upon cell proliferation in the colon: a pilot study. BMC Gastroenterology; 2008 Nov 14;8(1):54
Boult J, Roberts K, Brookes MJ, Hughes S, Bury JP, Cross SS, Anderson GJ, Spychal R, Iqbal T, Tselepis C. Overexpression of cellular iron import proteins is associated with malignant progression of esophageal adenocarcinoma. Clin Cancer Res. 2008 Jan 15;14(2):379-87.
Bury J, Hurt C, Roy A, Cheesman L, Bradburn M, Cross S, Fox J, Saha V. LISA: a web-based decision-support system for trial management of childhood acute lymphoblastic leukaemia. Br J Haematol. 2005 Jun;129(6):746-54.
Peleg M, Tu S, Bury J, Ciccarese P, Fox J, Greenes RA, Hall R, Johnson PD, Jones N, Kumar A, Miksch S, Quaglini S, Seyfang A, Shortliffe EH, Stefanelli M. "Comparing Computer-interpretable Guideline Models: A Case-study Approach". J Am Med Inform Assoc 2003; 10(1), 52-68.
Cross SS, Bury JP, Stephenson TJ, Harrison RF. "Image analysis of low magnification images of fine needle aspirates of the breast produces useful discrimination between benign and malignant cases". Cytopathology 1997; 8(4), 265-73.