The University of Sheffield
Department of Infection and Immunity

Professor Ian Sabroe MBBS BSc AKC PhD FRCP

Professor of Inflammation Biology
Co-Director, Medical Humanities Sheffield

ORCID reference

Ian Sabroe

Academic Unit of Respiratory Medicine
Department of Infection and Immunity
The Medical School
Beech Hill Road
Sheffield
S10 2RX
UK

Tel: +44 (0)114 271 3243
Email: i.sabroe@sheffield.ac.uk
Secretary:  Jean Lazenby
Tel:  +44 (0)114 271 2237
Email:  j.lazenby@sheffield.ac.uk
Fax:  +44 (0)114 271 3892

Biography

I am a respiratory physician with clinical interests in severe asthma and in pulmonary hypertension, and research interests in mechanisms of airway and vascular inflammation. My group is looking for new ways of understanding and treating human lung disease, particularly where it involves inflammation.

I undertook most of my clinical training in London, with respiratory training particularly at the Hammersmith Hospital, the Royal Brompton Hospital, and Imperial College London, in Prof Tim Williams's lab, coupled with a brief research elective with Prof Craig Gerard (Harvard).

I moved to Sheffield in 2000 on an MRC Clinician Scientist Fellowship, and subsequently an MRC Senior Clinical Fellowship, to study how TLR-driven inflammation contributes to airways disease. I established the severe asthma clinical service, and now actively participate in the delivery of care to patients with pulmonary arterial hypertension.

Research Interests

I am involved in developing interdisciplinary research in the field of medical humanities, and co-direct the Sheffield Centre (links adjacent).  Medical Humanities Sheffield has an extensive portfolio of research and teaching covering broad fields from history to literature to the law, and their links with biomedical science and medicine.

My group has numerous interests within respiratory medicine, particularly focusing on airway and vascular inflammation, and the biology of the innate immune system. We study the roles of TLRs in airway and vascular inflammation, using TLR agonists and natural viral pathogens. We are interested in how diesel nanoparticulate pollution exacerbates airways disease. We are also interested in how airways inflammation is initiated, why people with lung disease are at greater risk of coronary vascular disease, and whether inflammation contributes to the biology of pulmonary arterial hypertension. We are developing new treatments for human TLR-induced inflammation, and setting up new models of inflammation in human volunteers to probe how inflammation might work and best be treated.

My work is funded by the Medical Research Council, the Wellcome Trust, Asthma UK, Heart Research UK, and the NIHR.  We are very grateful for all the support we receive.

Professional Activities

I am subspeciality lead for Asthma in the Sheffield Thoracic Institute.
I chair the Scientific Advisory Board of the Clinical Research Facility.
I serve on an MRC Funding Board.
I have established and lead a popular education meeting, focusing on managing difficult lung disease in the real world, using case-based teaching. The 2012 meeting will focus on PH, infection, cancer and asthma.

Publications

My publications (comprising to date >95 articles in translational research and clinical medicine) can be seen at my ORCID site: http://orcid.org/0000-0001-9750-8975