Dr Lynne Prince MSc PhD

Department of Infection and Immunity
L Floor
The University of Sheffield Medical School
Beech Hill Road
Sheffield
S10 2RX
UK

Tel: +44 (0)114 271 3452
Fax: +44 (0)114 226 8898
Email: l.r.prince@sheffield.ac.uk

Biography

I graduated from Newcastle University in 1997 with a degree in medical microbiology. I then studied for the MSc in pathological sciences at the University of Sheffield (1999) which led to my PhD entitled `The regulation of neutrophil apoptosis by bacterial products´ (2003). In 2004 I was awarded a University of Sheffield Russell Research Fellowship to study the molecular mechanisms of neutrophil activation and apoptosis.

Research Interests

Inflammation and inflammatory diseases such as chronic obstructive pulmonary disease, or rheumatoid arthritis are extremely difficult to treat effectively. During inflammation, inflammatory cells, in particular neutrophils and monocytes, are thought to be key mediators of both tissue damage and perpetuation of further inflammatory signalling. My research focuses on the role of neutrophils in inflammation and how their inflammatory potential is regulated by apoptosis.

Professional activities

• I am a member of the society of Leukocyte Biology.

Current projects

• 2010-2013 MRC PhD studentship “The role of Hax1 in regulating myeloid cell survival in vitro and in vivo” (Dr Lynne Prince, Dr Steve Renshaw).
• 2008-2011 MRC PhD studentship “The regulation of TIR signalling via Pellinos” (Prof Ian Sabroe, Prof Moira Whyte, Dr Lynne Prince).
• 2010-2011 BMedSci studentship “The use of a genome wide drosophila screen to identify regulators of inflammatory signalling”.
• 2009-2010 BMedSci studentship “Using a differentiated myeloid cell line to dissect phagocytosis of environmental particles".

Key publications

1. S. Anwar, L.R.Prince, S. J. Foster, M. K. B. Whyte and I. Sabroe. The rise and rise of Staphylococcus aureus: laughing in the face of granulocytes. Clin Exp Immunol, 2009, 157:216-224.
   
   
2. E. P. Dick, L.R Prince, E. Jones, S. A. Renshaw, M. K. B. Whyte, and I Sabroe. Pathways regulating LPS-induced Neutrophil Survival Revealed by Lentiviral Transduction of Primary Human Neutrophils. Immunology, 2008, , 127:249-255.
   
   
3. E. P. Dick, L.R.Prince and I. Sabroe. Ex Vivo Expanded BM CD34+ Derived Neutrophils Have Limited Bactericidal Ability. Stem Cells, 2008, 26:2552-2563.
   
   
4. L. R. Prince, S. M. Bianchi, K. Vaughan, M. B. Bewley, H. M. Marriott, S. R. Walmsley, G. W. Taylor, D. J. Buttle, I. Sabroe, D. H. Dockrell and M. K. B. Whyte. Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin. J Immunol, 2008, 180(5):3502-11.
   
   
5. S. M. Bianchi, L. R. Prince, K. McPhillips, L. Allen, H. M. Marriott, G. W. Taylor, P. G. Hellewell, I. Sabroe, D. H. Dockrell, P. W. Henson and M. K. B. Whyte. Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa. Am J Respir Crit Care Med, 2008, 177(1):35-43.
   
   
6. K. Vaughan, L. Stokes, L. R. Prince, S. Meis, M. U. Kassak, C. D. Bingle, I. Sabroe, A. Surprenant and M. K. B. Whyte. Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor. J Immunol, 2007, 179(12):8544-53.
   
   
7. L. C. Parker, L. R. Prince and I. Sabroe. Networks regulated by Toll-like receptors mediate innate and adaptive immunity. Review. Clin Exp Immunol, 2007, 147(2): 199-207.
   
   
8. L. Parker, E. C. Jones, L. R. Prince, S. K. Dower, M. K. B. Whyte and I. Sabroe. Endotoxin Tolerance Induces Selective Alterations in Neutrophil Function. J Leukoc Biol, 2005, 78: 1301-1305.
   
   
9. L. R. Prince, L. Allen, P. G Hellewell, S. K. Dower, M. K. B. Whyte and I. Sabroe. The Role of IL-1b in Toll-like Receptor 4-mediated Neutrophil Activation and Survival. Am J Pathol, 2004, 165:1819-1826.
   
   
10. I. Sabroe, L. R. Prince, S. K. Dower, S. R. Walmsley, E. R. Chilvers and M. K. B. Whyte. What Can We Learn From Highly Purified Neutrophils? Biochem Soc Trans, 2004, 32:468-469.
    
    
11. D. H. Dockrell, H. M. Marriott, L. R. Prince, V. C. Ridger, P. G. Ince, P. G. Hellewell and M. K. B. Whyte. Alveolar Macrophage Apoptosis Contributes to Pneumococcal Clearance in a Resolving Model of Pulmonary Infection. J Immunol, 2003, 171:5380-8.
    
    
12. S. Kotecha, R. J. Mildner, L. R. Prince, J. R. Vyas, A. E. Currie, R. A. Lawson, M. K. B. Whyte. The Role of Neutrophil Apoptosis in the Resolution of Acute Lung Injury in Newborn Infants. Thorax, 2003, 5:961-7.
    
    
13. I. Sabroe, L. R. Prince, E. C. Jones, M. J. Horsburgh, S. J. Foster, S. N. Vogel, S. K. Dower, and M. K. B Whyte. Selective Roles for TLR2 and TLR4 in the Regulation of Neutrophil Activation and Lifespan. J Immunol, 2003, 170, 5268-5275.
    
    
14. I. Sabroe, E. C. Jones, L. R. Usher, M. K. B. Whyte, and S. K. Dower. Toll-Like Receptor (TLR)2 and TLR4 in Human Peripheral Blood Granulocytes: A Critical Role for Monocytes in Leukocyte Lipopolysaccharide Responses. J Immunol, 2002, 168: 4701–4710.
    
    
15. L. R. Usher, R A. Lawson, I Geary, C J. Taylor, C D. Bingle, G W. Taylor, and M K.B. Whyte. Induction of Neutrophil Apoptosis by the Pseudomonas aeruginosa Exotoxin Pyocyanin: A Potential Mechanism of Persistent Infection. J Immunol, 2002, 168: 1861–1868.
    
    
16. S. A. Renshaw, S. J. Timmons, V. Eaton, L. R. Usher, M. Akil, C. D. Bingle, M. K.B. Whyte. Inflammatory Neutrophils Retain Susceptibility to Apoptosis Mediated via the Fas Death Receptor. J Leukoc Biol, 2000, 67(5):662-8.