Dr Lynne Prince MSc PhD
Department of Infection and Immunity
The University of Sheffield Medical School
Beech Hill Road
Tel: +44 (0)114 271 2578
Fax: +44 (0)114 226 8898
I graduated from Newcastle University in 1997 with a degree in medical microbiology. I then studied for the MSc in pathological sciences at the University of Sheffield (1999) which led to my PhD entitled `The regulation of neutrophil apoptosis by bacterial products´ (2003). In 2004 I was awarded a University of Sheffield Russell Research Fellowship to study the molecular mechanisms of neutrophil activation and apoptosis. My scientific mentors are Professor Moira Whyte and Professor Ian Sabroe (Infection and Immunity).
Inflammation and inflammatory diseases such as chronic obstructive pulmonary disease, or rheumatoid arthritis are extremely difficult to treat effectively. During inflammation, inflammatory cells, in particular neutrophils and monocytes, are thought to be key mediators of both tissue damage and perpetuation of further inflammatory signalling.
My research focuses on the role of neutrophils during infection and inflammation, and how their inflammatory potential and function is regulated by apoptosis. In particular, a collaboration with the University of Cardiff explores the cellular basis of inflammation in the preterm lung and partnerships with Professor Simon Foster and Dr Lynda Partridge (MBB) allow my group to study interactions between neutrophils and Staphylococcus aureus. Studying the roles of neutrophils in vivo is carried out in collaboration with Professor Steve Renshaw, using zebrafish models of inflammation (Infection and Immunity & MRC Centre for Developmental and Biomedical Genetics).
- I am a member of the Society for Leukocyte Biology and the British Society for Immunology.
- 2014-2016 British Lung Foundation project grant to study "The regulation of inflammatory signalling in human macrophages in the context of COPD" (Dr Lynne Prince, Prof Ian Sabroe).
- 2014-2016 Commonwealth Studentship to study "Dysregulated neutrophil function in COPD" (Dr Lynne Prince, Prof David Dockrell, Prof Moira Whyte).
- 2013-2016 University of Sheffield Florey Studentship “Identifying novel immune modulating factors in a genome-wide S. aureus screen in primary human leukocytes” (Dr Lynne Prince, Prof Simon Foster, MBB).
- 2013-2016 University of Sheffield Faculty studentship “The expression and roles of tetraspanins in human neutrophils” (Dr Lynne Prince, Dr Linda Partridge, MBB)
- 2013-2014 University of Sheffield BMedSci studentship “Immune signaling in human macrophages, exploring roles for Pellino 1” (Dr Lynne Prince, Prof Ian Sabroe).
- 2010-2013 MRC PhD studentship “The role of Hax1 in regulating myeloid cell survival in vitro and in vivo” (Dr Lynne Prince, Prof Steve Renshaw).
For Key Publications see below. For a full list of publications click here.
- Prince LR, Maxwell NC, Gill SK, Dockrell DH, Sabroe I, McGreal EP, Kotecha S & Whyte MK (2014) Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease. PLoS ONE, 9(8). View this article in White Rose Research Online
- Basran A, Jabeen M, Bingle L, Stokes CA, Dockrell DH, Whyte MK, Walmsley SR, Higgins KR, Vogel SN, Wilson HL, Prince LR, Prestwich EC, Sabroe RA, Parker LC & Sabroe I (2013) Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.. J Leukoc Biol, 93(1), 7-19.
- Bennett JA, Prince LR, Parker LC, Stokes CA, de Bruin HG, van den Berge M, Heijink IH, Whyte MK & Sabroe I (2012) Pellino-1 selectively regulates epithelial cell responses to rhinovirus.. J Virol, 86(12), 6595-6604.
- Prince LR, Graham KJ, Connolly J, Anwar S, Ridley R, Sabroe I, Foster SJ & Whyte MK (2012) Staphylococcus aureus induces eosinophil cell death mediated by α-hemolysin.. PLoS One, 7(2), e31506.
- Prince LR, Whyte MK, Sabroe I & Parker LC (2011) The role of TLRs in neutrophil activation. CURR OPIN PHARMACOL, 11(4), 397-403. View this article in White Rose Research Online
- Uddin M, Nong G, Ward J, Seumois G, Prince LR, Wilson SJ, Cornelius V, Dent G & Djukanovic R (2010) Prosurvival activity for airway neutrophils in severe asthma. THORAX, 65(8), 684-689.
- Anwar S, Prince LR, Foster SJ, Whyte MK & Sabroe I (2009) The rise and rise of Staphylococcus aureus: laughing in the face of granulocytes.. Clin Exp Immunol, 157(2), 216-224.
- Dick EP, Prince LR, Prestwich EC, Renshaw SA, Whyte MK & Sabroe I (2009) Pathways regulating lipopolysaccharide-induced neutrophil survival revealed by lentiviral transduction of primary human neutrophils.. Immunology, 127(2), 249-255.
- Dick EP, Prince LR & Sabroe I (2008) Ex vivo-expanded bone marrow CD34+ derived neutrophils have limited bactericidal ability.. Stem Cells, 26(10), 2552-2563.
- Prince LR, Bianchi SM, Vaughan KM, Bewley MA, Marriott HM, Walmsley SR, Taylor GW, Buttle DJ, Sabroe I, Dockrell DH & Whyte MK (2008) Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin.. J Immunol, 180(5), 3502-3511. View this article in White Rose Research Online
- Bianchi SM, Prince LR, McPhillips K, Allen L, Marriott HM, Taylor GW, Hellewell PG, Sabroe I, Dockrell DH, Henson PW & Whyte MK (2008) Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa.. Am J Respir Crit Care Med, 177(1), 35-43. View this article in White Rose Research Online
- Parker LC, Jones EC, Prince LR, Dower SK, Whyte MK & Sabroe I (2005) Endotoxin tolerance induces selective alterations in neutrophil function.. J Leukoc Biol, 78(6), 1301-1305.
- Prince LR, Allen L, Jones EC, Hellewell PG, Dower SK, Whyte MK & Sabroe I (2004) The role of interleukin-1beta in direct and toll-like receptor 4-mediated neutrophil activation and survival.. Am J Pathol, 165(5), 1819-1826.
- Kotecha S, Mildner RJ, Prince LR, Vyas JR, Currie AE, Lawson RA & Whyte MKB (2003) The role of neutrophil apoptosis in the resolution of acute lung injury in newborn infants. THORAX, 58(11), 961-967.
- Sabroe I, Prince LR, Jones EC, Horsburgh MJ, Foster SJ, Vogel SN, Dower SK & Whyte MK (2003) Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span.. J Immunol, 170(10), 5268-5275.
- usher L, Lawson RA, Geary I, Taylor CJ, Bingle CD, Taylor GW & Whyte MK () Induction of neutrophil apoptosis by the Pseudomonas aeruginosa exotoxin pyocyanin: a potential mechanism of persistent infection..