Dr Peter Peachell BSc PhD

Senior Lecturer in Pharmacology

Academic Unit of Respiratory Medicine
Department of Infection and Immunity
L Floor
The University of Sheffield Medical School
Beech Hill Road
Sheffield S10 2RX

Tel: +44 (0)114 271 2063
Fax: +44 (0)114 226 8898
Email: p.t.peachell@sheffield.ac.uk
Secretary - Mrs Jenny Earl
Tel: +44 (0)114 226 1458
Email: j.earl@sheffield.ac.uk

Biography

Before coming to the University of Sheffield, I obtained a First Class Honours degree in Chemistry (University College London), a PhD in Biological Chemistry (University College London) and a post-doctoral fellowship in Clinical Immunology (Johns Hopkins Medical School). I joined the University of Sheffield in 1992 as a Lecturer in Pharmacology and have been a Senior Lecturer since 2003, and over this period I have developed a strong research interest linked to the study of allergic mechanisms largely in the context of asthma. In particular, research in the laboratory has been focused on the pharmacological regulation of human lung mast cells. Research in the laboratory is funded by industrial sponsors (Pfizer, Novartis) and charitable trusts (Asthma UK).

Research Interests

  • Regulation of human lung mast cell responses by the beta-2-adrenoceptor.
  • Desensitization of human lung mast cell beta-2-adrenoceptors.
  • Pharmacogenetics of beta-2-adrenoceptor expression and function.
  • Regulation of mast cell responses by prostanoids.
  • Characterization and role of the protein kinase, syk, in human mast cells.
  • Characterization of phosphodiesterases in human mast cells and basophils.

Teaching Interests

  • Immunopharmacology
  • Autacoids
  • Medicinal chemistry

Current Projects

  • Role of protein tyrosine kinases (syk) and protein phosphatases (SHIP, PTEN) in regulating mast cell releasability.
  • Characterization of the receptor that mediates the inhibitory effects of prostaglandin E2 on mast cells.
  • Investigating the effects of long-acting beta agonists on mast cells.
  • Modulation of eicosanoid biosynthesis from mast cells.
  • Characterization of immune receptors expressed by mast cells.
  • Characterization of lung macrophage heterogeneity.
  • Regulation of human lung mast cell responses by the beta2-adrenoceptor
  • Desensitization of human lung mast cell beta2-adrenoceptors
  • Pharmacogenetics of beta2-adrenoceptor expression and function
  • Characterization of phosphodiesterases in human mast cells and basophils
  • Characterizaton and role of protein phosphatases in human mast cells and basophils

Publications

For Key Publications see below.  For a full list of publications click here.

Journal articles

Conferences

  • Scola A, Chong LK & Peachell PT (2003) Desensitisation of beta(2)-adrenoceptor-mediated responses by salbutamol and salmeterol in human lung mast cells. BRITISH JOURNAL OF PHARMACOLOGY, Vol. 138 (pp U68-U68)