Dr Peter Peachell BSc PhD

Senior Lecturer in Pharmacology

Academic Unit of Respiratory Medicine
Department of Infection and Immunity
L Floor
The University of Sheffield Medical School
Beech Hill Road
Sheffield S10 2RX

Tel: +44 (0)114 271 2063
Fax: +44 (0)114 226 8898
Email: p.t.peachell@sheffield.ac.uk
Secretary - Mrs Jenny Earl
Tel: +44 (0)114 226 1458
Email: j.earl@sheffield.ac.uk

Biography

Before coming to the University of Sheffield, I obtained a First Class Honours degree in Chemistry (University College London), a PhD in Biological Chemistry (University College London) and a post-doctoral fellowship in Clinical Immunology (Johns Hopkins Medical School). I joined the University of Sheffield in 1992 as a Lecturer in Pharmacology and have been a Senior Lecturer since 2003, and over this period I have developed a strong research interest linked to the study of allergic mechanisms largely in the context of asthma. In particular, research in the laboratory has been focused on the pharmacological regulation of human lung mast cells. Research in the laboratory is funded by industrial sponsors (Pfizer, Novartis) and charitable trusts (Asthma UK).

Research Interests

  • Regulation of human lung mast cell responses by the beta-2-adrenoceptor.
  • Desensitization of human lung mast cell beta-2-adrenoceptors.
  • Pharmacogenetics of beta-2-adrenoceptor expression and function.
  • Regulation of mast cell responses by prostanoids.
  • Characterization and role of the protein kinase, syk, in human mast cells.
  • Characterization of phosphodiesterases in human mast cells and basophils.

Teaching Interests

  • Immunopharmacology
  • Autacoids
  • Medicinal chemistry

Current Projects

  • Role of protein tyrosine kinases (syk) and protein phosphatases (SHIP, PTEN) in regulating mast cell releasability.
  • Characterization of the receptor that mediates the inhibitory effects of prostaglandin E2 on mast cells.
  • Investigating the effects of long-acting beta agonists on mast cells.
  • Modulation of eicosanoid biosynthesis from mast cells.
  • Characterization of immune receptors expressed by mast cells.
  • Characterization of lung macrophage heterogeneity.
  • Regulation of human lung mast cell responses by the beta2-adrenoceptor
  • Desensitization of human lung mast cell beta2-adrenoceptors
  • Pharmacogenetics of beta2-adrenoceptor expression and function
  • Characterization of phosphodiesterases in human mast cells and basophils
  • Characterizaton and role of protein phosphatases in human mast cells and basophils

Key Publications (recent)

  1. Chong LK, Chowdry J, Ghahramani P and Peachell PT (2000). Influence of genetic polymorphisms in the beta-2-adrenoceptor on desensitization in human lung mast cells. Pharmacogenetics 10: 153-162.
  2. Bastan R, Peirce MJ and Peachell PT (2001). Regulation of immunoglobulin E-mediated secretion by protein phosphatases in human basophils and mast cells of skin and lung. Eur J Pharmacol 430: 135-141.
  3. Chong LK, Suvarna K, Chess-Williams R and Peachell PT (2003). Desensitization of beta-2-adrenoceptor-mediated responses by short-acting beta-2-adrenoceptor agonists in human lung mast cells. Br J Pharmacol 138: 512-520.
  4. Eskanadari N, Wickramasinghe T and Peachell PT (2004). Effects of phosphodiesterase inhibitors on interleukin-4 and interleukin-13 generation from human basophils. Br J Pharmacol 142: 1265-1272.
  5. Scola A-M, Chong LK, Suvarna SK, Chess-Williams R and Peachell PT (2004). Influence of agonist intrinsic activity on the desensitization of beta-2-adrenoceptor-mediated responses in mast cells. Br J Pharmacol 143: 71-80.
  6. Peachell PT (2005). Targeting the mast cell in asthma. Curr Opin Pharmacol 5: 251-256
  7. Kay LJ, Yeo WW and Peachell PT (2006). Prostaglandin E2 activates EP2 receptors to inhibit human lung mast cell degranulation. Br J Pharmacol 147: 707-713.
  8. Harrison CA, Bastan R, Peirce MJ, Munday MR and Peachell PT (2007). Role of calcineurin in the regulation of human lung mast cell and basophil function by cyclosporine and FK506. Br J Pharmacol 150: 509-518.
  9. Kay LJ, Rostami-Hodjegan A, Suvarna SK and Peachell PT (2007). Influence of beta-2-adrenoceptor gene polymorphisms on beta-2-adrenoceptor-mediated responses in human lung mast cells. Br J Pharmacol 152: 323-331.
  10. Scola AM, Loxham M, Charlton SJ and Peachell PT (2009). The long-acting beta-agonist, indacaterol, inhibits IgE-dependent human lung mast cell responses. Br J Pharmacol 158: 267-276.