Dr Lisa Parker BSc MRes PhD
Lecturer in Inflammation Biology
Academic Unit of Respiratory Medicine
Department of Infection and Immunity
The University of Sheffield Medical School
Beech Hill Road
I joined the University of Manchester in 1993 and obtained a BSc (First Class Honours) degree (1996) and MRes (1997) within the Department of Neuroscience. I then completed an MRC funded PhD(2000), investigating `Interleukin-1 and its receptors in the brain´, under the supervision of Professor Dame Nancy Rothwell.
I moved to the University of Sheffield in 2001 where, maintaining my interest in inflammatory mechanisms in disease, I obtained a post-doctoral position (funded by the ARC) working with Professor Ian Sabroe in the Department of Infection and Immunity. My research interests now focussed on Toll-like receptors (TLRs), which show many common features with IL-1 receptors, and their role in inflammation in the lung. I remained in Sheffield taking up a second post-doctoral position (MRC-funded) to continue my research into airway inflammation.
I am currently a Lecturer in Inflammation Biology within the Department of Infection and Immunity (2010-present).
Airway inflammation in response to pathogens
Bacterial and viral pathogens are a major trigger of acute exacerbations in asthma and chronic obstructive pulmonary disease (COPD). Pathogens are detected by Toll-Like receptors (TLRs), a family of receptors that regulate cell activation, however the mechanisms through which pathogens initiate airway exacerbations remain inadequately defined. My current research aims to identify how leukocytes influence the ability of pathogens to infect and trigger proinflammatory responses in airway epithelial cells. A more complete understanding of the host innate immune responses and complex signalling pathways that are triggered in the course of chronic inflammation, and during single or multiple infections, will lead to the elucidation of novel therapeutic targets and approaches to manage airway inflammation.
- Member of the Society for Leukocyte Biology.
- Science and Engineering Ambassador (STEMNET programme)
- 2014-2017 Asthma UK PhD studentship "Investigating the role of tenascin-C in rhinovirus-induced acute exacerbations of asthma". Lead applicant, co-applicants Dr Kim Midwood (Oxford University), Dr Michael Edwards (Imperial College London), Prof Ian Sabroe.
- 2014-2017 University of Sheffield PhD studentship "Phosphatases and respiratory viral infection". Lead applicant, co-applicant Prof Ian Sabroe.
- 2014-2017 Medical Research Council Project Grant "The role of pellino proteins in viral inflammation". Name collaborator, lead applicants Prof Ian Sabroe, Prof David Dockrell.
- 2013-2016 Medical Research Council New Investigator Research Grant "Probing the sequence of cellular activation by rhinoviral infection in the airway and identifying how this may be dysregulated in COPD". Lead applicant.
- 2010-2014 BBSRC Industrial CASE PhD studentship in collaboration with GSK "The TLR-mediated interrelationship of Interleukin-1 and Interferon Signalling during chronic airway inflammation". Lead applicant, co-applicants Prof Ian Sabroe, Dr Karen Simpson, Dr Stuart Farrow.
- 2010-2014 Wellcome Trust project grant "Inhibiting TLR signalling by disruption of membrane microdomains". Co-applicant, lead applicant Prof Ian Sabroe, co-applicants Prof David Dockrell, Prof John Harwood (University of Cardiff).
For Key Publications see below. For a full list of publications click here.
- Parker LC, Stokes CA & Sabroe I (2014) Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells.. Clin Exp Allergy, 44(1), 20-28.
- Sabroe RA, Stokes CA, Parker LC, Higgins KR, Prince LR & Sabroe I (2013) Muckle-Wells syndrome without mutation in exon 3 of the NLRP3 gene, identified by evidence of excessive monocyte production of functional interleukin 1β and rapid response to anakinra. Clinical and Experimental Dermatology, 38(8), 874-877.
- Piper SC, Ferguson J, Kay L, Parker LC, Sabroe I, Sleeman MA, Briend E & Finch DK (2013) The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells.. PLoS One, 8(5), e63365.
- Basran A, Jabeen M, Bingle L, Stokes CA, Dockrell DH, Whyte MK, Walmsley SR, Higgins KR, Vogel SN, Wilson HL, Prince LR, Prestwich EC, Sabroe RA, Parker LC & Sabroe I (2013) Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.. J Leukoc Biol, 93(1), 7-19.
- Chaudhuri N, Jary H, Lea S, Khan N, Piddock KC, Dockrell DH, Donaldson K, Duffin R, Singh D, Parker LC & Sabroe I (2012) Diesel exhaust particle exposure in vitro alters monocyte differentiation and function.. PLoS One, 7(12), e51107.
- Bennett JA, Prince LR, Parker LC, Stokes CA, de Bruin HG, van den Berge M, Heijink IH, Whyte MK & Sabroe I (2012) Pellino-1 selectively regulates epithelial cell responses to rhinovirus.. J Virol, 86(12), 6595-6604.
- Prince LR, Whyte MK, Sabroe I & Parker LC (2011) The role of TLRs in neutrophil activation. CURR OPIN PHARMACOL, 11(4), 397-403. View this article in White Rose Research Online
- Stokes CA, Ismail S, Dick EP, Bennett JA, Johnston SL, Edwards MR, Sabroe I & Parker LC (2011) Role of interleukin-1 and MyD88-dependent signaling in rhinovirus infection.. J Virol, 85(15), 7912-7921. View this article in White Rose Research Online
- Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I, Dockrell DH, Milo M, Taylor CT, Johnson RS, Pugh CW, Ratcliffe PJ, Maxwell PH, Carmeliet P & Whyte MK (2011) Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.. J Clin Invest, 121(3), 1053-1063. View this article in White Rose Research Online
- Ward JR, West PW, Ariaans MP, Parker LC, Francis SE, Crossman DC, Sabroe I & Wilson HL (2010) Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms.. J Biol Chem, 285(30), 23147-23158.
- Chaudhuri N, Paiva C, Donaldson K, Duffin R, Parker LC & Sabroe I (2010) Diesel exhaust particles override natural injury-limiting pathways in the lung.. Am J Physiol Lung Cell Mol Physiol, 299(2), L263-L271.
- Parker LC, Prince LR, Buttle DJ & Sabroe I (2009) The generation of highly purified primary human neutrophils and assessment of apoptosis in response to Toll-like receptor ligands.. Methods Mol Biol, 517, 191-204.
- Parker LC, Prestwich EC, Ward JR, Smythe E, Berry A, Triantafilou M, Triantafilou K & Sabroe I (2008) A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains.. J Immunol, 181(8), 5606-5617.
- West PW, Parker LC, Ward JR & Sabroe I (2008) Differential and cell-type specific regulation of responses to Toll-like receptor agonists by ISO-1.. Immunology, 125(1), 101-110.
- Sabroe I, Parker LC, Dower SK & Whyte MK (2008) The role of TLR activation in inflammation.. J Pathol, 214(2), 126-135.
- Sabroe I, Parker LC, Dower SK & Whyte MK (2007) Practical and conceptual models of chronic obstructive pulmonary disease.. Proc Am Thorac Soc, 4(8), 606-610.
- Sabroe I, Parker LC, Calverley PM, Dower SK & Whyte MK (2007) Pathological networking: a new approach to understanding COPD.. Thorax, 62(8), 733-738.
- Morris GE, Parker LC, Ward JR, Jones EC, Whyte MK, Brightling CE, Bradding P, Dower SK & Sabroe I (2006) Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.. FASEB J, 20(12), 2153-2155.
- Parker LC, Jones EC, Prince LR, Dower SK, Whyte MK & Sabroe I (2005) Endotoxin tolerance induces selective alterations in neutrophil function.. J Leukoc Biol, 78(6), 1301-1305.
- Parker LC, Whyte MK, Dower SK & Sabroe I (2005) The expression and roles of Toll-like receptors in the biology of the human neutrophil.. J Leukoc Biol, 77(6), 886-892.
- Parker LC, Whyte MK, Vogel SN, Dower SK & Sabroe I (2004) Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells.. J Immunol, 172(8), 4977-4986.
- Pinteaux E, Parker LC, Rothwell NJ & Luheshi GN (2002) Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells.. J Neurochem, 83(4), 754-763.
- Sabroe I, Parker LC, Wilson AG, Whyte MK & Dower SK (2002) Toll-like receptors: their role in allergy and non-allergic inflammatory disease.. Clin Exp Allergy, 32(7), 984-989.
- Parker LC, Luheshi GN, Rothwell NJ & Pinteaux E (2002) IL-1 beta signalling in glial cells in wildtype and IL-1RI deficient mice.. Br J Pharmacol, 136(2), 312-320.
- Touzani O, Boutin H, LeFeuvre R, Parker L, Miller A, Luheshi G & Rothwell N (2002) Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor.. J Neurosci, 22(1), 38-43.
- Parker LC, Rushforth DA, Rothwell NJ & Luheshi GN (2000) IL-1beta induced changes in hypothalamic IL-1R1 and IL-1R2 mRNA expression in the rat.. Brain Res Mol Brain Res, 79(1-2), 156-158.
- Allan SM, Parker LC, Collins B, Davies R, Luheshi GN & Rothwell NJ (2000) Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat.. Proc Natl Acad Sci U S A, 97(10), 5580-5585.
- Allan SM, Parker LC, Grundy RI & Collins B (2000) Site-specific actions of interleukin-1 in neurodegeneration. PHARMACOLOGY OF CEREBRAL ISCHEMIA 2000 (pp 425-431)