The University of Sheffield
Department of Infection and Immunity

Professor Albert Ong DM MA FRCP

Professor of Renal Medicine

Dr Ong

Academic Unit of Nephrology
Department of Infection and Immunity
The University of Sheffield Medical School
Beech Hill Road
Sheffield
S10 2RX
United Kingdom

Tel: +44 (0)114 271 3402
Fax:: +44 (0)114 271 1711
Email: a.ong@sheffield.ac.uk
Secretary: Ms Jean Lazenby
Tel: +44 (0)114 271 2237
Fax: +44 (0)114 271 3892
Email: j.lazenby@sheffield.ac.uk

Biography

I am Professor of Renal Medicine and Head of the Academic Unit of Nephrology at the University of Sheffield. After graduating in medicine from the University of Oxford, I underwent postgraduate clinical training in medicine and nephrology at University College London and Oxford. My research career started as a Clinical Lecturer at the Department of Medicine at UCL. I was then awarded a Kidney Research UK Senior Research Fellowship to work under the mentorship of Dr Peter Harris and Sir David Weatherall at the MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford.

I received the AEG Raine and CM Lockwood awards from the Renal Association (UK) and a personal Research Leave Fellowship from the Wellcome Trust. I have published over 80 original papers and book chapters in leading journals such as the Lancet, BMJ, PNAS and the EMBO Journal. My research interests are in the impact of the new genetics on kidney disease and in the genetic basis of cystic kidney disease.

Research Interests

KGG logo

I lead the Kidney Genetics Group at the University of Sheffield. Its major research interests are in the molecular genetics, cell biology and pathogenesis of autosomal dominant polycystic kidney disease (ADPKD). In particular, we aim to discover new treatments for ADPKD, to understand better how cysts form and grow in the ADPKD kidney and to improve the clinical management of ADPKD patients.

ADPKD is one of the most common monogenic human diseases known and affects around 1 in 500 people. It is caused by mutations in two genes, PKD1 and PKD2. ADPKD accounts for ~10% of patients with kidney failure in most renal units and affects up to 10 million people worldwide. It is also a major cause of sudden death and disability in younger patients due to intracranial aneurysm rupture.

Teaching Interests

My educational interests concern the support and development of nephrology in the developing world. I chair the International Committee of the Renal Association and am an Educational Ambassador of the International Society of Nephrology.

Professional Activities

Current Projects

We have taken several experimental approaches to studying ADPKD including:

  1. Investigating structure-function relationships of the ADPKD proteins, polycystin-1 and polycystin-2.
  2. The role of post-translational modification in regulating polycystin protein function.
  3. Using experimental models to understand the natural history of disease and to test novel compounds.
  4. Pathogenesis of the cardiovascular phenotype in ADPKD.
  5. Clinical, genetic and epigenetic factors determining renal disease progression in ADPKD patients.

We have a number of active international collaborations. Our work is currently supported by the Wellcome Trust, the Medical Research Council, Research Councils (UK), Kidney Research UK, the Polycystic Kidney disease foundation (USA), the Sheffield Kidney Research Foundation (SKRF), The Sheffield Area Kidney Patients Association (SAKA) and the Polycystic Kidney Disease Charity (UK).

Publications

For key publications see below.  For a full list of publications click here.

Journal articles