Dr Helen Marriott PhD
Department of Infection and Immunity
K Floor, (Office K105)
The University of Sheffield Medical School
Beech Hill Road
Tel: +44 (0)114 271 2181
Fax: +44 (0)114 226 8898
I joined the University of Sheffield in 1995 from the Department of Respiratory Physiology, Papworth Hospital, Cambridge. From 1995 to 2001 my research was on the pulmonary circulation, focusing on animal models of pulmonary hypertension. This formed the basis of my PhD, "Pulmonary hypertension: susceptibility and treatment in rat models".
In 2001 I joined Professor David Dockrell´s group as a post-doctoral research associate investigating the role of macrophage apoptosis in pneumococcal infection. In 2005 I was awarded an independent fellowship from the British Lung Foundation to investigate the effects of influenza A virus on macrophage innate immune function.
My main research interest is in the role of macrophages in host defense against respiratory pathogens, in particular Streptococcus pneumoniae. Additionally, I am interested in the effect of influenza A virus on macrophage function, its effect on the regulation of macrophage apoptosis and how this may lead to increased susceptibility to bacterial superinfections. I have been using a variety of in vitro and in vivo models and am currently developing computational models to support this research.
My main collaboration is with Professor David Dockrell. I also collaborate on murine in vivo models with Professor Moira Whyte, Dr Sarah Walmsley and Dr Colin Bingle. My work on the development of computational models is in collaboration with Dr Alex Best (Mathematics and Statistics), Professor Rod Smallwood (Computer Science) and Professor Mike Boots (University of Exeter).
My main teaching interest is in supporting the development of strong fundamental research skills in students. I contribute to several modules in the MSc in Molecular Medicine, I am module leader for the Experimental Medicine pathway modules 'Molecular and Cellular Basis of Disease' and 'Model Systems in Medical Research', and the Microbes and Infection pathway module 'Pathogenicity of Viruses and Fungi'. I also teach on the Postgraduate Induction course of the Faculty of Medicine, Dentistry and Health.
- Committee member of the British Association for Lung Research.
- Member of University of Sheffield ethical review panel/3Rs Committee.
- Computational models of macrophage innate immune responses to Staphylococcus aureus.
- Role of ubiquitination in regulation of macrophage viability after bacterial infection.
- The role of apoptosis in murine models of pneumococcal pneumonia.
For Key Publications see below. For a full list of publications click here.
- Thompson AA, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE, Formenti F, Van Eeden FJ, Kinnula VL, Pugh CW, Sabroe I, Dockrell DH, Chilvers ER, Robbins PA, Percy MJ, Simon MC, Johnson RS, Renshaw SA, Whyte MK & Walmsley SR (2014) Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.. Blood, 123(3), 366-376.
- Bewley MA, Naughton M, Preston J, Mitchell A, Holmes A, Marriott HM, Read RC, Mitchell TJ, Whyte MK & Dockrell DH (2014) Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation.. mBio, 5(5).
- Daigneault M, de Silva TI, Bewley MA, Preston JA, Marriott HM, Mitchell AM, Mitchell TJ, Read RC, Whyte MKB & Dockrell DH (2012) Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. PLoS Pathogens, 8(7), 30-30.
- Marriott HM, Daigneault M, Thompson AAR, Walmsley SR, Gill SK, Witcher DR, Wroblewski VJ, Hellewell PG, Whyte MKB & Dockrell DH (2012) A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia. Thorax, 67(11), 985-992.
- McGrath EE, Lawrie A, Marriott HM, Mercer P, Cross SS, Arnold N, Singleton V, Thompson AAR, Walmsley SR, Renshaw SA, Sabroe I, Chambers RC, Dockrell DH & Whyte MKB (2012) Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis. Thorax, 67(9), 796-803.
- Marriott HM, Gascoyne KA, Gowda R, Geary I, Nicklin MJ, Iannelli F, Pozzi G, Mitchell TJ, Whyte MK, Sabroe I & Dockrell DH (2012) Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages.. Infect Immun, 80(3), 1140-1149. View this article in White Rose Research Online
- McGrath EE, Marriott HM, Lawrie A, Francis SE, Sabroe I, Renshaw SA, Dockrell DH & Whyte MK (2011) TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation.. J Leukoc Biol, 90(5), 855-865. View this article in White Rose Research Online
- Bewley MA, Pham TK, Marriott HM, Noirel J, Chu HP, Ow SY, Ryazanov AG, Read RC, Whyte MK, Chain B, Wright PC & Dockrell DH (2011) Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae.. Mol Cell Proteomics, 10(6), M111.008193. View this article in White Rose Research Online
- Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I, Dockrell DH, Milo M, Taylor CT, Johnson RS, Pugh CW, Ratcliffe PJ, Maxwell PH, Carmeliet P & Whyte MK (2011) Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.. J Clin Invest, 121(3), 1053-1063. View this article in White Rose Research Online
- Bewley MA, Marriott HM, Tulone C, Francis SE, Mitchell TJ, Read RC, Chain B, Kroemer G, Whyte MK & Dockrell DH (2011) A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.. PLoS Pathog, 7(1), e1001262. View this article in White Rose Research Online
- Webster SJ, Daigneault M, Bewley MA, Preston JA, Marriott HM, Walmsley SR, Read RC, Whyte MK & Dockrell DH (2010) Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease.. J Immunol, 185(5), 2968-2979.
- Daigneault M, Preston JA, Marriott HM, Whyte MK & Dockrell DH (2010) The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages.. PLoS One, 5(1), e8668. View this article in White Rose Research Online
- Marriott HM, Jackson LE, Wilkinson TS, Simpson AJ, Mitchell TJ, Buttle DJ, Cross SS, Ince PG, Hellewell PG, Whyte MK & Dockrell DH (2008) Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia.. Am J Respir Crit Care Med, 177(8), 887-895. View this article in White Rose Research Online
- Marriott HM, Hellewell PG, Cross SS, Ince PG, Whyte MK & Dockrell DH (2006) Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia.. J Immunol, 177(9), 6480-6488. View this article in White Rose Research Online
- Tunbridge AJ, Stevanin TM, Lee M, Marriott HM, Moir JW, Read RC & Dockrell DH (2006) Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms.. Infect Immun, 74(1), 729-733.
- Marriott HM, Bingle CD, Read RC, Braley KE, Kroemer G, Hellewell PG, Craig RW, Whyte MKB & Dockrell DH (2005) Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance. J CLIN INVEST, 115(2), 359-368. View this article in White Rose Research Online
- Marriott HM, Ali F, Read RC, Mitchell TJ, Whyte MK & Dockrell DH (2004) Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection.. FASEB J, 18(10), 1126-1128. View this article in White Rose Research Online
- Dockrell DH, Marriott HM, Prince LR, Ridger VC, Ince PG, Hellewell PG & Whyte MK (2003) Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection.. J Immunol, 171(10), 5380-5388. View this article in White Rose Research Online