Professor Andrew Heath

Professor of Cellular Immunology

Department of Infection and Immunity
L Floor
The University of Sheffield Medical School
Beech Hill Road
SHEFFIELD
S10 2RX
United Kingdom

Tel: +44 (0)114 226 8634
Fax: +44 (0)114 226 8898
Email: a.w.heath@sheffield.ac.uk
Secretary - Jean Lazenby
Tel: +44 (0)114 271 2237
Email: j.lazenby@sheffield.ac.uk

Biography

I joined the University of Sheffield in 1994 having worked for 5 years in California, first at a start up parasite vaccine company, Paravax, and then at DNAX Inc. in Palo Alto. Prior to that I had post-doctoral positions in the Departments of Immunology at St GeorgeĀ“s and the Middlesex Hospital Medical Schools in London.

Research Interests

My research interests are centred on methods of enhancing immune responses to vaccination. Vaccines have massive potential not only ion the traditional areas of prevention of infectious diseases, but also as treatments for cancer and other non-infectious diseases. To fulfil this potential, immunogenicity needs to be increased, and immunological adjuvants need to be developed.  We have developed and patented two novel immunological adjuvants and are currently working on two more, one with the Thomas group and the other with the Sayers group in Sheffield.

A second interest is in investigating the causes of vaccine non-responsiveness which happens with some individuals.  We are particularly interested in subtle immune defects leading to susceptibility to infections with encapsulated bacteria such as Neisseria meningitidis and Streptococcus pneumoniae in both vaccinated and non-vaccinated individuals.  This work is in conjunction with Dr Thushan de Silva and with the Florey Institute in Sheffield.

Teaching Interests

I am the module leader for the MSc in Molecular Medicine Module "Modulating Immunity". I also teach on the MBChB course and am co-organiser for the new phase 2 immunology module with Dr Munitta Muthana.

Current Projects

  • Lymphoma Vaccine - work on a therapeutic vaccine for B lymphoma funded by Adjuvantix Ltd.
  • A novel vaccine against Group B meningococcus (funded by Meningitis Now).
  • An investigation into the causes of increased susceptibility to pneumococcal infection in HIV patients even following highly active antiretroviral therapy (HAART) which has restored CD4 numbers (with Dr Thushan de Silva and the Florey Institute, Sheffield).

Publications

For Key Publications see below. For a full list of publications click here

Journal articles