Professor Andrew Heath
Professor of Cellular Immunology
Department of Infection and Immunity
The University of Sheffield Medical School
Beech Hill Road
I joined the University of Sheffield in 1994 having worked for 5 years in California, first at a start up parasite vaccine company, Paravax, and then at DNAX Inc. in Palo Alto. Prior to that I had post-doctoral positions in the Departments of Immunology at St George´s and the Middlesex Hospital Medical Schools in London.
My research interests are centred on methods of enhancing immune responses to vaccination. Vaccines have massive potential not only ion the traditional areas of prevention of infectious diseases, but also as treatments for cancer and other non-infectious diseases. To fulfil this potential, immunogenicity needs to be increased, and immunological adjuvants need to be developed. We have developed and patented two novel immunological adjuvants and are currently working on two more, one with the Thomas group and the other with the Sayers group in Sheffield.
A second interest is in investigating the causes of vaccine non-responsiveness which happens with some individuals. We are particularly interested in subtle immune defects leading to susceptibility to infections with encapsulated bacteria such as Neisseria meningitidis and Streptococcus pneumoniae in both vaccinated and non-vaccinated individuals. This work is in conjunction with Dr Thushan de Silva and with the Florey Institute in Sheffield.
I am the module leader for the MSc in Molecular Medicine Module "Modulating Immunity". I also teach on the MBChB course and am co-organiser for the new phase 2 immunology module with Dr Munitta Muthana.
- Lymphoma Vaccine - work on a therapeutic vaccine for B lymphoma funded by Adjuvantix Ltd.
- A novel vaccine against Group B meningococcus (funded by Meningitis Now).
- An investigation into the causes of increased susceptibility to pneumococcal infection in HIV patients even following highly active antiretroviral therapy (HAART) which has restored CD4 numbers (with Dr Thushan de Silva and the Florey Institute, Sheffield).
For Key Publications see below. For a full list of publications click here
- Preciado-Llanes L, Wing JB, Foster RA, Carlring J, Lees A, Read RC & Heath AW (2014) Contact dependent suppression of CD4 T cell activation and proliferation by B cells activated through IgD cross-linking.. Immunology.
- Wing JB, Smart L, Borrow R, Findlow J, Findlow H, Lees A, Foster RA, Carlring J, Read RC & Heath AW (2012) Correlation of group C meningococcal conjugate vaccine response with B- and T-lymphocyte activity.. PLoS One, 7(2), e31160.
- Carlring J, Szabo MJ, Dickinson R, De Leenheer E & Heath AW (2012) Conjugation of lymphoma idiotype to CD40 antibody enhances lymphoma vaccine immunogenicity and antitumor effects in mice.. Blood, 119(9), 2056-2065.
- Wing JB, Smart L, Borrow R, Findlow J, Findlow H, Heath AW & Read RC (2011) Kinetics of immune responses to nasal challenge with meningococcal polysaccharide one year after serogroup-C glycoconjugate vaccination.. Clin Infect Dis, 52(11), 1317-1323.
- Darton TC, Wing JB, Lees A, Heath AW & Read RC (2011) Adult survivors of invasive pneumococcal disease exhibit defective B cell function.. Clin Infect Dis, 52(9), 1133-1136.
- Carlring J, Altaher HM, Clark S, Chen X, Latimer SL, Jenner T, Buckle AM & Heath AW (2011) CD154-CD40 interactions in the control of murine B cell hematopoiesis.. J Leukoc Biol, 89(5), 697-706.
- Carlring J, De Leenheer E & Heath AW (2011) A novel redox method for rapid production of functional bi-specific antibodies for use in early pilot studies.. PLoS One, 6(7), e22533.
- Foster RA, Carlring J, Lees A, Borrow R, Ramsay M, Kacsmarski E, Miller E, McKendrick MW, Heath AW & Read RC (2010) Functional T-cell deficiency in adolescents who experience serogroup C meningococcal disease despite receiving the meningococcal serogroup C conjugate vaccine.. Clin Vaccine Immunol, 17(7), 1104-1110.
- Bhagawati-Prasad VN, De Leenheer E, Keefe NP, Ryan LA, Carlring J & Heath AW (2010) CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis.. J Immune Based Ther Vaccines, 8, 1.
- Foster RA, Carlring J, McKendrick MW, Lees A, Borrow R, Read RC & Heath AW (2009) Evidence of a functional B-cell immunodeficiency in adults who experience serogroup C meningococcal disease.. Clin Vaccine Immunol, 16(5), 692-698.
- Barr TA, McCormick AL, Carlring J & Heath AW (2003) A potent adjuvant effect of CD40 antibody attached to antigen.. Immunology, 109(1), 87-92.
- Randall TD, Heath AW, Santos-Argumedo L, Howard MC, Weissman IL & Lund FE (1998) Arrest of B lymphocyte terminal differentiation by CD40 signaling: Mechanism for lack of antibody-secreting cells in germinal centers. IMMUNITY, 8(6), 733-742.
- Dullforce P, Sutton DC & Heath AW (1998) Enhancement of T cell-independent immune responses in vivo by CD40 antibodies.. Nat Med, 4(1), 88-91.