The University of Sheffield
Department of Infection and Immunity

Dr Francois Guesdon


Department of Infection and ImmunityPhoto of Dr Francois Guesdon
K Floor
The University of Sheffield Medical School
Beech Hill Road
S10 2RX
United Kingdom

Tel: +44(0) 114 271 3437
Fax: +44(0) 114 271 8898
Secretary - Jean Lazenby
Tel: +44 (0)114 271 2237


After obtaining my PhD in 1989 I joined the group of Jeremy Saklatvala in Cambridge. I was appointed in Sheffield in 1996 and am currently Course Tutor of the Msc in Molecular Medicine.

Research Interests

My research interests are the signal transduction mechanisms of innate immunity cytokines such as IL-1, IL-17 or IL-25 and their roles in allergic (asthma) or chronic inflammatory diseases (arthritis).

Current Projects

Teaching Development and Innovation

MSc module Leader: I have designed, set up and led six MSc modules since 2000, of which three are currently taught in the MSc of Molecular Medicine and / or the MSc in Reproductive and Developmental Medicine.

Deputy Course Leader and Course Tutor of the MSc of Molecular Medicine:
Responsible for progress monitoring, student support, disciplinary matters and chairing examination board meetings.

Programme development and support:

Professional Recognition and Awards

2010 - University Senate Award for Excellence in Learning and Teaching (Collaboration category)

Key Publications

  1. Guesdon F, Kaabi Y, Riley AH, Wilkinson IR, Gray C, James DC, Artymiuk PJ, Sayers JR and Ross RJ. 2012. Expression of a glycosylphosphatidylinositol anchored ligand, growth hormone, blocks receptor signalling. Biosci. Rep. 32:653-660.
  2. Greetham D, Ellis CD, Mewar D, Fearon U, an Ultaigh SN, Veale DJ, Guesdon F, and Wilson AG. 2007. Functional characterization of NF-kappaB inhibitor-like protein 1 (NFkappaBIL1), a candidate susceptibility gene for rheumatoid arthritis. Hum Mol Genet 16(24):3027-36.
  3. Ross K, Yang L, Dower S, Volpe F, and Guesdon F. 2002. Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase. J Biol Chem 277(40):37414-21.
  4. Dempsey CE, Sakurai H, Sugita T, and Guesdon F, 2000. Alternative splicing and gene structure of the transforming growth factor beta-activated kinase 1. Biochim Biophys Acta. 1517(1):46-52.
  5. Guesdon, F, Knight CG, Rawlinson L and Saklatvala J. 1997. Dual specificity of the interleukin 1- and tumor necrosis factor- activated ß casein kinase. J. Biol. Chem. 272:30017-30024.
  6. Freshney NW, Rawlinson L, Guesdon, F, Jones E, Cowley S, Hsuan J, and Saklatvala J. 1994. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell 78(60):1039-49.