Dr Francois Guesdon
Academic Unit of Immunology and Infectious Diseases
Department of Infection and Immunity
The University of Sheffield Medical School
Beech Hill Road
Tel: +44(0) 114 271 3437
Fax: +44(0) 114 271 8898
Secretary - Jean Lazenby
Tel: +44 (0)114 271 2237
After obtaining my PhD in 1989 I joined the group of Jeremy Saklatvala in Cambridge. I was appointed in Sheffield in 1996 and am currently Course Tutor of the Msc in Molecular Medicine.
My research interests are the signal transduction mechanisms of innate immunity cytokines such as IL-1, IL-17 or IL-25 and their roles in allergic (asthma) or chronic inflammatory diseases (arthritis).
I have been involved in the development of three post-graduate taught programmes since 1999. My main contributions have been in the areas of syllabus design and student support.
- Induction of IL-25 expxression by airborne allergens
- Greetham D, Ellis CD, Mewar D, Fearon U, an Ultaigh SN, Veale DJ, Guesdon F, and Wilson AG. 2007. Functional characterization of NF-kappaB inhibitor-like protein 1 (NFkappaBIL1), a candidate susceptibility gene for rheumatoid arthritis. Hum Mol Genet 16(24):3027-36.
- Ross K, Yang L, Dower S, Volpe F, and Guesdon F. 2002. Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase. J Biol Chem 277(40):37414-21.
- Dempsey CE, Sakurai H, Sugita T, and Guesdon F, 2000. Alternative splicing and gene structure of the transforming growth factor beta-activated kinase 1. Biochim Biophys Acta. 1517(1):46-52.
- Freshney NW, Rawlinson L, Guesdon, F, Jones E, Cowley S, Hsuan J, and Saklatvala J. 1994. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell 78(60:1039-49.