Dr Francois Guesdon


Department of Infection and ImmunityPhoto of Dr Francois Guesdon
K Floor
The University of Sheffield Medical School
Beech Hill Road
S10 2RX
United Kingdom

Tel: +44(0) 114 271 3437
Fax: +44(0) 114 271 8898
Email: f.a.guesdon@sheffield.ac.uk
Secretary - Jean Lazenby
Tel: +44 (0)114 271 2237
Email: j.lazenby@sheffield.ac.uk


After obtaining my PhD in 1989 I joined the group of Jeremy Saklatvala in Cambridge. I was appointed in Sheffield in 1996 and am currently Course Tutor of the Msc in Molecular Medicine.

Research Interests

My research interests are the signal transduction mechanisms of innate immunity cytokines such as IL-1, IL-17 or IL-25 and their roles in allergic (asthma) or chronic inflammatory diseases (arthritis).

Current Projects

  • Induction of IL-25 expression by airborne allergens
  • Regulation of the protein kinase TAK1

Teaching Development and Innovation

MSc module Leader: I have designed, set up and led six MSc modules since 2000, of which three are currently taught in the MSc of Molecular Medicine and / or the MSc in Reproductive and Developmental Medicine.

Deputy Course Leader and Course Tutor of the MSc of Molecular Medicine:
Responsible for progress monitoring, student support, disciplinary matters and chairing examination board meetings.

Programme development and support:

  • 2000-present: I have designed, set up and led six MSc modules since 2000. I have also carried out yearly reviews of the contents, delivery formats and assessment of these modules and updated them when necessary.
  • 2005: Key contributor to the process of reviewing two overlapping MSc courses and fusing them into a single modular course (MSc in Molecular Medicine), launched in 2006-2007.
  • 2007-present: Designed and managed the personal tutoring scheme of the MSc in Molecular Medicine course and contributed to ensuring course compliance with QAA requirements
  • 2010-2011: Led a task group that reviewed and improved the teaching and assessment of practical research professional skills in the MSc in Molecular Medicine.
  • 2011-2012: Development and management of a new Faculty-wide training programme in Ethics and Integrity for post-graduate research students (in collaboration with Dr. P. Vivekananda-Schmidt).

Professional Recognition and Awards

2010 - University Senate Award for Excellence in Learning and Teaching (Collaboration category)

Key Publications

  1. Guesdon F, Kaabi Y, Riley AH, Wilkinson IR, Gray C, James DC, Artymiuk PJ, Sayers JR and Ross RJ. 2012. Expression of a glycosylphosphatidylinositol anchored ligand, growth hormone, blocks receptor signalling. Biosci. Rep. 32:653-660.
  2. Greetham D, Ellis CD, Mewar D, Fearon U, an Ultaigh SN, Veale DJ, Guesdon F, and Wilson AG. 2007. Functional characterization of NF-kappaB inhibitor-like protein 1 (NFkappaBIL1), a candidate susceptibility gene for rheumatoid arthritis. Hum Mol Genet 16(24):3027-36.
  3. Ross K, Yang L, Dower S, Volpe F, and Guesdon F. 2002. Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase. J Biol Chem 277(40):37414-21.
  4. Dempsey CE, Sakurai H, Sugita T, and Guesdon F, 2000. Alternative splicing and gene structure of the transforming growth factor beta-activated kinase 1. Biochim Biophys Acta. 1517(1):46-52.
  5. Guesdon, F, Knight CG, Rawlinson L and Saklatvala J. 1997. Dual specificity of the interleukin 1- and tumor necrosis factor- activated ß casein kinase. J. Biol. Chem. 272:30017-30024.
  6. Freshney NW, Rawlinson L, Guesdon, F, Jones E, Cowley S, Hsuan J, and Saklatvala J. 1994. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell 78(60):1039-49.