Dr David Buttle BSc PhD

Reader in Matrix Biology

Academic Unit of Immunology and Infectious Diseases
Department of Infection and Immunity
K Floor
The University of Sheffield Medical School
Beech Hill Road
S10 2RX
United Kingdom

Tel: +44 (0)114 271 3164
Email: d.j.buttle@sheffield.ac.uk
Fax: +44 (0)114 271 3892
Secretary - Paula Blackwell
Tel: +44 (0)114 226 1426
Email: paula.blackwell@sheffield.ac.uk


I began my career as a Research Fellow at Shriners Burns Institute & Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, U.S.A. in 1978. From 1982 I held research posts in the Department of Biochemistry, Strangeways Research Laboratory, following which I became a post-doctoral Research Fellow with the Arthritis & Rheumatism Council. In 1993 I was appointed to a Senior Lecturer post at The University of Sheffield Medical School then as Reader in Matrix Biology in 2000.

Research Interests

My major interest is in proteolytic enzymes and extracellular matrix turnover, with principal funding from Arthritis Research UK, The Wellcome Trust and the Dunhill Medical Trust.

Professional Activities

I am a member of the following Learned Societies:

  • The Biochemical Society
  • British Society for Matrix Biology (formerly British Connective Tissue Society)
  • International Proteolysis Society (formerly International Committee on Proteolysis)

Current Projects

  • Glycosaminoglycans as modifiers of protein localisation and function
  • Developing new aids for cartilage regeneration
  • Proteoglycans – Functions and Turnover
  • Developing plant cysteine proteinases as anthelmintics
  • ADAMTS proteinases in cancer progression


For Key Publications see below.  For full list of publications click here.

Journal articles