The University of Sheffield
Department of Infection and Immunity

Dr David Buttle BSc PhD

Reader in Matrix Biology

Academic Unit of Rheumatology
Department of Infection and Immunity
K Floor
The University of Sheffield Medical School
Beech Hill Road
S10 2RX
United Kingdom

Tel: +44 (0)114 271 3164
Fax: +44 (0)114 271 3892
Secretary - Paula Blackwell
Tel: +44 (0)114 226 1426


I began my career as a Research Fellow at Shriners Burns Institute & Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, U.S.A. in 1978. From 1982 I held research posts in the Department of Biochemistry, Strangeways Research Laboratory, following which I became a post-doctoral Research Fellow with the Arthritis & Rheumatism Council. In 1993 I was appointed to a Senior Lecturer post at The University of Sheffield Medical School then as Reader in Matrix Biology in 2000.

Research Interests

My major interest is in proteolytic enzymes and extracellular matrix turnover, with principal funding from Arthritis Research UK, The Wellcome Trust and the Dunhill Medical Trust.

Professional Activities

I am a member of the following Learned Societies:

Current Projects


For Key Publications see below.  For full list of publications click here.

Journal articles