Professor Mark Wilkinson MB ChB PhD FRCS (Trauma & Orthopaedics)

Academic Unit of Bone Metabolism
Sorby Wing
Northern General Hospital
Herries Road
Sheffield
S5 7AU

Tel: 0114 2714705
Fax: 0114 2618775
Email: j.m.wilkinson@sheffield.ac.uk

Cavendish Hip Fellow

Career History

1991 MBChB University of Sheffield
1991-1996 Basic Surgical Training, Royal Hallamshire Hospital, Sheffield
1996 FRCS Royal College of Surgeons (Eng)
1996-2006 Higher Surgical Training North Trent HST Program
2002 PhD University of Sheffield
2004 FRCS (Ortho) Royal College of Surgeons (Eng)
2006 Consultant Orthopaedic Surgeon, Stockport
2007 HEFCE Clinical Senior Lecturer, University of Sheffield
2007 Honorary Consultant in Orthopaedics, Sheffield Teaching Hospitals
2012 Professor of Orthopaedics, University of Sheffield

Funding

National Institutes of Health Research
Arthritis Research UK
Clinical Research Fellow (Jan 2000 – Oct 2001)
John Charnley Trust
Clinical Research Fellow (Jan 1999 – Dec 1999)
Royal College of Surgeons of England
Laming-Evans Clinical Research Fellow (Jan 1998 – Dec1998)

Advanced Clinical Training Fellowships:
2006 Cavendish Hip Fellow, Northern General Hospital, Sheffield
2005 International Arthroplasty Fellow, Wrightington Hospital, Wigan, Lancs
2005 Zurich, Switzerland (arthroplasty)
2005 Toronto, Canada (revision arthroplasty)
2003 Multiple centres Japan, (rheumatoid surgery)

Research

Joint arthroplasty mechanisms of failure
Cytokine genetics
Metabolic bone disease
Novel biological therapies for osteolysis
Surrogate outcome markers for implant performance and failure
Clinical outcomes measurement after THA
Genetics of bone shape and remodelling responses to disease
Genetics of osteoarthritis
Effects of metal ion exposure on bone and other organ systems

Principal Funding Sources

Arthritis Research Campaign
Royal College of Surgeons of England
Cavendish Foundation
John Charnley Trust
Industry

Representative Publications

1.   arcOGEN Consortium and arcOGEN collaborators. Identification of new susceptibility loci for osteoarthritis
      (arcOGEN): a genome-wide association study. Lancet 2012; 380 (9844): 815-823.

2.   C. Lindner, et al. Short-term variability of proximal femur shape in anteroposterior pelvic radiographs. Proc 
      15th Conf Med Image Understanding and Analysis, London, U.K. BMVA Press, pages 69-73, 2011

3.   N Nicolaou, et al. The Sheffield Telescopic Intramedullary Rod System in Management of Osteogenesis
      Imperfecta -Clinical Outcomes at Average Follow up of 19 Years. J Bone Joint Surg 2011; 93-A: 1994-2000.

4.   R Andrews, et al. Effects of Cobalt and Chromium Ions at Clinically Equivalent Concentrations after Metal-
      on-Metal Hip Replacement on Human Osteoblasts and Osteoclasts: Implications for Skeletal Health. Bone
      2011; 49: 717-723

5.   AG Day-Williams, et al. A variant in MCF2L is associated with osteoarthritis Am J Hum Genet 2011; 89:
      446-450.

6.   K. Panoutsopoulou, et al. Insights into the genetic architecture of osteoarthritis: interim analysis of the
      arcOGEN study. Ann Rheum Dis 2011; 70: 864-867.

7.   HJM Kerkhof, et al. Recommendations for standardization and phenotype definitions in genetic studies of
      osteoarthritis: the TREAT-OA consortium. Osteoarthritis and Cartilage 2011; 19: 254-264.

8.   L Southam, et al. The effect of genome-wide association scan quality control on imputation outcome for
      common variants. European Journal of Human Genetics 2011; 1-5.

9.   Evangelou V, et al. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee
      osteoarthritis on chromosome 7q22. Ann Rheum Dis 2011; 70: 349-355.

10. Emms N, et al. Long term outcome of a cementless, hemispheric, press-fit acetabular component:
      Survivorship analysis and dose-response relationship to polyethylene wear. J Bone Joint Surg 2010; 92-B:
      856-861.

11. Gordon A, et al. Individual Susceptibility to Periprosthetic Osteolysis is Associated with Altered Patterns of
      Innate Immune Gene Expression in Response to Pro-inflammatory Stimuli. J Orthop Res 2010; 28: 1127-1135

12. Wilkinson JM, et al.  Polyethylene wear and osteolysis: Critical threshold versus
      continuous dose-response relationship. J Orthop Res 2005; 23 (3): 520-525

13. Wilkinson JM, et al.  Effect of pamidronate on bone
      turnover and implant migration after total hip arthroplasty: A randomized trial. J Orthop Res 2005; 23 (1):
      1-8

14. Wilkinson JM, et al.  Variation in the TNF gene promoter and risk of osteolysis after total hip arthroplasty. J
      Bone Miner Res 2003; 18 (11): 1995-2001