Dr Ishtiaq Rehman BSc, MSc, PhD
Academic Unit of Bone Biology
The Medical School
The University of Sheffield
Beech Hill Rd
Sheffield
S10 2RX
Tel: +44 (0)114 2265657
Fax: +44 (0)114 2711711
email: i.rehman@sheffield.ac.uk
Biography
I obtained a BSc (Hons) degree in Biomedical Sciences from the University of Bradford in 1992. I then obtained an MSc in Medical Biotechnology in 1993 and a PhD in 1996, both from the University of Newcastle upon-Tyne. I subsequently worked as a Postdoctoral Research Associate at the National Cancer Institute, Bethesda (USA), the Molecular Medicine Unit, University of Leeds and the Institute for Cancer Studies, University of Sheffield. After completing the Certificate in Teaching and Learning at the University of Sheffield, I was appointed as a Lecturer in Uro-oncology in the Academic Urology Unit in 2003. I joined the Department of Human Metabolism in 2008.
Research Interests
My research interests are in prostate cancer and how this leads to metastatic disease of the skeleton. Prostate cancer is the second most common cancer diagnosis and the third most common cause of cancer related deaths in men, with the majority of deaths being due to metastases in bone. The focus of my research has been to identify the proteins and pathways that are dysregulated during the metastatic progression of prostate cancer using state of the art proteomic technologies, such as iTRAQ.
Recently, we investigated the protein profiles of isogenic panels of human prostate cancer cells, which differ in their growth and metastatic potentials, to uncover a number of candidates involved in progression. In another related study we have analysed serum samples from patients both with and without metastatic disease, to identify panels of biomarkers associated with disease progression. These projects were done in collaboration with Prof. Phillip Wright (University of Sheffield), and Prof. Freddie Hamdy (University of Oxford). Selected candidates are currently being evaluated both functionally and clinically as candidate prostate cancer biomarkers, using large cohorts of patient samples.
In collaboration with Dr. Colby Eaton and Professor Peter Croucher, improved in vivo models are being developed which will facilitate studies into the early mechanisms of prostate cancer metastasis to bone, and to characterize the 'pre-metastatic' changes affecting bones prior to the metastasis of prostate cancer cells.
My work has won a number of prizes, including `Winner of the best poster prize´ at the Pathology Society of Great Britain and Ireland held in Newcastle upon-Tyne (June 2005), and `Winner of best oncology poster prize´, and the `Best Presentation in Session´ at the European Association of Urology (EAU) congress in Vienna (March 2004).
Teaching
I am both module coordinator and lecturer for the Molecular Nutrition module, which is part of the Masters/Postgraduate Diploma course in Human Nutrition. I also lecture on the MSc course in Molecular Medicine and am deputy co-ordinator for both the open book essays and Experimental Medicine modules. I lecture to Phase 3b students on the MBChB course during their medical sciences teaching week and I supervise SSC, B.Med.Sci, MSc and PhD students during their laboratory projects. I am also a Personal tutor to students on the MSc Molecular Medicine, MSc Human nutrition and MBChB courses.
Professional Activities
I am an Executive member of the Experimental Cancer Medicine Centre (ECMC) Network, Sheffield. Invited session chair for the European Association of Urology (EAU) meetings held in 2008 and 2011. I am a STEM (Science Teaching Engineering and Maths) ambassador for South Yorkshire.
Key Publications
Glen, A., Evans, C.A., Gan, C.S., Cross, S.S., Hamdy, F.C., Gibbins, J., Lippitt, J., Eaton, C.L., Noirel, J., Wright, P.C. and Rehman, I. (2010) Eight-plex iTRAQ analysis of variant metastatic human prostate cancer cells identifies candidate biomarkers of progression: An exploratory study. Prostate 70: 1313-1332.
Glen, A., Gan, C.S., Hamdy, F.C., Eaton, C.L., Cross, S.S., Catto, J.W., Wright, P.C. and Rehman, I. (2008) iTRAQ-facilitated proteomic analysis of human prostate cancer cells identifies proteins associated with progression. Journal of Proteome Research 7: 897-907.
Leiblich, A., Cross, S.S., Catto, J.W., Pesce, G., Hamdy, F.C. and Rehman, I. (2007) Human prostate cancer cells express neuroendocrine cell markers PGP 9.5 and chromogranin A. Prostate 67: 1761-1769.
Rehman, I., Goodarzi, A., Cross, S.S., Leiblich, A., Catto, J.W., Phillips, J.T. and Hamdy, F.C. (2007) DNA methylation and immunohistochemical analysis of the S100A4 calcium binding protein in human prostate cancer. Prostate 67: 341-347.
Leiblich, A., Cross, S.S., Catto, J.W., Phillips, J.T., Leung, H.Y., Hamdy, F.C. and Rehman, I. (2006) Lactate dehydrogenase-B is silenced by promoter hypermethylation in human prostate cancer. Oncogene 25: 2953-2960.