Dr Hany Lashen, FRCOG MD MB BCh

Clinical Senior Lecturer

Hany Lashen

Academic Unit of Reproductive
and Developmental Medicine
The Jessop Wing
Tree Root Walk
Sheffield
S10 2SF
UK

Office: JW4 09

Tel: +44 (0)114 226 8397
Fax: +44 (0)114 226 1074
Email: h.lashen@sheffield.ac.uk

Secretary: Miss Danièle Swain
Tel: +44 (0)114 2268317
Email: d.m.swain@sheffield.ac.uk

Biography

I joined the University of Sheffield in 2000 as a Clinical Senior Lecturer in Obstetrics and Gynaecology and also as a Consultant in Reproductive Medicine and Gynaecology in Sheffield Teaching Hospitals. Prior to that I had all my postgraduate training in the West midlands region where I also did a year as a Consultant in Obstetrics and Gynaecology prior to coming to Sheffield.

Research Interests

I have had a varied research interest in several aspects of reproduction including reproductive endocrinology, reproductive potential, psychological impact of reproductive failure and reproductive surgery (including endometriosis and pelvic pain).
The overarching theme of my research programme is the interaction between genetics, development and the environment on ovarian development, ovarian reserve, reproduction and the impact of energy balance especially overweight and underweight on reproductive performance (including fetal development) in women.
I have had several research projects with regard to ovarian response to simulation and protocol development in relation to the use of GnRH agonists and antagonists and poor responders, impact of anthropometry on ovarian response to controlled simulation, endocrinological metabolic, and the social and developmental aspects of polycystic ovary syndrome and hirsutism. I have been collaborating with Neurologists on the endocrinological and metabolic aspects of idiopathic intracranial hypertension.
My research interest with regard to reproductive surgery lies in the impact of hysterectomy on urinary and bowel function which he carries out in collaboration with Gastroenterologists and Urogynaecologists colleagues. A project is about to conclude with interesting results and will be taken forward based on the strength of the results.
Recently, I have formed a strong international group with colleagues from the UK and Finland to study the relationship between hyperandrogenism as a function of the interaction between development and the genome and its impact on cardiovascular risk in teenage girls. This study is ongoing. I also collaborate with colleagues from CDC, Atlanta, USA on interaction between environment and reproduction.

Teaching Interests

I contribute to the Phase 1b (GU and Endocrine) and am in charge of the Women´s Health component of the Level 3a. I regularly supervise B. Med. Sci students and have had a number of MD students.

Professional Activities

I am an associate editor of the International Scholarly Research Network (ISRN) Obstetris & Gynaecology Journal. In addition, I regularly referee papers for the Lancet, BMJ, Human Reproduction, Fertility and Sterility, Reproductive Biomedicine on Line, European Journal of Obstetrics and Gynaecology, Climacteric, and the British J of Obstetrics and Gynaecology.

I also referee grants for MRC, NIHR and Wellbeing for Women and was an examiner for the RCOG from 2002-2007. I have given seventeen invited lectures nationally and internationally and am the author of 9 book chapters in postgraduate text books. I am a member of the faculties of laparoscopic surgery course in Sheffield and the Gynae Ultrasound course in Grimsby.

Current Projects

• Efficacy of metformin in pregnant obese women, a randomised controlled trial.

• The prevalence of hyperandrogenism in teenage girls: developmental origins and association with cardiovascular risk.

• Anti-Mullerian hormone as a marker of reproductive potential and ovarian follicular growth activity.

• Relationship between maternal high body mass index and fetal growth.

• Impact of body mass index on reproductive potential of women.

• Effect of hysterectomy on bowel function.

Key publications

Kelly, C.J., Stenton, S.R., and Lashen, H. (2010) Insulin like growth factor binding protein 1 in PCOS: a systematic review and meta-analysis. Human Reproduction Update in press

Bayley, T.M., Slade, P., and Lashen, H. (2009) Relationships between attachment, appraisal, coping and adjustment in men and women experiencing infertility concerns. Human Reproduction 2827-2837.

Stevenson, T.L., and Lashen, H. (2008) Empty follicle syndrome: the reality about a controversial syndrome, a systematic review. Fertility and Sterility 90: 691-698.

Mohamed, K.A., Davies, W.A., and Lashen, H. (2007) Dynamics of pituitary down-regulation and ovarian response to controlled stimulation in in vitro fertilisation cycles. Fertility and Sterility 87: 433-435.

Mohamed, K.A., Davies, W.A., and Lashen, H. (2006) Antimullerian hormone and pituitary gland activity after prolonged down-regulation with goserelin acetate. Fertility and Sterility 86: 1515-1517.

McIlveen, M., Lok, D., Pritchard, J., and Lashen, H. (2005) Modern embryo transfer catheters and pregnancy outcome. Fertility and Sterility 84: 996-1000.

Lashen, H., Fears, K., and Sturdee, D. (2004) Obesity is associated with increased risk of early and recurrent miscarriage: matched case control study. Human Reproduction 19: 1644-1646.

Lashen, H., Ledger, W., Bernal, A., and Barlow, D. (1999) Extremes of body mass index do not adversely affect the outcome of superovulation and in vitro fertilisation. Human Reproduction 14: 712-715.