Dr Alison Gartland, BSc (Hons), PhD
Reader in Bone and Cancer Biology
Academic Unit of Bone Biology
Department of Oncology & Metabolism
University of Sheffield Medical School
Beech Hill Road
Tel: (+44) 0114 215 9046
Fax: (+44) 0114 271 2475
Secretary - Laura Phelan: (+44) 0114 215 9019
I studied Biomedical technology at Sheffield Hallam University and following a period in Industry studied for my PhD at The University of Liverpool in Prof Jim Gallagher´s lab on the "Expression and functional significance of the P2X7 receptor in skeletal tissue." I then moved to Montpellier, France where I was a Post-Doctoral Researcher at IGMM, CNRS in Bob Hipskind´s lab. Following this I was a Senior Post-Doctoral Researcher in Department of Cell Biology at University of Massachusetts Medical School USA in the late Prof Sandy Marks Jnr´s lab.I joined the University of Sheffield in 2006 as a lecturer in Bone Biology.
My research interests are in P2 receptor signalling in musculoskeletal disease and cancer. The role of P2 purinoreceptor ligands (ATP and other nucleotides) as extracellular messengers is well established and there is now conclusive evidence, from my previous work and that of others, that extracellular nucleotides have a highly influential role in the bone microenvironment.In addition to their roles in bone, nucleotides have been shown to play a role in cancer and synergise with growth factors to stimulate c-fos gene expression, cell proliferation and neoplastic progression.
I lecture on the undergraduate Medical Course, the MSc inMolecular Medicine course and I am lead for the B.Med.Sci. Ethics module. I also run the Doctoral Development Programme module"Effective Presentation and Seminar Participation" MED605. I am Chair of the Medical School Graduate Committee, Director of Undergraduate Research Teaching and Deputy Director of the BMedSci Programme.
I am the Secretary of the Bone Research Society, Founder and Secretary of the UK Purine Club, and member of the European Calcified Tissue Society, the International Bone and Mineral Society and the American Society for Bone and Mineral Research.
• Investigating the role of purinergic signalling in bone formation and homeostasis.
• The mechanisms of ATP release from osteoblasts.
• Association of polymorphisms in the P2X7 receptor with osteoporosis and arthritis-induced joint destruction and bone loss.
• The effect of metal ions on bone cell activity in vitro.
• Signalling pathways synergistically activated by P2 and growth factor receptors in osteosarcoma and breast cancer cells.
• The role of P2X receptors in osteoclastogenesis and function