Dr. Craig Murdoch (BSc, PhD)

Non-Clinical Lecturer in Oral Science

Tel:     +44 (0) 114 226 5458
Fax:    +44 (0) 114 271 7863
Email:  c.murdoch@sheffield.ac.uk

Research Interests

The role of leukocytes, chemokines and adhesion molecules in tumour development, progression and metastasis
Interaction of bacteria and fungi with endothelial and epithelial cells
Innate immune responses to infection

Recently Published Papers

Webb, SD., Owen, MR., Byrne HM, Murdoch C, Lewis CE, (2007) Macrophage-based anticancer therapy: modelling different modes of tumour targeting. Bull Math Biol (in press)

Faber,J., Meyer,C.U., Gemmer, M.D., Russo,A., Finn,A., Murdoch,C., Zenz,W., Mannhalter,C., Zabel,B.U., Schmitt,H-J., Habermehl,P., Zepp,F., and Knuf,M. (2006) Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy. Ped Infect Dis J 25(1):80-81.

Murdoch,C., Muthana,M., and Lewis,C.E. (2005) Hypoxia regulates macrophage functions in inflammation. J Immunol 175:6257-6263.

Murdoch,C. and Lewis,C.E. (2005) Macrophage migration and gene expression in response to tumor hypoxia. Int J Cancer 117:701-708.

Lewis,C. and Murdoch,C. (2005) Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am J Pathol 167:627-635.

Murdoch,C., Giannoudis,A., and Lewis,C.E. (2004) Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 104:2224-2234.

Zhang,Q.B., Arnaoutakis,K., Murdoch,C., Lakshman,R., Race,G., Burkinshaw,R., and Finn,A. (2004) Mucosal immune responses to capsular pneumococcal polysaccharides in immunized preschool children and controls with similar nasal pneumococcal colonization rates. Ped Infect Dis J 23:307-313.

Lakshman,R., Murdoch,C., Race,G., Burkinshaw,R., Shaw,L., and Finn,A. (2003) Pneumococcal nasopharyngeal carriage in children following heptavalent pneumococcal conjugate vaccination in infancy. Arch Dis Child 88:211-214.

Murdoch,C., Read,R.C., Zhang,Q., and Finn,A. (2002) Choline-Binding Protein A of Streptococcus pneumoniae elicits chemokine production and expression of Intercellular Adhesion Molecule 1 (CD54) by human alveolar epithelial cells. J Infect Dis 186:1253-1260.

Murdoch,C. and Finn,A. 2000. Chemokine receptors and their role in inflammation and infectious diseases. Blood 95:3032-3043.

Prest,S.J., Rees,R.C., Murdoch,C., Marshall,J.F., Cooper,P.A., Bibby,M., Li,G., and Ali,S.A. (1999) Chemokines induce the cellular migration of MCF-7 human breast carcinoma cells: subpopulations of tumour cells display positive and negative chemotaxis and differential in vivo growth potentials. Clin Exp Metastasis 17:389-396.

Murdoch,C., Monk,P.N., and Finn,A. (1999) Functional expression of chemokine receptor CXCR4 on human epithelial cells. Immunology 98:36-41.

Murdoch,C., Monk,P.N., and Finn,A. (1999) CXC chemokine receptor expression on human endothelial cells. Cytokine 11:704-712.

Current MPhil/PhD students

Simon Tazzyman - The role of neutrophils and their related chemokines in tumour angiogenesis and progression

Mona Larsen - The role of Macrophage Migration Inhibitory Factor in tumour development

Hsin-Yu Fang - Regulation of gene expression in macrophages by tumour hypoxia: the role of hypoxia-induced transcription factors

Semih Dogan – Chemokine induction by pneumococcal proteins in nasopharyngeal epithelial cells

Personal Web Link

Cell interactions in oral disease