Professor Ian M. Brook BDS FDSRCS MDS PhD
Professor of Oral Surgery and Oral Medicine
OMMS,
The Clinical School of Dentistry,
Claremont Crescent,
Sheffield
S10 2TA
Telephone +44 [0] 114 2717851 or 7849
email : i.brook@sheffield.ac.uk
Biography
Professor Brook graduated with a dental degree from the University of Liverpool in 1978. Hospital posts in Liverpool, London (The Middlesex and St. Bartholomew´s), Truro and Aberdeen followed. Appointed to the University of Sheffield in 1983 he gained his MDS in 1986 for `In vitro studies into the development of intra-oral inserts for the controlled delivery of drugs´, and PhD in 1994 for studies into the biocompatibility of Glass-ionomer cements.
With Professors Ric van Noort and Paul Hatton Professor Brook leads an internationally recognised biomaterials/tissue engineering group undertaking fundamental and applied studies into the biological response induced by implanted materials and the nature of the biomaterial/tissue interface. The group has particular expertise in the field of ionomeric materials, ceramics, and surface modification of biomaterials and tissue engineering of mucosa, cartilage and bone. Major funding for this work has been received from the EU since 1992.
In the clinical field Professor Brook´s interests lie in the field of dental Implantology and in maintaining standards.
Professor Brook has published over 90 papers and 180 scientific abstracts.
Administrative Role
Clinical Director Charles Clifford Dental Hospital and School of Clinical Dentistry.
Director of Clinical Studies School of Clinical Dentistry
Member Clinical Management Board Sheffield Teaching Hospitals NHS F Trust
National Administrative Role
Maintaining clinical standards – CGD conduct committees, NHS litigation authority and work for Dental indemnity societies.
Research Interests
Tissue Engineering, Biomaterials, Dental Implants
Current Research Projects:
- Studies into the air/tissue/implant interface using tissue engineered oral mucosa.
- Evaluation of Dental Materials and Therapeutic agents applied to oral mucosa/teeth.
- Biocompatibility of novel bioactive glasses and ceramics for bone augmentation.
- Drug trials using –wisdom tooth – pain model.
Recently Published Papers
K. Moharamzadeh, I. Brook, A. Scutt, M. Thornhill, R. Van Noort `Mucotoxicity of dental composite resins on a tissue-engineered human oral mucosal model´ .Journal of Dentistry ,Volume 36 ,Issue 5, Pages 331 - 336 (2008)
Keith A. Blackwood, Rob McKean, Irene Canton, Christine O. Freeman, Kirsty L. Franklin, Daryl Cole, Ian Brook, Paula Farthing, Stephen Rimmer, John W. Haycock, Anthony J. Ryan and Sheila McNeil
Development of biodegradable electrospun scaffolds for dermal replacement Biomaterials Volume 29, Issue 21, Pages 3091-3104 (2008)
I Cantón, R McKean, D Cole ,K Blackwood, C Freeman, K Franklin, P Farthing, I Brook, J W Haycock , A J. Ryan, S MacNeil `Development of a synthetic matrix to replace human dermis´ European Cells and Materials Vol. 16. Suppl. 3, Page 4 (2008) ISSN 1473-2262
Naruporn Kanchanarat, Sanchita Bandyopadhyay-Ghosh, Ian M.Reaney, Ian M.Brook2 and Paul V. Hatton2 "Microstructure and mechanical properties of fluorcanasite glass-ceramics for biomedical applications." Journal of Materials Science, 43(2) 759-765 (2008)
D.Boyd, G.Carroll, M.R.Towler, C.Freeman, P.Farthing and I.M.Brook. `Preliminary investigation of novel bone graft substitutes based on strontium–calcium–zinc–silicate glasses´ Journal of Materials Science: Materials in Medicine 20: 413-420 (2009)
Keyvan Moharamzadeh, Kirsty L Franklin, Ian M Brook, Richard van Noort. `Biological assessment of antiseptic mouthwashes using a 3D human oral mucosal model´ Journal of Periodontology May; 80(5):769-75 (2009)
Keyvan Moharamzadeh, Ian M. Brook and Richard Van Noort `Biocompatibility of Resin-based Dental Materials´ Materials 2, 541-548 (2009)
S. Bandyopadhyay-Ghosh, P. E. P. Faria, A. Johnson, D. N. B. Felipucci, L. A. Salata, I. M. Reaney, I. M. Brook and P. V. Hatton, "Osteoconductivity of modified fluorcanasite glass-ceramics for bone tissue augmentation and repair´, Journal of Biomedical research Vol 98A issue 3, 760-768 (2010) Published Online: Mar 24 2010 1:57PM DOI: 10.1002/jbm.a.32750
Wen- Lin Chai, Keyvan Moharamzadeh, Ian M. Brook, Lena Emanuelsson, Anders Palmquisit, Richard VanNoort . Development of a novel model for the investigation of implant-soft tissue interface Journal of Periodontology Aug; 81(8):1187-95 (2010)
Wen Lin Chai,; K Moharamzadeh, I Brook, R VanNoort, "A Review Of The Histomorphometric Analysis Techniques For The Assessment Of Implant-Soft Tissue Interface" Biotechnic & Histochemistry. (2010) Apr 14. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/20392135
Shashwat Bhakta • Deepak K. Pattanayak • Hiroaki Takadama •Tadashi Kokubo • Cheryl A. Miller • Mehdi Mirsaneh • Ian M. Reaney •Ian Brook • Richard van Noort • Paul V. HattonPrediction of osteoconductive activity of modified potassiumfluorrichterite glass-ceramics by immersion in simulated body fluid J Mater.Sci. Materials in Medicine. Published online 20 Aug 2010 DOI 10.1007/s10856-010-4145-y
Research Students
4 in the field of biomaterials/tissue engineering
Personal Web Links
Research
Dental Implants