Professor Cameron McLeod

Prof Cameron McLeod

Phone: 0114 22 23602
Room Number: B11b

email : c.w.mcleod@sheffield.ac.uk

Professor: B.Sc. Edinburgh (1973), Ph.D. Imperial College, London (1977); Research Fellowship, National Institute for Environmental Studies, Japan (1997-1980); Lecturer/Senior Lecturer/Reader, Sheffield Hallam University (1981-1995). Director, Centre for Analytical Sciences - CASAtomic.co.uk. CChem, FRSC, FRSM.

CASAtomic

Key Words

Mass spectrometry. Laser ablation and ICP spectrochemical analysis. Chemical speciation. Trace/environmental/bio/materials characterisation.

Research Interests

Research concerns the development and initiation of novel and highly sensitive techniques for trace determination/element speciation in key areas of chemical analysis. Sample introduction/presentation and on-line reaction chemistry are key themes. Microcolumn flow injection systems provide a new route for enhancing performance in ICP emission and mass spectrometry, a particular success being the capability to speciate and determine toxic trace elements in environmental systems. Laser ablation is becoming an increasingly important analytical tool for spatial and depth profiling studies in addition to providing bulk analysis data. Research in progress includes new measurement strategies for strategic materials, (thin films, polymers, clean steels) and for interrogating tree bark pockets to assess past historical data (chemical pollution). In the context of metallodrug therapy laser ablation is being developed as an interface between gel electrophoresis and ICP mass spectrometry to characterise metal protein systems. Most recent research concerns the use of labelled antibodies for bioimaging.

Selected Publications

  • Mapping aerial deposition in metropolitan areas from tree bark: A case study in Sheffield, England. E. Schelle, B.G. Rawlins, R.M. Lark, R. Webster, I. Staton, C.W. McLeod. Environmental Pollution. (on line, 2007).

  • Combination of gel electrophoresis and ICP-Mass Spectrometry – novel strategies for phosphoprotein measurement. V.L. Elliott, C.W. McLeod, P.S. Marshall, Anal; & Bioanal. Chem., 383, 416-423, 2005.

  • Imaging and spatial distribution of beta-amyloid peptide and metal ions in Alzheimer’s plaques by Laser Ablation Inductively Coupled Plasma-Mass Spectrometry. R. Hutchinson, A.G. Cox, C.W. McLeod, P.S. Marshall, A. Harper, E.L. Dawson, D.R. Howlett. Anal. Biochem., 346, 225-233, 2005.

  • Characterisation of inclusions in clean steels via Laser Ablation-ICP Mass Spectrometry. C. Dubuisson, A.G. Cox, C.W. McLeod, I. Whiteside, R. Jowitt, H. Falk. Iron and Steel Institute of Japan International, 44(11), 1859-1866, 2004.

  • Speciation of protein-bound trace elements by gel electrophoresis and atomic spectrometry. R. Ma, C.W. McLeod, K. Tomlinson, R.K. Poole. Electrophoresis, 25, 2469-2477, 2004.

  • Detection and characterisation of Zn and Cd binding proteins in E.coli by gel electrophoresis and Laser Ablation-ICP-Mass Spectrometry. M. Binet, R. Ma, C.W. McLeod, R. Poole. Anal. Biochem., 1, 318/1, 30-38, 2003.

See also