Graham LeggettProf. Graham J. Leggett

Professor of Nanoscale Analytical Science

Room: E17

Tel: +44-(0)114-22-29556

Fax: +44-(0)114-22-29436




Biographical Sketch

Prof. Leggett obtained a BSc in Chemistry from UMIST in 1987. His PhD from the same institution, obtained in 1990, was followed by consecutive appointments as Research Associate at Universities of Washington and Nottingham. In 1994 he was appointed as lecturer at the University of Nottingham 1994-98. He became a Lecturer at UMIST in 1998, where he was subsequently promoted to senior lecturer and reader. In 2002 he was appointed as Professor of nanoscale analytical chemistry at the University of Sheffield.

Research Keywords

Analytical Science, Scanning Probe Microscopy, Near-Field Optics, Nanofabrication, Biomaterials, Surface Chemistry.

Teaching Keywords

Analytical Chemistry; Surface Chemistry

Selected Publications:

  • Fabrication of Self-Cleaning, Reusable Titania Templates for Nanometer and Micrometer Scale Protein Patterning. M. Moxey, A. Johnson, O. El-Zubir, M. Cartron, S. S. Dinachali, C. N. Hunter, M. S. M. Saifullah, K. S. L. Chong, G. J. Leggett. ACS Nano 2015, 9(6), 6262-6270.
  • Fast, Simple, Combinatorial Routes to the Fabrication of Reusable, Plasmonically Active Gold Nanostructures by Interferometric Lithography of Self-Assembled Monolayers. A. Tsargorodska, O. El Zubir, B. Darroch, M. I. L. Cartron, T. Basova, C. N. Hunter, A. V. Nabok, G. J. Leggett. ACS Nano 2014, 8(8), 7858-7869.
  • Zwitterionic Poly(amino acid methacrylate) Brushes. A. M. Alswieleh, N. Cheng. I. Canton, B. Ustbas, X. Xue, V. Ladmiral, S. Xia, R. E. Ducker, O. El Zubir, M. L. Cartron, C. N. Hunter, G. J. Leggett, S. P. Armes. Journal of the American chemical Society, 2014, 136(26), 9404-9413
  • Photocatalytic Nanolithography of Self-Assembled Monolayers and Proteins. E. Ul-Haq, S. Patole, M. Moxey, E. Amstad, C. Vasiley, C. N. Hunter, G. J. Leggett, N. D. Spencer, N. H. Williams, ACS Nano 2013, 7(9), 7610-7618.
  • Protein Micro- and Nanopatterning Using Aminosilanes with Protein-Resistant Photolabile Protecting Groups. S. A. Alang Ahmad, L. S. Wong, E. Ul-Haq, J. K. Hobbs, G. J. Leggett, J. Micklefield. Journal of the American Chemical Society 2011,133(8), 2749-2759.
  • Light-directed nanosynthesis: near-field optical approaches to integration of the top-down and bottom-up fabrication paradigms. G. J. Leggett, Nanoscale 2012, 4(6), 1840-1855.
  • Relationship Between Molecular Contact Thermodynamics and Surface Contact Mechanics. N. Nikogeorgos, C. A. Hunter, G. J. Leggett. Langmuir 2012, 28(51), 17709-17717
  • Parallel Scanning Near-Field Photolithography: The Snomipede.E. U. Haq, Y. Zhang, S. A. A. Ahmad, L. S. Wong, S. P. Armes, J. K. Hobbs, G. J. Leggett, J. Micklefield, C. J. Roberts, J. M. R. Weaver. Nano Lett. 2010, 10, 4375-4380.
  • Site-Specific Immobilization and Micrometer and Nanometer Scale Photopatterning of Yellow Flourescent Protein on Glass Surfaces. N. P. Reynolds, J. D. Tucker, P. A. Davison, J. A. Timney, C. N. Hunter, G. J. Legett J. Am. Chem. Soc. 2009, 131(3), 896-897
  • Matching the Resolution of Electron Beam Lithography by Scanning Near-Fiedl Photolithography.  S. Sun, G. J. Leggett. Nano Lett. 2004, 4, 1381-1384


Research Graham Leggett

Research Interests

Scanning probe microscopy (SPM) has revolutionised our ability to characterise the surface morphologies of complex and difficult materials. However, much more exciting and potentially more powerful are the capabilities that SPM techniques provide for the measurement of surface properties and for the manipulation of molecular structure. Our work focuses on the development of quantitative measurement tools for the investigation of molecular and polymeric surfaces (for example, the development of friction and chemical force microscopies for studying nanometre scale tribological phenomena).

Besides offering tools for surface characterisation, scanning probe instruments provide powerful capabilities for the modification of surface molecular structure. We have developed a new technique, scanning near-field photolithography, in which a scanning near-field optical microscope is used to fabricate structures that may be as small as 9 nm, using photochemical reactions. Our goal is to integrate top-down (lithographic) methods with bottom-up (synthetic) techniques by exploiting the versatility of photochemical methods as tools for executing very specific molecular transformations, in combination with the exquisite spatial resolution accessible in the near field. A particular emphasis of our work is the development of methods for the fabrication of biological nanostructures for use in novel highly miniaturised, high sensitivity analytical systems.

Teaching Section

Physical Chemistry

Undergraduate Courses Taught

  • Fuel (Year 1)
  • The aim of this segment is to explore how chemical principles may be used to make qualitative assessments of the efficiency of energy production by a variety of means, and to explore the complexity of many of the issues that currently face society as it grapples with the problems of climate change and energy supply scarcity.
  • UV-visible and magnetic resonance spectroscopy (Year 2)
    The aims of this segment are to introduce general principles that apply to spectroscopic analysis, and to describe in more detail the use of UV-visible spectroscopy and magnetic resonance spectroscopy in molecular structure determination. Emphasis is placed on understanding the basic physical principles underpinning the techniques. 
  • Solid Surfaces and Catalysis (Year 3)
    This course considers the nature of gas-solid interactions and their relationship to catalytic activity.
  • Nanochemistry (Year 4)
    Provide an overview of the role of chemistry in nanotechnology, and introduce students to major techniques for the fabrication and characterisation of nanostructured materials and devices.

Postgraduate Courses Taught

  • CHM6201: Polymer characterisation and Analysis C

Tutorial & Workshop Support

  • First Year Workshops.
  • Second Year Physical Chemistry Tutorials.
  • Second Year Workshops.
  • Third Year Workshops.
  • Third Year Literature Review.
  • Fourth Year Workshops.

Laboratory Teaching

  • Second Year Laboratory Demonstrating
  • Third Year Advanced Physical Chemistry
  • Fourth Year Research Project.

Journal articles


Conference proceedings papers

  • Moxey M, El Zubir O, Johnson A, Dinachali SS, Saifullah MSM, Chong KSL & Leggett GJ (2014) Self-cleaning, reusable templates for protein nanopatterning fabricated by interferometric lithography and nanoimprinting. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 248
  • Leggett GJ, Alswieleh A, Cheng N, Canton I, Ustbas B, Xue X, Ladmiral V, Xia S, Ducker RE, El Zubir O, Cartron ML, Hunter CN & Armes SP (2014) Synthesis and nanometer-scale patterning of stimulus-responsive, biofouling-resistant zwitterionic poly(amino acid methacrylate) brushes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 248
  • Ducker RE, El Zubir O, Wang L, Cartron ML, Mullin N, Cadby A, Hobbs J, Hunter CN & Leggett GJ (2014) Nanoscale positioning of multiple proteins by scanning near-field photolithography. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 248
  • Tsargorodska A, El Zubir O, Johnson A & Leggett GJ (2014) Fabrication of metal nanostructures over macroscopic areas by interferometric lithography of self-assembled monolayers. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 247
  • Nikogeorgos N, Hunter CA & Leggett GJ (2012) Mechanics and thermodynamics of nanometre-scale molecular contacts. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 244
  • Leggett G (2012) Continuous wave cavity ring-down spectroscopy for environmental applications. Optical Instrumentation for Energy and Environmental Applications, E2 2012
  • Ducker RE, Montague MT, Sun S & Leggett GJ (2007) Fabrication of sub-diffraction-limit molecular structures by scanning near-field photolithography - art. no. 664513. Nanoengineering: Fabrication, Properties, Optics, and Devices IV, Vol. 6645 (pp 64513-64513)
  • Leggett GJ, Chong KSL & Sun SQ (2004) Scanning near-field photolithography: A new tool for fabricating molecular nanostructures.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 227 (pp U875-U875)
  • Chong KSL, Sun S & Leggett GJ (2004) Scanning near-field photolithography: A new route to biological nanostructures. Transactions - 7th World Biomaterials Congress (pp 1368)
  • Hobbs JK, Winkel AK, McMaster TJ, Humphris ADL, Baker AA, Blakely S, Aissaoui M & Miles MJ (2001) Some recent developments in SPM of crystalline polymers. Macromolecular Symposia, Vol. 167(1) (pp 1-14)
  • Leggett GJ, Beake BD & Brewer NJ (2000) Scanning force microscopy of polyester: surface structure and adhesive properties. American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, Vol. 41(2) (pp 1435-1436)
  • Leggett GJ & Beake BD (1998) Development of surface morphology, local friction and adhesion in plasma-treated poly(ethylene terephthalate) films. American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, Vol. 39(2) (pp 1228-1229)
  • Scotchford CA, Sim B, Hutt D, Leggett G & Downes S (1996) Surface energy effects on osteoblast attachment: A model system. Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium, Vol. 1 (pp 597)