The University of Sheffield
Chemical and Biological Engineering

Dr Robert FalconerDr Robert Falconer

BSc PhD

Senior Lecturer

Tel: +44 (0)114 222 8253
Fax: +44 (0)114 222 7501

Email: r.j.falconer@sheffield.ac.uk

Chemical and Biological Engineering
The University of Sheffield
Sir Robert Hadfield Building
Sheffield
S1 3JD

Teaching

Course Director for MSc Biological and Bioprocess Engineering

Research Interests

  • Protein stability and formulation
  • Interaction between proteins, water and small molecules
  • Spectroscopy technology especially Terahertz time domain and far-infrared spectroscopy
  • Micro-calorimetry
  • Beverage manufacturing

Courses taught

CPE1004 Science for Chemical Engineers
CPE3001 Practical Analysis of Biological Systems

Biography

As a postgraduate I worked at the biotechnology companies Biotech Australia and GroPep working on expression and purification of recombinant proteins, process design and quality management. I went on to graduate with a PhD in process design from the Department of Chemical Engineering at The University of Adelaide in South Australia. I returned to the business sector working in production management at Diagnostic Systems Laboratories and Tuta Healthcare (medical diagnostics and medical device manufacturers, respectively). In 2003 I accepted a position as research coordinator at the Department of Chemical Engineering at The University of Cambridge where I undertook research on protein refolding and virus-like particle self-assembly. I then worked at the Australian Institute for Bioengineering and Nanotechnology (AIBN) at the University of Queensland, undertaking research on protein stability and protein-small molecule interactions using micro-calorimetry and a range of spectroscopy techniques.

In 2011 I was appointed by the Department of Chemical & Biological Engineering at the University of Sheffield as a senior lecturer.

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I am also a founding member of the Pharmaceutical Engineering Interest Group.

Key Papers

Ding, T., Huber, T., Middelberg, A.P.J., Falconer, R.J. (2011) Characterisation of low frequency modes in aqueous peptides using far-infrared spectroscopy and molecular dynamic simulation. Journal of Physical Chemistry A, 115: 11559–11565.

Falconer, R.J., Marangon, M., van Sluyter, S.C., Neilson, K.A., Chan, C., Waters, E.J. (2010) Thermal stability of thaumatin-like protein, chitinase and invertase isolated from Sauvignon blanc and Semillon juice, and their role in haze formation in wine. Journal of Agricultural and Food Chemistry, 58: 975-980.

Ding, T., Li, R., Zeitler, J.A., Huber, T.L., Gladden, L.F., Middelberg, A.P.J., Falconer, R.J. (2010) Terahertz and far-infrared spectroscopy of alanine-rich peptides with variable ellipticity. Optics Express, 18: 27431–27444.

McRae, J.M., Falconer, R.J., Kennedy, J.A. (2010) Thermodynamics of grape and wine tannin interaction with polyproline: implications for red wine astringency. Journal of Agricultural and Food Chemistry, 58: 12510–12518.

Falconer, R.J., O’Neill, B.K., Middelberg, A.P.J., (1999) Chemical treatment of Escherichia coli: 3. Selective extraction of a recombinant protein from cytoplasmic inclusion bodies in intact cells. Biotechnology and Bioengineering, 62: 455-460.