Dr. Javaid Iqbal [MBBS, MRCP, PhD]

NIHR Clinical Lecturer in Cardiology

Address
Department of Cardiovascular Science
University of Sheffield
Medical School
Beech Hill Road
Sheffield
S10 2RX

Tel: +44 (0)114 226 8986
Fax: +44 (0)114 271 1863
Email: j.iqbal@sheffield.ac.uk

Biography:

I completed my general medical training at the Leeds Teaching Hospitals NHS Trust. In 2007, I commenced a Clinical Research Fellow post (funded by the British Heart Foundation) at the University of Edinburgh. I worked with Professor Brian Walker, Professor David Newby and Dr. Patrick Hadoke and completed my PhD by investigating role of intracellular glucocorticoid regulation in cardiovascular remodelling.

I joined University of Sheffield in 2010 to work as a Clinical Lecturer in the Department of Cardiovascular Science and as an honorary Specialist Registrar in Cardiology at the Sheffield Teaching Hospitals NHS Foundation Trust. My subspecialty interest is Interventional Cardiology.

Research Interests:

I am keen to translate research findings from experimental lab to clinical practice with the aim to eventually improve patient care and outcomes. My current projects include:

• Risk stratification in cardiovascular diseases.
• Relationship of frailty, cardiovascular diseases and outcomes.
• Intra-coronary imaging in clinical and pre-clinical studies.
• Novel therapeutic targets for reducing infarct size after heart attack.
• Effects of mineralocorticoid receptor antagonism on cardiovascular remodelling.

Teaching Interests:

• Fellow of Higher Education Academy, UK.
• Module lead for Vascular Disease and Clinical Practise (MED6052) in Cardiovascular Pathway of MSc Molecular Medicine.
• Deputy coordinator for phase-2 Cardiovascular clinical skills teaching.
• Teach cardiology to undergraduate and post-graduate medical students.
• Supervise Research Students (BMed Science, MSc, MD/PhD).

Professional Activities:

I am a member of British Cardiovascular Society, British Society of Cardiovascular Research, European Society of Cardiology and European Association of Percutaneous Coronary Interventions. I also represent local cardiology trainees at the British Junior Cardiologists Association. I am also an associate editor of EuroIntervention.

Key Publications:

1. Iqbal J, Sumaya W, Tatman V, Parviz Y, Morton AC, Grech ED, Campbell S, Storey RF, Gunn J. Incidence and predictors of stent thrombosis: a single-centre study of 5,833 consecutive patients undergoing coronary artery stenting. EuroIntervention (in press).


2. Iqbal J, Denvir MA, Gunn J. Frailty assessment as a prognostic tool in elderly people. LANCET (in press).


3. Zhang Y, Zhang X, Li M, Iqbal J, Bourantas CV, Li J, Su X, Muramatsu T, Tian N, Chen SL. The ginsenoside Rg1 prevents transverse aortic constriction induced left ventricular hypertrophy and cardiac dysfunction by inhibiting fibrosis and enhancing angiogenesis. Journal of Cardiovascular Pharmacology (in press).


4. Iqbal J, Gunn J, Serruys PW. Coronary stents: historical development, current status and future directions. British Medical Bulletin 2013 (epub ahead of print).


5. Kipari T, Hadoke PW, Iqbal J, Man TY, Miller E, Coutinho AE, Zhang Z, Sullivan KM, Mitic T, Livingstone DE, Schrecker C, Samuel K, White CI, Bouhlel MA, Chinetti-Gbaguidi G, Staels B, Andrew R, Walker BR, Savill JS, Chapman KE, Seckl JR. 11beta-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis. FASEB J 2013;27(4):1519-1531.


6. Iqbal J, Macdonald LJ, Low L, Seckl JR, Yau CW, Walker BR, Hadoke PW. Contribution of endogenous glucocorticoids and their intravascular metabolism by 11beta-hsds to postangioplasty neointimal proliferation in mice. Endocrinology 2012;153(12):5896-905.


7. Hughes KA, Manolopoulos KN, Iqbal J, Cruden NL, Stimson RH, Reynolds RM, Newby DE, Andrew R, Karpe F, Walker BR. Recycling between cortisol and cortisone in human splanchnic, subcutaneous adipose, and skeletal muscle tissues in vivo. Diabetes 2012;61(6):1357-64.


8. Gunn J, Siotia A, Malkin CJ, Iqbal J, Raina T, Morton AC. Novel use of a pericardium-covered stent graft to treat bulky coronary artery thrombus. Catheter Cardiovasc Interv 2012;80(1):59-64.


9. Fenning S, Woolcock R, Haga K, Iqbal J, Fox KA, Murray SA, Denvir MA. Identifying acute coronary syndrome patients approaching end-of-life. PLoS One 2012;7(4):e35536.


10. Iqbal J, Macdonald LJ, Yau CW, Walker BR, Hadoke PWF. YIA 3 Effect of intracellular glucocorticoid metabolism on neointimal proliferation in a mouse model of wire angioplasty. Heart 2011;97(20):e7.


11. Iqbal J, Francis L, Reid J, Murray S, Denvir M. Quality of life in patients with chronic heart failure and their carers: a 3-year follow-up study assessing hospitalization and mortality. Eur J Heart Fail 2010;12(9):1002-8.


12. Iqbal J, Fox KAA. Epidemiological trends in acute coronary syndromes: understanding the past to predict and improve the future. Arch Med Sci 2010;6(1A):S3-S14.


13. Hadoke PW, Iqbal J, Walker BR. Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease. Br J Pharmacol 2009;156(5):689-712.

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