The University of Sheffield
Department of Cardiovascular Science

Professor Iain D Wilkinson BSc, MSc, PhD, CSci, ARCP, FIPEM

Professor Iain WilkinsonDepartment of Cardiovascular Science
Academic Radiology
C Floor
Royal Hallamshire Hospital
Sheffield
S10 2JF
UK

Tel: +44 (0)114 271 2191
Fax: +44 (0)114 272 4760
Email: i.d.wilkinson@sheffield.ac.uk

Biography:

I am Professor of Magnetic Resonance (MR) Physics and lead the adult neuroimaging research programme within the Academic Unit of Radiology, part of the University´s Medical School based at the Royal Hallamshire Hospital. I particularly enjoy the clinical applications of MR and as a UK state-registered Clinical Scientist, am an honorary Consultant with local NHS Trusts.

Prior to joining the University of Sheffield in 1997, I was an NHS physicist at The Middlesex Hospital (UCLH) and Addenbrooke´s Hospital in Cambridge. I obtained my Bachelors in Physics from the University of Lancaster, Masters in Radiation Physics from St Bartholomew´s Hospital Medical College and Doctorate in MR from the Royal Postgraduate Medical School (at Hammersmith Hospital, now part of Imperial College).

Research Interests

I aim to further our understanding of neurological disease and thereby aid its diagnosis and treatment via in-vivo MR Imaging & Spectroscopy. The emphasis of this has always been on the translation of MR techniques and the findings of MR studies into clinical use. Clinical areas thus far concentrated on have included:

I'm also interested in the non-medical applications of MR particularly with respect to our understanding of the human mind.

I am indebted to the Wellcome Trust, Neurocare, Action for M.E, EAFD/Novo Nordisk, JDRF, Diabetes UK, EU, MRC, DH / NIHR, EPSRC, University of Sheffield Alumni, Ataxia UK, Sheffield Health & Social Research Consortium, Sheffield Hospital’s Charitable Trust, Leverhulme Trust, Pfizer IIR and Philips Healthcare for their financial help in support of collaborative imaging research.

Teaching Interests:

I supervise research projects for students undertaking BMedSci, MD and PhD projects. I am also an undergraduate tutor for students studying on Sheffield’s Medical Course.

Professional Activities:

In addition to being a Fellow of the Institute of Medical Physics & Engineering in Medicine (IPEM), I am currently a member of the IPEM´s MR Special Interest Group that organises scientific and educational meetings and deals with professional matters relating to the Institute´s involvement in MR Physics. I am an active member of the International Society of Magnetic Resonance in Medicine (ISMRM) and the British Chapter of the ISMRM that hold `cutting edge´ scientific meetings and symposia. I´m also a member of the British Institute of Radiology which is a forum for the multidisciplinary teams who are professionally involved or interested in medical imaging. When applying physics to medicine and clinical research, it is important to grasp an understanding what drives clinical problem solving and to link with the medical professionals involved. To this end, I am an Affiliate (non-clinical Fellow) of the Royal College of Physicians and an Associate of the British Society of NeuroRadiologists (BSNR). Since one of my main current interests is in `Diabetes and the Brain´, I am a Professional Member of Diabetes UK and a member of NeuroDiab.

Current Projects:

Key Publications:

  1. Selvarajah D, Wilkinson ID, Gandhi R, Griffiths PD, Tesfaye S. (2011). Microvascular Perfusion Abnormalities of the Thalamus in Painful but Not Painless Diabetic Polyneuropathy: A clue to the pathogenesis of pain in type 1 diabetes. Diabetes Care. 34(3):718-20.

  2. Romanowski CA, Wilkinson ID. (2011). Atrophy: When too much atrophy is too little brain. Neuroradiology 53 Suppl 1:133-9.

  3. Selvarajah D, Wilkinson ID, Davies J, Gandhi R, Tesfaye S. (2011). Central nervous system involvement in diabetic neuropathy. Curr Diab Rep. 11(4):310-22.

  4. Hadjivassiliou M, Wallis LI, Hoggard N, Grünewald RA, Griffiths PD, Wilkinson ID. (2012). MR spectroscopy and atrophy in Gluten, Friedreich's and SCA6 ataxias. Act Neurol Scand. 126(2):138-43.

  5. Gwilliam MN, Hoggard N, Capener D, Singh P, Marzo A, Verma PK, Wilkinson ID. (2009). MR derived volumetric flow rate waveforms at locations within the common carotid, internal carotid, and basilar arteries. Journal of Cerebral Blood Flow and Metabolism 29: 1975-1982.

  6. Giesel FL, Mehndiratta A, Risse F, Rius M, Zechmann CM, von Tengg-Kobligk H, Gerigk L, Kauczor HU, Politi M, Essig M, Griffiths PD, Wilkinson ID. (2009). Intraindividual comparison between gadopentetate dimeglumine and gadobutrol for magnetic resonance perfusion in normal brain and intracranial tumors at 3 Tesla. Acta Radiol. 50(5):521-30

  7. Spence SA, Kaylor-Highes CJ, Farrow TF, Wilkinson ID. (2008). Speaking of secrets and lies: The contribution of ventrolateral prefrontal cortex to vocal deception. Neuroimage 40: 1411-1418.

  8. Selvarajah D, Wilkinson ID, Emery CJ, Shaw PJ, Griffiths PD, Gandhi R, Tesfaye S. (2008). Thalamic neuronal dysfunction and chronic sensorimotor distal symmetrical polyneuropathy in patients with type 1 diabetes militus. Diabetologia 51(11):2088-2092

  9. Laycock SK, Wilkinson ID, Wallis LI, Darwent G, Wonders S, Fawcett AJ, Griffiths PD, Nicolson RI. (2008). Cerebellar volume and cerebellar metabolic characteristics in adults with dyslexia. Ann. N.Y. Acad. Sci 1145:222-236.

  10. Wallis LI, Griffiths PD, Ritchie SJ, Romanowski CA, Darwent G, Wilkinson ID. (2007). Proton Spectroscopy and Imaging at 3T in Ataxia-Telangiectasia. AJNR American Journal of Neuroradiology 28: 79-83.

  11. Hunter MD, Eichoff SB, Miller TW, Farrow TF, Wilkinson ID, Woodruff PW. (2006). Neural activity in speech-sensitive auditory cortex during silence. Proceedings of the National Academy of Sciences of the USA 103: 189-194.

  12. Wilkinson ID, Jellinek DA, Levy D, Giesel FL, Miller BA, Griffiths PD. (2006). Dexamethasone alters cerebral perfusion and blood-tumour barrier kinetics of cerebral lesions on MRI. Neurosurgery 58: 640-646; discussion 646.

  13. Wilkinson ID, Romanowski CAJ, Jellinek DA, Morris J, Griffiths PD. (2003). Motor fMRI for pre- and intra-operative neurosurgical guidance. British Journal of Radiology 76: 98-103.

  14. Wilkinson ID, Griffiths PD, Hoggard N, Gaines P, Cleveland T, Macdonald S, McKevitt F, Venables GS. (2003). Short-term changes in cerebral micro-hemodynamics following carotid stenting assessed by MR perfusion imaging. AJNR Am J Neuroradiol 24(8):1501-1507.

  15. Eaton SEM, Harris ND, Rajbhandari SM, Greenwood P, Wilkinson ID, Ward JD, Griffiths PD, Tesfaye S. (2001). Spinal cord atrophy in diabetic peripheral neuropathy. Lancet 358:35-36.

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