The University of Sheffield
Department of Cardiovascular Science

Dr. Timothy Chico MBChB MRCP MD

Clinician Scientist and Honorary Consultant Cardiologist

Tim Chico

Department:
Department of Cardiovascular Science
University of Sheffield
Medical School
Beech Hill Road
Sheffield
S10 2RX

Office:
Lab D38
MRC Centre for Developmental and Biomedical Genetics
Firth Court
University of Sheffield
Western Bank
Sheffield
S10 2TF

Tel: +44 (0)114 222 2396/5
Tel Secretary: +44 (0)114 271 2052
Fax: +44 (0)114 271 1863
Email: t.j.chico@sheffield.ac.uk

Biography:

I graduated from Leeds Medical School in 1993. After General Medicine training I undertook an MD with Professor David Crossman at the University of Sheffield.

After postdoctoral research at Genentech Inc, I became a Clinical Lecturer in Cardiology in Sheffield. In 2004 I was awarded a GSK Clinician Scientist Fellowship to develop the zebrafish as a novel model of arteriogenesis.

Since 2006 I have been Senior Clinical Lecturer and honorary Consultant Cardiologist within the MRC Centre for Developmental and Biomedical Genetics and I am Deputy Director of the NIHR Cardiovascular Biomedical Research Unit.

Research Interests:

My research interests are in the molecular and genetic mechanisms controlling blood vessel development and collateral vessel formation after arterial occlusion.

Teaching Interests:

My teaching duties include clinical cardiology, developmental biology, cardiovascular physiology and the use of non-mammalian models of cardiovascular disease.

Professional Activities:

I am on the committee of the British Atherosclerosis Society and am editor of Genetics of Cardiovascular Disease, a volume in the series Progress in Molecular Biology and Translational Science.

Current Projects:

Key Publications:

  1. Bourke L, Chico TJ, Albertsen PC, Hamdy FC, Rosario DJ. Cardiovascular risk in androgen suppression: underappreciated, under-researched and unresolved. Heart. 2012 Mar;98(5):345-8
  2. Bugeon L, Taylor HB, Progatzky F, Lin MI, Ellis CD, Welsh N, Smith E, Vargesson N, Gray C, Renshaw SA, Chico TJ, Zon LI, Lamb J, Dallman MJ. The NOTCH pathway contributes to cell fate decision in myelopoiesis. Haematologica. 2011 Dec;96(12):1753-60
  3. Holden BJ, Bratt DG, Chico TJ. Molecular control of vascular development in the zebrafish. Birth Defects Res C Embryo Today. 2011 Jun;93(2):134-40
  4. Ellam T, Wilkie M, Chamberlain J, Crossman D, Eastell R, Francis S, Chico TJ. Dietary Phosphate Modulates Atherogenesis and Insulin Resistance in Apolipoprotein E Knockout Mice. Arterioscler Thromb Vasc Biol. 2011 Sep;31(9): 1988-90
  5. Gray C, Loynes CA, Whyte MK, Crossman DC, Renshaw SA, Chico TJ. Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish. Thromb Haemost. 2011 May;105(5):811-9
  6. Bourke L, Tew GA, Milo M, Crossman DC, Saxton JM, Chico TJ. Study protocol: a randomised controlled trial investigating the effect of exercise training on peripheral blood gene expression in patients with stable angina. BMC Public Health. 2010 Oct 18;10:620
  7. McLeish JA, Chico TJ, Taylor HB, Tucker C, Donaldson K, Brown SB. Skin exposure to micro- and nano-particles can cause haemostasis in zebrafish larvae. Thromb Haemost. 2010 Feb 19;103(4)
  8. Chico TJ, Milo M, Crossman DC. The genetics of cardiovascular disease: new insights from emerging approaches. J Pathol. 2010 Jan;220(2):186-97.
  9. Packham IM, Gray C, Heath PR, Hellewell PG, Ingham PW, Crossman DC, Milo M, Chico TJ. Microarray profiling reveals CXCR4a is downregulated by blood flow in vivo and mediates collateral formation in zebrafish embryos. Physiol Genomics. 2009 Aug 7;38(3):319-27.
  10. Chico TJ, Ingham PW, Crossman DC. Modelling cardiovascular disease in the zebrafish. Trends in Cardiovascular Medicine 2008 18(4):150-5.
  11. Gray C, Packham IM, Wurmser F, Eastley NC, Hellewell PG, Ingham PW, Crossman DC, Chico TJ. Ischemia is not required for arteriogenesis in zebrafish embryos. Arterioscler Thromb Vasc Biol 2007 Oct;27(10):2135-41.
  12. Greve JM, Chico TJ, Goldman H, Bunting S, Peale FV Jr, Daugherty A, van Bruggen N, Williams SP. Magnetic resonance angiography reveals therapeutic enlargement of collateral vessels induced by VEGF in a murine model of peripheral arterial disease. J Magn Reson Imaging 2006 Nov;24(5):1124-32.

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