The University of Sheffield
Department of Biomedical Science

Dr Freek van Eeden

Department of Biomedical Science
The University of Sheffield
Western Bank
Sheffield S10 2TN
United Kingdom

Senior Lecturer
Room: D18 Firth Court
Telephone: +44 (0) 114 222 2348
email : f.j.vaneeden@sheffield.ac.uk

Career history

Research interests

Using the zebrafish as a genetic tool to study development and disease. We are interested in understanding the role of the patched genes in Hedgehog signaling. In addition, we have created a knockout for the von Hippel Lindau disease (VHL) gene and are interested in modeling VHL deficient cancers in zebrafish.

Read more (Link to Centre for Developmental & Biomedical Genetics website)

Activities and distinctions

Funding

Recent publications

Watson O, Novodvorsky P, Gray C, Rothman AM, Lawrie A, Gerhardt H, Crossman DC, Haase A, McMahon K, Gering M, van Eeden FJ & Chico TJ (2013)
Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling.
Cardiovasc Res.

Kettleborough RNW, Busch-Nentwich EM, Harvey SA, Dooley CM, Sealy I, White RJ, Herd C, Fényes F, Mehroke S, Scahill C, Gibbons R, Wali N, Carruthers S, Hall A, Yen J, Stemple DL, De Bruijn E, Nijman IJ, Cuppen E & Van Eeden F (2013)
A systematic genome-wide analysis of zebrafish protein-coding gene function.
Nature, 496(7446), 494-497.

Chowdhury R, Candela-Lena JI, Chan MC, Greenald DJ, Yeoh KK, Tian YM, McDonough MA, Tumber A, Rose NR, Conejo-Garcia A, Demetriades M, Mathavan S, Kawamura A, Lee MK, van Eeden F, Pugh CW, Ratcliffe PJ & Schofield CJ (2013)
Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases.
ACS Chem Biol.

Kettleborough RN, Busch-Nentwich EM, Harvey SA, Dooley CM, de Bruijn E, van Eeden F, Sealy I, White RJ, Herd C, Nijman IJ, Fényes F, Mehroke S, Scahill C, Gibbons R, Wali N, Carruthers S, Hall A, Yen J, Cuppen E & Stemple DL (2013)
A systematic genome-wide analysis of zebrafish protein-coding gene function.
Nature, 496(7446), 494-497.

Basten SG, Davis EE, Gillis AJ, van Rooijen E, Stoop H, Babala N, Logister I, Heath ZG, Jonges TN, Katsanis N, Voest EE, van Eeden FJ, Medema RH, Ketting RF, Schulte-Merker S, Looijenga LH & Giles RH (2013)
Mutations in LRRC50 predispose zebrafish and humans to seminomas.

PLoS Genet, 9(4), e1003384.