Dr Freek van Eeden
Department of Biomedical Science
The University of Sheffield
Western Bank
Sheffield S10 2TN
United Kingdom
Senior Lecturer
Room: D18 Firth Court
Telephone: +44 (0) 114 222 2348
email : f.j.vaneeden@sheffield.ac.uk
Career history
- 2006- present: Senior Lecturer, University of Sheffield
- 1999 - 2005: Junior Group Leader Hubrecht Laboratory, Utrecht, The Netherlands
- 1997 - 1999: Post-doctoral worker, D. StJohnston Lab, Wellcome/CRC Inst. Cambridge UK
- 1992 - 1997: PhD, C. Nüsslein-Volhard Lab. Max Planck Inst. für Entwicklungsbiologie, Tübingen, Germany
- 1986 - 1992 MSc. Wageningen Agricultural University, The Netherlands
Research interests
Using the zebrafish as a genetic tool to study development and disease. We are interested in understanding the role of the patched genes in Hedgehog signaling. In addition, we have created a knockout for the von Hippel Lindau disease (VHL) gene and are interested in modeling VHL deficient cancers in zebrafish.
Read more (Link to Centre for Developmental & Biomedical Genetics website)
Activities and distinctions
- Invited teacher at regular EMBO courses at the MPI in Tübingen (recently also Sheffield)
- Presenter at open science days and public lectures in Utrecht/Wageningen
- International collaboration on TILLING with Hubrecht Laboratory Utrecht/Sanger Inst. Cambridge
Funding
Recent publications
Sapetto-Rebow B, McLoughlin SC, O'Shea LC, O'Leary O, Willer JR, Alvarez Y, Collery R, O'Sullivan J, Van Eeden F, Hensey C, Kennedy BN.
Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants.
BMC Dev Biol. 2011 11(1):71.
Ben J, Elworthy S, Ng AS, van Eeden F, Ingham PW.
Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates.
Development. 2011 138:4969-78.
van Rooijen E, Santhakumar K, Logister I, Voest E, Schulte-Merker S, Giles R, van Eeden F.
A zebrafish model for VHL and hypoxia signaling.
Methods Cell Biol. 2011;105:163-90.
van Rooijen E, Voest EE, Logister I, Bussmann J, Korving J, van Eeden FJ, Giles RH, Schulte-Merker S.
von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish.
Dis Model Mech. 2010 May-Jun;3(5-6):343-53.
Hammond KL, van Eeden FJ, Whitfield TT.
Repression of Hedgehog signalling is required for the acquisition of dorsolateral cell fates in the zebrafish otic vesicle.
Development. 2010 Apr;137(8):1361-71.
Kim HR, Richardson J, van Eeden F, Ingham PW
Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish.
BMC Biol. 2010 May 20;8(1):65. [Epub ahead of print]
van Rooijen E, Voest EE, Logister I, Korving J, Schwerte T, Schulte-Merker S, Giles RH, van Eeden FJ.
Zebrafish mutants in the von Hippel-Lindau (VHL) tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia.
Blood. 2009;113(25):6449-60.
Thomas NA, Koudijs M, van Eeden FJ, Joyner AL, Yelon D.
Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential.
Development. 2008 135:3789-99.
van Rooijen E, Giles RH, Voest EE, van Rooijen C, Schulte-Merker S, van Eeden FJ.
LRRC50, a conserved ciliary protein implicated in polycystic kidney disease.
J Am Soc Nephrol.
2008 Jun;19(6):1128-38.
Koudijs MJ, den Broeder MJ, Groot E, van Eeden FJ.
Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway.
BMC Dev Biol. 2008 Feb 19;8:15.