Pain and Inflammation
This theme embraces the physiology and pharmacology of neuro-immune interactions and its impact on inflammatory disorders such as Inflammatory Bowel Disease (IBD) and Asthma and the development of novel treatments. It includes studies on epithelial transport and barrier function, the mechanisms that lead to immune cell activation and resolution and the role of inflammatory mediators in neural activation, for example in pain signalling. The work encompasses isolated cells and animal models of human disease.
| Principal Investigator | Research Area |
|---|---|
| Professor David Grundy | Neurogastroenterology – the neural control of gut function |
| Dr. Mohammed Nassar | Role of sodium channels in pain |
| Dr. Steve Renshaw | The genetic controls of resolution of neutrophilic inflammation |
| Dr. Louise Robson | Role of ion channels in epithelial health and disease |
| Dr. Liz Seward | Ion channels, receptors and regulation of exocytosis |
| Dr. Gordon Cooper | Transport of gases and urea by membrane proteins |