Musculoskeletal and Cardiovascular Biology

This theme embraces research into the cytoskeleton, musculoskeletal development and cardiovascular biology. In vitro and in vivo experimental animal models are used to study muscular dystrophy, cranio-facial abnormalities and diseases associated with the major developmental signalling pathways such as retinoic acid, Wnt, Fibroblast Growth Factor (FGF) and Hedgehog (Hh).

Such models of human disease give powerful insights into the molecular, cellular and physiological basis of pathologies as well as providing assays for the identification of potential therapeutic agents.