Dr Henry Roehl

Henry Roehl Senior Lecturer
Department of Biomedical Science
The University of Sheffield
Sheffield S10 2TN
United Kingdom

Tel: +44 (0) 114 222 2351
Fax: +44 (0) 114 222 2788

Room: C21 Firth Court
email : h.roehl@sheffield.ac.uk

Research interests

The Roehl Laboratory uses zebrafish as a model organism to study musculoskeletal development and disease.

Career history

2004-present: MRC Centre for Developmental and Biomedical Genetics, University of Sheffield
2011-present: Senior Lecturer, University of Sheffield
2002-present: Lecturer, University of Sheffield
1997-2002: Postdoctoral Fellow, Max-Planck-Institut, Tuebingen. Research advisor: Dr. Nuesslein-Volhard
1994-1997: Ph.D. Genetics University of Wisconsin-Madison. Research advisor: Dr. Judith Kimble
1990-1994: Masters Genetics University of Wisconsin-Madison. Research advisor: Dr. Judith Kimble
1983-1988: B.S. Biology, Antioch College

Activities and distinctions

Academic Editor PLoS ONE (2011- present)
Advisor to RSPCA on manual entitled: Housing and care of aquatic species Zebrafish (2010)
Member of the Mellanby Centre for bone research (2009-present)
MHE Scientific Advisory Board USA (2008-present)
Member of the MRC College of Experts (2006-2010)
Membership in two EU funded, FW6 consortiums: ZF Models (2003-2008) and Cells to organs (2003-2009)
Member of the Tuebingen 2000 Screen Consortium (2000-2002)
EMBO Long-term Fellowship (1997-2000)
NIH Postgraduate Training Fellowship (1990-1994)
Review for Developmental Dynamics, Developmental Biology, Journal of Experimental Zoology, Current Biology, PLoS One, PLoS Genetics, Development, Biotechnology Journal, FASEB Journal.

Invited lectures and workshops

UK Mesenchymal Stem Cell Meeting. Birmingham, UK (1/7/11)
Hereditary Multiple Exostoses Support Group Meeting. Liverpool, UK (26/3/11)
Institute of Animal Technology Meeting. Sheffield, UK (8/9/10)
Course teacher in EMBO practical course “Animal models for physiology and disease” UK (19/7/10)
Gordon Conference Proteoglycans, Proctor Academy, Andover, NH, USA (11/7/10)
Third International MHE/MO/HME Research Conference, Boston, USA (29/10/09)
Bone Research Society's annual meeting. London, UK (15/06/09)
Tissue Specification and Organogenesis. Lisbon, Portugal (6/2/09)
Developmental Biology Seminar Series. Gurdon Institute, Cambridge UK (6/6/08)
Society for Glycobiology annual meeting. Boston USA (12/11/07)
Course teacher in EMBO practical course "Animal models for development, physiology and disease" UK (16/7/07)
Craniofacial Development seminar series. KCL, London UK (11/6/07)
Genetics and Development seminar series, LIMR, Mill Hill, UK (12/6/07)
Gordon Conference Proteoglycans, Proctor Academy, Andover, NH, USA (11/7/06)
IMP seminar series, Research Institute of Molecular Pathology, Vienna, AT (2/2/06)

Funding

Research supervision

Phil Jankun, 2011 until present
Tobias Stedman, 2011 until present
Montserrat Garcia Romero, 2011 until Present
Katharina Felber PhD awarded 2010
Maria Lecca, Masters awarded 2009
Ben Hearne, BMedSci Student 2009
Nan Li, PhD awarded 2008
Phil Elks (co-supervised by P.Croucher) PhD awarded 2007
Katharina Mebus (co-supervised by P.Croucher) PhD awarded 2007
Aurelie Clement (co-supervised by P. Ingham) PhD awarded 2007
Stephanie Collins, L4 project 2006
Dominik Paquet, Masters awarded 2005

Other lab members

Carlos Pereira da Cruz (Postdoc), 2011 until present
Matthew Jackson (visiting PhD), 2011 until present
Collins Mbaria (undergraduate volunteer) 2011
Harriet Doubleday (undergraduate volunteer) 2011
Leanne Lipscomb (visiting PhD), 2009 until present
Michael Trikic (visiting PhD), 2005-2009
Robert Knight (Postdoc) 2004-2007
Malgorzata Wiweger (Postdoc) 2004-2008
James Williams (technician) 2004-2006
Patricia Cucchi-Mouillot (visiting scientist) 2004-2005

Viva voce

Giuliano Giuliani (Sheffield) 2011
Victor Muthu (Sheffield) 2011
Theo Hill (IMP Vienna) 2006

Recent publications

Sousa S, Afonso N, Bensimon-Brito A, Fonseca M, Simões M, Leon J, Roehl H, Cancela ML, Jacinto A.
Differentiated skeletal cells contribute to blastema formation during zebrafish fin regeneration.
Development. 2011 138:3897-905.

Thompson MJ, Louth JC, Ferrara S, Jackson MP, Sorrell FJ, Cochrane EJ, Gever J, Baxendale S, Silber BM, Roehl HH, Chen B.
Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity.
Eur J Med Chem. 2011 Sep;46(9):4125-32. Epub 2011 Jun 17.

Knight, RD, Mebus, K, d'Angelo, Yokoya K, Heanue T, Roehl H.
Ret signalling integrates a craniofacial muscle module during development.
Development. 2011 138(10):2015-2024

Felber K, Croucher P, Roehl HH.
Hedgehog signalling is required for perichondral osteoblast differentiation in zebrafish.
Mech Dev. 2011 Jan-Feb;128(1-2):141-52. Epub 2010 Nov 30.

Roehl H and Pacifici M
Sugars, bones and a disease called Multiple Hereditary Exostoses.
Dev Dyn. 2010 Jun;239(6):1901-4.

Li N, Kelsh RN, Croucher P, Roehl HH.
Regulation of neural crest cell fate by the retinoic acid and Pparg signalling pathways.
Development. 2010. 137(3):389-94.

Li N, Felber K, Elks P, Croucher P, Roehl HH.
Tracking gene expression during zebrafish osteoblast differentiation.
Dev Dyn. 2009 Feb;238(2):459-66.

Clément A, Wiweger M, von der Hardt S, Rusch MA, Selleck SB, Chien CB, Roehl HH.
Regulation of zebrafish skeletogenesis by ext2/dackel and papst1/pinscher.
PLoS Genet. 2008 Jul 25;4(7):e1000136.

Laue K, Daujat S, Crump JG, Plaster N, Roehl HH; Tübingen 2000 Screen Consortium, Kimmel CB, Schneider R, Hammerschmidt M.
The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity.
Development. 2008 Jun;135(11):1935-46.

Knight RD, Mebus K, Roehl HH.
Mandibular arch muscle identity is regulated by a conserved molecular process during vertebrate development.
J Exp Zoolog B Mol Dev Evol. 2008 Jun 15;310(4):355-69.

Last updated: 26 February 2013