- 2004-present: MRC Centre for Developmental and Biomedical Genetics, University of Sheffield
- 2011-present: Senior Lecturer, University of Sheffield
- 2002-present: Lecturer, University of Sheffield
- 1997-2002: Postdoctoral Fellow, Max-Planck-Institut, Tuebingen. Research advisor: Dr. Nuesslein-Volhard
- 1994-1997: Ph.D. Genetics University of Wisconsin-Madison. Research advisor: Dr. Judith Kimble
- 1990-1994: Masters Genetics University of Wisconsin-Madison. Research advisor: Dr. Judith Kimble
- 1983-1988: B.S. Biology, Antioch College
The Roehl Laboratory uses zebrafish as a model organism to study musculoskeletal development and disease.
My research group is part of the Bateson Centre.
Roehl Lab Group page
Activities and distinctions
- Co-organiser of the EMBO 2016 Regen meeting
- Academic Editor PLoS ONE (2011- present)
- Advisor to RSPCA on manual entitled: Housing and care of aquatic species Zebrafish (2010)
- Member of the Mellanby Centre for bone research (2009-present)
- MHE Scientific Advisory Board USA (2008-present)
- Member of the MRC College of Experts (2006-2010)
- Membership in two EU funded, FW6 consortiums: ZF Models (2003-2008) and Cells to organs (2003-2009)
- Member of the Tuebingen 2000 Screen Consortium (2000-2002)
- EMBO Long-term Fellowship (1997-2000)
- NIH Postgraduate Training Fellowship (1990-1994)
- Review for Developmental Dynamics, Developmental Biology, Journal of Experimental Zoology, Current Biology, PLoS One, PLoS Genetics, Development, Biotechnology Journal, FASEB Journal.
- BSDB Committee Member
- PLoS One Academic Editor
Invited lectures and workshops
- UK Mesenchymal Stem Cell Meeting. Birmingham, UK (1/7/11)
- Hereditary Multiple Exostoses Support Group Meeting. Liverpool, UK (26/3/11)
- Institute of Animal Technology Meeting. Sheffield, UK (8/9/10)
- Course teacher in EMBO practical course “Animal models for physiology and disease” UK (19/7/10)
- Gordon Conference Proteoglycans, Proctor Academy, Andover, NH, USA (11/7/10)
- Third International MHE/MO/HME Research Conference, Boston, USA (29/10/09)
- Bone Research Society's annual meeting. London, UK (15/06/09)
- Tissue Specification and Organogenesis. Lisbon, Portugal (6/2/09)
- Developmental Biology Seminar Series. Gurdon Institute, Cambridge UK (6/6/08)
- Society for Glycobiology annual meeting. Boston USA (12/11/07)
- Course teacher in EMBO practical course "Animal models for development, physiology and disease" UK (16/7/07)
- Craniofacial Development seminar series. KCL, London UK (11/6/07)
- Genetics and Development seminar series, LIMR, Mill Hill, UK (12/6/07)
- Gordon Conference Proteoglycans, Proctor Academy, Andover, NH, USA (11/7/06)
- IMP seminar series, Research Institute of Molecular Pathology, Vienna, AT (2/2/06)
- Cancer Research UK
- Medical Research Council
- Felber K, Elks PM, Lecca M & Roehl HH (2015)
Expression of osterix Is Regulated by FGF and Wnt/β-Catenin Signalling during Osteoblast Differentiation.
PLOS ONE, 10(12), e0144982-e0144982.
- Dyer C, Blanc E, Hanisch A, Roehl H, Otto GW, Yu T, Basson MA & Knight R (2014)
A bi-modal function of Wnt signalling directs an FGF activity gradient to spatially regulate neuronal differentiation in the midbrain.
Development, 141(1), 63-72.
- Gray C, Bratt D, Lees J, daCosta M, Plant K, Watson OJ, Solaymani-Kohal S, Tazzyman S, Serbanovic-Canic J, Crossman DC, Keavney BD, Haase A, McMahon K, Gering M, Roehl H, Evans PC & Chico TJ (2013)
Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development.
Arterioscler Thromb Vasc Biol, 33(6), 1257-1263
Full publications list
Modelling skeletal disease in zebrafish
How do developmental signalling pathways regulate osteoblast differentiation during development and skeletal repair?
Osteoblasts in zebrafish follow the same differentiation pathway as in mammals: The runx2 genes are expressed in early skeletal precursors, followed by osterix and then finally by genes encoding bone proteins such as Osteonectin and Collagen1.
We have analysed how different signalling pathways regulate these steps during osteoblastogenesis using heatshock induction of signalling pathway components and pharmaceuticals that target individual pathways.
Our work has shed light on how stem cells differentiate in vivo and may help to develop regenerative therapies for skeletal diseases such as osteoarthritis and osteoporosis. We have also found a link between osteoblast and adipocyte differentiation in vivo that may help us to unravel the genetic origins of diseases such as diabetes and obesity.
Current lab members
See: Roehl lab members
Former lab members
- Carlos Pereira da Cruz (Postdoc), 2011 until present
- Matthew Jackson (visiting PhD), 2011 until present
- Collins Mbaria (undergraduate volunteer) 2011
- Harriet Doubleday (undergraduate volunteer) 2011
- Leanne Lipscomb (visiting PhD), 2009 until present
- Michael Trikic (visiting PhD), 2005-2009
- Robert Knight (Postdoc) 2004-2007
- Malgorzata Wiweger (Postdoc) 2004-2008
- James Williams (technician) 2004-2006
- Patricia Cucchi-Mouillot (visiting scientist) 2004-2005
- Phil Jankun, 2011 until present
- Tobias Stedman, 2011 until present
- Montserrat Garcia Romero, 2011 until Present
- Katharina Felber PhD awarded 2010
- Maria Lecca, Masters awarded 2009
- Ben Hearne, BMedSci Student 2009
- Nan Li, PhD awarded 2008
- Phil Elks (co-supervised by P.Croucher) PhD awarded 2007
- Katharina Mebus (co-supervised by P.Croucher) PhD awarded 2007
- Aurelie Clement (co-supervised by P. Ingham) PhD awarded 2007
- Stephanie Collins, L4 project 2006
- Dominik Paquet, Masters awarded 2005
- Giuliano Giuliani (Sheffield) 2011
- Victor Muthu (Sheffield) 2011
- Theo Hill (IMP Vienna) 2006