Recent Publications

Andrews PW

The International Stem Cell Initiative, Amps K, Andrews PW, et al.
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.
Nat Biotechnol. 2011 29:1132-1144.

Sood A, Salih S, Roh D, Lacharme-Lora L, Parry M, Hardiman B, Keehan R, Grummer R, Winterhager E, Gokhale PJ, Andrews PW, Abbott C, Forbes K, Westwood M, Aplin JD, Ingham E, Papageorgiou I, Berry M, Liu J, Dick AD, Garland RJ, Williams N, Singh R, Simon AK, Lewis M, Ham J, Roger L, Baird DM, Crompton LA, Caldwell MA, Swalwell H, Birch-Machin M, Lopez-Castejon G, Randall A, Lin H, Suleiman MS, Evans WH, Newson R, Case CP.
Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness.
Nat Nanotechnol. 2011 6:824-33.

Barbaric I, Jones M, Buchner K, Baker D, Andrews PW, Moore HD.
Pinacidil enhances survival of cryopreserved human embryonic stem cells.
Cryobiology. 2011 63:298-305.

Andrews PW.
Toward safer regenerative medicine.
Nat Biotechnol. 2011 29:803-5. No abstract available.

Tonge PD, Shigeta M, Schroeder T, Andrews PW.
Functionally defined substates within the human embryonic stem cell compartment.
Stem Cell Res. 2011 7:145-53.

Fazeli A, Liew CG, Matin MM, Elliott S, Jeanmeure LF, Wright PC, Moore H, Andrews PW.
Altered patterns of differentiation in karyotypically abnormal human embryonic stem cells.
Int J Dev Biol. 2011 55:175-80.

Wright A, Andrews N, Bardsley K, Nielsen JE, Avery K, Pewsey E, Jones M, Harley D, Nielsen AR, Moore H, Gokhale P, Rajpert-De Meyts E, Andrews PW, Walsh J, Harrison NJ.
Mapping the stem cell state: eight novel human embryonic stem and embryonal carcinoma cell antibodies.
Int J Androl. 2011 34: e175-87;

Goldring CE, Duffy PA, Benvenisty N, Andrews PW, Ben-David U, Eakins R, French N, Hanley NA, Kelly L, Kitteringham NR, Kurth J, Ladenheim D, Laverty H, McBlane J, Narayanan G, Patel S, Reinhardt J, Rossi A, Sharpe M, Park BK.
Assessing the safety of stem cell therapeutics.
Cell Stem Cell. 2011 8:618-28. Review.

Barbaric I, Jones M, Harley DJ, Gokhale PJ, Andrews PW.
High-content screening for chemical modulators of embryonal carcinoma cell differentiation and survival.
J Biomol Screen. 2011 16:603-17.

Battaglia G

Hearnden V, MacNeil S, Battaglia G.
Tracking nanoparticles in three-dimensional tissue-engineered models using confocal laser scanning microscopy.
Methods Mol Biol. 2011;695:41-51.

Flores-Merino MV, Chirasatitsin S, Lopresti C, Reilly GC, Battaglia G, Engler AJ.
Nanoscopic mechanical anisotropy in hydrogel surfaces.
Soft Matter. 2010 6:4466-4470.

Murdoch C, Reeves KJ, Hearnden V, Colley H, Massignani M, Canton I, Madsen J, Blanazs A, Armes SP, Lewis AL, Macneil S, Brown NJ, Thornhill MH, Battaglia G.
Internalization and biodistribution of polymersomes into oral squamous cell carcinoma cells in vitro and in vivo.
Nanomedicine (Lond). 2010 5:1025-36.

Lomas H, Du J, Canton I, Madsen J, Warren N, Armes SP, Lewis AL, Battaglia G.
Efficient encapsulation of plasmid DNA in pH-sensitive PMPC-PDPA polymersomes: study of the effect of PDPA block length on copolymer-DNA binding affinity.
Macromol Biosci. 2010 May 14;10(5):513-30.

Brown L, McArthur SL, Wright PC, Lewis A, Battaglia G.
Polymersome production on a microfluidic platform using pH sensitive block copolymers.
Lab Chip. 2010 May 17. [Epub ahead of print]

Massignani M, Canton I, Sun T, Hearnden V, Macneil S, Blanazs A, Armes SP, Lewis A, Battaglia G.
Enhanced fluorescence imaging of live cells by effective cytosolic delivery of probes.
PLoS One. 2010 May 3;5(5):e10459.

Picard C, Hearnden V, Massignani M, Achouri S, Battaglia G, MacNeil S, Donald A.
A micro-incubator for cell and tissue imaging.
Biotechniques. 2010 Feb;48(2):135-8.

Borycki AG

Van Hateren NJ, Das RM, Hautbergue GM, Borycki AG, Placzek M, Wilson SA.
FatJ acts via the Hippo mediator Yap1 to restrict the size of neural progenitor cell pools.
Development. 2011 May;138(10):1893-1902.

Coy S, Caamaño JH, Carvajal J, Cleary ML, Borycki AG.
A Novel Gli3 Enhancer Controls the Gli3 Spatiotemporal Expression Pattern through a TALE Homeodomain Protein Binding Site.
Mol Cell Biol. 2011 Apr;31(7):1432-43

Coy SE, Borycki AG.
Expression analysis of TALE family transcription factors during avian development.
Dev Dyn. 2010 Apr;239(4):1234-45.

Anderson C, Thorsteinsdóttir S, Borycki AG.
Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome.
Development. 2009 Oct;136(20):3495-504.

Anderson C, Thorsteinsdóttir S, Borycki AG.
Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome.
Development. 2009 Oct;136(20):3495-504.

Chico TJ

Holden BJ, Bratt DG, Chico TJ.
Molecular control of vascular development in the zebrafish.
Birth Defects Res C Embryo Today. 2011 Jun;93(2):134-40.

Ellam T, Wilkie M, Chamberlain J, Crossman D, Eastell R, Francis S, Chico TJ.
Dietary Phosphate Modulates Atherogenesis and Insulin Resistance in Apolipoprotein E Knockout Mice.
Arterioscler Thromb Vasc Biol. 2011 Jun 2. [Epub ahead of print]

Gray C, Loynes CA, Whyte MK, Crossman DC, Renshaw SA, Chico TJ.
Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish.
Thromb Haemost. 2011 May;105(5):811-9.

Bourke L, Tew GA, Milo M, Crossman DC, Saxton JM, Chico TJ.
Study protocol: a randomised controlled trial investigating the effect of exercise training on peripheral blood gene expression in patients with stable angina.
BMC Public Health. 2010 10:620.

McLeish JA, Chico TJ, Taylor HB, Tucker C, Donaldson K, Brown SB.
Skin exposure to micro- and nano-particles can cause haemostasis in zebrafish larvae.
Thromb Haemost. 2010 Mar 31;103(4):797-807

Chico TJ, Milo M, Crossman DC.
The genetics of cardiovascular disease: new insights from emerging approaches.
J Pathol. 2010 Jan;220(2):186-97. Review.

Cooper GJ

Abbas L, Hajihashemi S, Stead LF, Cooper GJ, Ware TL, Munsey TS, Whitfield TT, White SJ.
Functional and developmental expression of a zebrafish Kir1.1 (ROMK) potassium channel homologue Kcnj1.
J Physiol. 2011 Mar 15;589(Pt 6):1489-503.

Laycock Cooper GJ, Ong AC, Robson L.
A novel dephosphorylation-activated conductance in a mouse renal collecting duct cell line.
Exp Physiol. 2009 Aug;94(8):914-27.

Stewart GS, Thistlethwaite A, Lees H, Cooper GJ, Smith CP.
Vasopressin regulation of the renal UT-A3 urea transporter.
Am J Physiol Renal Physiol. 2009 Mar;296(3):F642-8.

Cunliffe VT

Lightman EG, Harrison MR, Cunliffe VT.
Opposing actions of histone deacetylase 1 and Notch signalling restrict expression of erm and fgf20a to hindbrain rhombomere centres during zebrafish neurogenesis.
Int J Dev Biol. 2011;55(6):597-602.

Harrison MR, Georgiou AS, Spaink HP, Cunliffe VT.
The epigenetic regulator Histone Deacetylase 1 promotes transcription of a core neurogenic programme in zebrafish embryos.
BMC Genomics. 2011 Jan 12;12(1):24. [Epub ahead of print]PMID: 21226904

Butler R, Wood JD, Landers JA, Cunliffe VT.
Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia.
Dis Model Mech. 2010 Sep 9. [Epub ahead of print]

Walker RA, Cunliffe VT, Whittle JD, Steele DA, Short RD.
Submillimeter-scale surface gradients of immobilized protein ligands.
Langmuir. 2009 Apr 21;25(8):4243-6.

Wood JD, Bonath F, Kumar S, Ross CA, Cunliffe VT.
Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain.
Hum Mol Genet. 2009 Feb 1;18(3):391-404. Epub 2008 Nov 7.

Furley AJ

Xenaki D, Martin IB, Yoshida L, Ohyama K, Gennarini G, Grumet M, Sakurai T, Furley AJ.
F3/contactin and TAG1 play antagonistic roles in the regulation of sonic hedgehog-induced cerebellar granule neuron progenitor proliferation.
Development. 2011 138:519-29.

Grundy D

Jiang W, Adam IJ, Kitsanta P, Tiernan J, Hill C, Shorthouse A, Grundy D.
'First-in-man': characterising the mechanosensitivity of human colonic afferents.
Gut. 2011 60:281-2. Epub 2010 Nov 23.

Krueger D, Foerster M, Mueller K, Zeller F, Slotta-Huspenina J, Donovan J, Grundy D, Schemann M.
Signaling mechanisms involved in the intestinal pro-secretory actions of hydrogen sulfide.
Neurogastroenterol Motil. 2010 22:1224-31, e319-20.

Lubbers T, De Haan JJ, Hadfoune M, Zhang Y, Luyer MD, Grundy D, Buurman WA, Greve JW.
Lipid-enriched enteral nutrition controls the inflammatory response in murine Gram-negative sepsis.
Crit Care Med. 2010 38:1996-2002.

Mahmoud ZN, Grundy DJ, Channon KJ, Woolfson DN.
The non-covalent decoration of self-assembling protein fibers.
Biomaterials. 2010 31:7468-74. Epub 2010 Jul 16.

Keating C, Martinez V, Ewart L, Gibbons S, Grundy L, Valentin JP, Grundy D.
The validation of an in vitro colonic motility assay as a biomarker for gastrointestinal adverse drug reactions.
Toxicol Appl Pharmacol. 2010 Jun 15;245(3):299-309.

Daly DM, Chess-Williams R, Chapple C, Grundy D.
Reply from Authors re: Delphine Behr-Roussel, Francois A. Giuliano. Sensory Effects of Antimuscarinics: Still a Matter of Debate. Eur Urol. In press. doi:10.1016/j.eururo.2010.01.010.
Eur Urol. 2010 Feb 4. [Epub ahead of print]

Daly DM, Chess-Williams R, Chapple C, Grundy D.
The Inhibitory Role of Acetylcholine and Muscarinic Receptors in Bladder Afferent Activity.
Eur Urol. 2010 Jan 4. [Epub ahead of print]

Holley MC

Zampini V, Rüttiger L, Johnson S, Franz C, Furness DN, Waldhaus J, Xiong H, Hackney CM, Holley MC, Offenhauser N, Di Fiore PP, Knipper M, Masetto S & Marcotti W.
Eps8 Regulates Hair Bundle Length and Functional Maturation of Mammalian Auditory Hair Cells.
PloS Biology 2011 Apr;9(4):e1001048.

Kuhn S, Johnson SL, Furness DN, Chen J, Ingham N, Hilton JM, Steffes G, Lewis MA, Zampini V, Hackney CM, Masetto S, Holley MC, Steel KP & Marcotti W.
miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells.
Proc Natl Acad Sci USA 108:2355-60.

Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Hossain MA, Suzuki A, Holley MC, Tokuda M.
Phosphatase and tensin homolog deleted on chromosome 10 regulates sensory cell proliferation and differentiation of hair bundles in the mammalian cochlea.
Neuroscience. 2010. 170:1304-13.

Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Suzuki A, Holley M, Tokuda M.
Role of phosphatase and tensin homolog in the development of the mammalian auditory system.
Neuroreport. 2010 Jul 14;21(10):731-5.

Honkela A, Milo M, Holley M, Rattray M, Lawrence ND
Ranking of gene regulators through differential equations and Gaussian processes.
Proceedings of 2010 IEEE International Workshop on Machine Learning for Signal Processing.

Sekiya T, Matsumoto M, Kojima K, Ono K, Kikkawa Y, Kada S, Ogita H, Horie R, Viola A, Holley M, Ito J
Mechanical stress-induced reactive gliosis in the auditory nerve and cochlear nucleus;
J Neurosurg. 2010 Apr 2. [Epub ahead of print]

Holley M, Rhodes C, Kneebone A, Herde MK, Fleming M, Steel KP
Emx2 and early hair cell development in the mouse inner ear.
Dev Biol. Feb 9. 2010 [Epub ahead of print]

Sanchez-Calderon H, Rodriguez-de la Rosa L, Milo M, Pichel JG, Holley M, Varela-Nieto I
RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors.
PLoS One, 2010 5:e8699.

Ingham PW

Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates.
Ben J, Elworthy S, Ng AS, van Eeden F, Ingham PW.
Development. 2011 138:4969-78.

Bretaud S, Macraild S, Ingham PW, Bandmann O.
The Influence of the Zebrafish Genetic Background on Parkinson's Disease-Related Aspects.
Zebrafish. 2011 Sep;8(3):103-8. Epub 2011 Jul 11.

Elks PM, van Eeden FJ, Dixon G, Wang X, Reyes-Aldasoro CC, Ingham PW, Whyte MK, Walmsley SR, Renshaw SA.
Activation of Hif-1alpha delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model.
Blood. 2011 Jul 21;118(3):712-22. Epub 2011 May 9.

Ingham PW, Nakano Y, Seger C.
Mechanisms and functions of Hedgehog signalling across the metazoa.
Nat Rev Genet. 2011 Jun;12(6):393-406.

Maurya AK, Tan H, Souren M, Wang X, Wittbrodt J, Ingham PW.
Integration of Hedgehog and BMP signalling by the engrailed2a gene in the zebrafish myotome.
Development. 2011 Feb;138(4):755-65.

Juusola M

Winder, S.J.*, Lipscomb, L., Parkin, C.A. & Juusola, M. (2011).
The proteasomal inhibitor MG132 prevents muscular dystrophy in zebrafish.
PLoS Curr. 2011 Nov 17;3

Abou Tayoun, A.N., Li, X., Chu, B., Hardie, R.C., Juusola, M.* & Dolph, P.J.* (2011).
The Drosophila SK channel (dSK) contributes to photoreceptor performance by mediating sensitivity control at the first visual network.
J. Neurosci. 31: 13897-13910.

Gonzalez-Bellido, P.T., Wardill, T.J. & Juusola, M.* (2011)
Compound eyes and retinal information processing in miniature dipteran species match their specific ecological demands.
Proc Natl Acad Sci USA 108: 4224-4229.

Tang, S.* & Juusola, M.*
Intrinsic Activity in the Fly Brain Gates Visual Information during Behavioral Choices.
PLoS ONE 2010. 5(12): e14455. doi:10.1371/journal.pone.0014455

Marcotti W

Marcotti W.
Sharpey-Schafer Lecture: Functional assembly of mammalian cochlear hair cells.
Exp Physiol. 2011 Dec 16. [Epub ahead of print]

Johnson SL, Beurg M, Marcotti W & Fettipplace R
Prestin-driven cochlear amplification is not limited by the outer hair cell membrane time constant.
Neuron. 2011 70:1143-54

Alagramam KN, Goodyear RJ, Geng R, Furness DN, van Aken A, Marcotti W, Kros CJ & Richardson GP
Mice with mutations in protocadherin 15 and cadherin 23 lack tip links and have defects in mechanotransduction.
PloS One 6: 2011.  e19183.

Johnson SL, Eckrich T, Kuhn S, Zampini V, Franz C, Ranatunga KM, Roberts TP, Masetto S, Knipper M, Kros CJ & Marcotti W
Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells.
Nature Neurosci Published online: 15 May 2011 | doi:10.1038/nn.2803.

Zampini V, Rüttiger L, Johnson S, Franz C, Furness DN, Waldhaus J, Xiong H, Hackney CM, Holley MC, Offenhauser N, Di Fiore PP, Knipper M, Masetto S & Marcotti W
Eps8 Regulates Hair Bundle Length and Functional Maturation of Mammalian Auditory Hair Cells.
PloS Biology 2011. 9: e1001048.

Kuhn S, Johnson SL, Furness DN, Chen J, Ingham N, Hilton JM, Steffes G, Lewis MA, Zampini V, Hackney CM, Masetto S, Holley MC, Steel KP & Marcotti W
miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells.
Proc Natl Acad Sci USA 108:2355-60.

Johnson SL, Franz C, Kuhn S, Furness DN, Rüttiger L, Münkner S, Rivolta MN, Seward EP, Herschman HR, Engel J, Knipper M & Marcotti W (2010)
Synaptotagmin IV determines the linear calcium dependence of vesicle fusion at auditory ribbon synapses.
Nature Neurosci 13:45-52.

Marcotti W and Masetto S (2010)
Hair Cells.
In: Encyclopedia of Life Sciences (ELS). John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0000181.pub2. (Review)

Miller G

Miller G, Neilan M, Chia R, Gheryani N, Holt N, Charbit A, Wells S, Tucci V, Lalanne Z, Denny P, Fisher EMC, Cheeseman M, Askew GN and Dear TN.
ENU Mutagenesis Reveals a Novel Phenotype of Reduced Limb Strength in Mice Lacking Fibrillin 2.
PLoS ONE. 2010. 5, e9137.

Moore H

Blanco-Gelaz MA, Suarez-Alvarez B, Ligero G, Sanchez L, Vidal-Castiñeira JR, Coto E, Moore H, Menendez P, Lopez-Larrea C.
Endoplasmic Reticulum Stress Signals in Defined Human Embryonic Stem Cell Lines and Culture Conditions.
Stem Cell Rev. 2011 Jun;7(2):478.

Udayashankar R, Baker D, Tuckerman E, Laird S, Li TC, Moore HD.
Characterization of invasive trophoblasts generated from human embryonic stem cells.
Hum Reprod. 2011 Feb;26(2):398-406. Epub 2010 Dec 16.

Amps KJ, Jones M, Baker D, Moore HD.
In situ cryopreservation of human embryonic stem cells in gas-permeable membrane culture cassettes for high post-thaw yield and good manufacturing practice.
Cryobiology. 2010 Jun;60(3):344-50. Epub 2010 Mar 27

Hemberger M, Udayashankar R, Tesar P, Moore H, Burton GJ.
ELF5-enforced transcriptional networks define an epigenetically regulated trophoblast stem cell compartment in the human placenta.
Hum Mol Genet. 2010 Jun 15;19(12):2456-67.

Elisa Närvä, Reija Autio, Nelly Rahkonen, Lingjia Kong, Neil Harrison, Danny Kitsberg, Lodovica Borghese, Joseph Itskovitz-Eldor, Omid Rasool, Petr Dvorak, Outi Hovatta, Timo Otonkoski, Timo Tuuri, Wei Cui, Oliver Brüstle, Duncan Baker, Edna Maltby, Harry D Moore, Nissim Benvenisty, Peter W Andrews, Olli Yli-Harja & Riitta
High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity
Nature Biotechnology, Volume: 28, pp 371–377, 2010 doi:10.1038/nbt.16158
Abstract (ESTOOLS ref 81) Press release

Suárez-Alvarez B, Rodriguez RM, Calvanese V, Blanco-Gelaz MA, Suhr ST, Ortega F, Otero J, Cibelli JB, Moore H, Fraga MF, López-Larrea C.
Epigenetic mechanisms regulate MHC and antigen processing molecules in human embryonic and induced pluripotent stem cells.
PLoS One. 2010 Apr 16;5(4):e10192.

Nassar MA

Zhao J, Yuan G, Cendan CM, Nassar MA, Lagerstrom MC, Kullander K, Gavazzi I, Wood JN.
Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain.
Mol Pain. 2010 Nov 8;6(1):77. [Epub ahead of print] 

Zhao J, Lee MC, Momin A, Cendan CM, Shepherd ST, Baker MD, Asante C, Bee L, Bethry A, Perkins JR, Nassar MA, Abrahamsen B, Dickenson A, Cobb BS, Merkenschlager M, Wood JN.
Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds.
J Neurosci. 2010 Aug 11;30(32):10860-71. 

Golden JP, Hoshi M, Nassar MA, Enomoto H, Wood JN, Milbrandt J, Gereau RW 4th, Johnson EM Jr, Jain S.
RET signaling is required for survival and normal function of nonpeptidergic nociceptors.
J Neurosci. 2010 Mar 17;30(11):3983-94. 

Eijkelkamp N, Heijnen CJ, Willemen HL, Deumens R, Joosten EA, Kleibeuker W, den Hartog IJ, van Velthoven CT, Nijboer C, Nassar MA, Dorn GW 2nd, Wood JN, Kavelaars A.
GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain.
J Neurosci. 2010 Feb 10;30(6):2138-49.

Placzek M

FGF-dependent midline-derived progenitor cells in hypothalamic infundibular development.
Pearson CA, Ohyama K, Manning L, Aghamohammadzadeh S, Sang H, Placzek M.
Development. 2011 138:2613-24.

FatJ acts via the Hippo mediator Yap1 to restrict the size of neural progenitor cell pools.
Van Hateren NJ, Das RM, Hautbergue GM, Borycki AG, Placzek M, Wilson SA.
Development. 2011 138:1893-902.

Rashbass P

Boroviak T, Rashbass P.
The apical polarity determinant Crumbs 2 is a novel regulator of ESC-derived neural progenitors.
Stem Cells. 2011 29(2):193-205. doi: 10.1002/stem.567.