Professor Marysia Placzek
Professor in Developmental Neurobiology
Director MRC Centre for Developmental and Biomedical Genetics
Department of Biomedical Science
The University of Sheffield
Western Bank
Sheffield S10 2TN
United Kingdom
email : m.placzek@sheffield.ac.uk
Room: D226a Alfred Denny building
Telephone: +44 (0) 114 222 2353
Career history
- Deputy Director of the MRC Centre for Developmental and Biomedical Genetics, University of Sheffield (2007-present)
- 1999-present: Professor in Developmental Neurobiology, University of Sheffield
- 1997-1999: Senior Lecturer, University of Sheffield
- 1992-1997: Scientific Staff, National Institute of Medical Research, London
- 1983-1987: Post-doctoral fellow, Columbia University, New York. Research Advisor: Dr Jane Dodd.
- 1983-1987: PhD. Imperial Cancer Research Fund and Imperial College, London. Research Advisor: Dr Gordon Peters
- 1979-1983: Bsc, University of Edinburgh
Research interests
A major focus of our research is to understand the development of the vertebrate hypothalamus. We are aiming to characterise the signalling factor/transcription factor networks that mediate hypothalamic development, elucidate how hypothalamic stem cells progress into defined neuronal cells and how their axons project to different components of the hypothalamus. A second focus is the elucidation of the signalling factor/transcriptional networks that underlie development of the prechordal mesoderm.
Read more (link to the MRC Centre for Developmental and Biomedical Genetics)
Activities and distinctions
- Scientific Advisory Board member Roslin Institute (2008-2011)
Funding
Recent publications
Pearson CA, Ohyama K, Manning L, Aghamohammadzadeh S, Sang H, Placzek M.
FGF-dependent midline-derived progenitor cells in hypothalamic infundibular development.
Development. 2011 138:2613-24.
Van Hateren NJ, Das RM, Hautbergue GM, Borycki AG, Placzek M, Wilson SA.
FatJ acts via the Hippo mediator Yap1 to restrict the size of neural progenitor cell pools.
Development. 2011 138:1893-902.
Blackshaw S, Scholpp S, Placzek M, Ingraham H, Simerly R, Shimogori T.
Molecular pathways controlling development of thalamus and hypothalamus: from neural specification to circuit formation.
J Neurosci. 2010 30:14925-30. Review.
Placzek M.
Tissue recombinations in collagen gels.
Methods Mol Biol. 2008;461:325-35.
Ohyama K, Das R, Placzek M.
Temporal progression of hypothalamic patterning by a dual action of BMP.
Development. 2008; 135:3325-31