Dr Andrew Peden

Andrew Peden

Lecturer
Department of Biomedical Science
The University of Sheffield
Western Bank Sheffield
S10 2TN
United Kingdom

Tel: 0114 222 2312

Career history

2012-present: Lecturer
2006-2010: Principal Investigator, University of Cambridge (MRC Career Development Award).
2001-2005: Postdoctoral fellow, Genentech Inc.,.
2000-2001: Postdoctoral fellow, Stanford University (Wellcome Trust Research Fellowship).
1995-1999: PhD, University of Cambridge.
1991-1995: BSc., University of Edinburgh.

Research interests

Constitutive secretion is a conserved process required for the delivery of newly synthesised proteins and lipids to plasma membrane as well as the exocytocis of extracellular factors such as cytokines, lipoproteins and antibodies. My lab is interested in identifying and characterising the pathways and machinery involved in constitutive secretion. Read more on our research.

Current activities

Associate Editor for BMC Cell biology

Recent publications

Kent H.M., Evans P.R., Gray S.R., Sanderson C.M., Luzio J.P. *Peden A.A. and *Owen D.J.
Structural basis of the intracellular sorting of the SNARE VAMP7 by the AP-3 adaptor complex.
Dev Cell. In press.

Miller S.E., Sahlender D., Graham S., Hoening S., Robinson M.S. *Peden A.A and Owen D.J.
The Molecular Basis for the Endocytosis of Small R-SNAREs by the Clathrin AdaptorCALM.
2011 Cell. 147, 1118-1131.

Renna M., Schaffner C., Winslow A.R., Menziesv F. M., Peden A.A., Floto A. and Rubinsztein D.C.
Autophagic substrates clearance requires the activity of the Syntaxin-5 SNARE complex.
2011 J. Cell Science. 124, 469-82.

Bond L.M., Peden A.A., Kendrick-Jones J., Sellers, J.R., Buss F.
Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane.
2011 Mol. Bio. Cell. 22, 54-65.

Wislow A., Chen C.W., Corrochano S., Acevedo-Arozena A., Gorden, D.E, Peden A.A., Lichtenberg, M., Menzies, F.M., Ravikumar B., Imasrisio S., Brown S., O’Kane C. and Rubinsztein D.C.
Alpha-synuclein impairs macroautophagy: implications for Parkinson’s disease.
2010 J. Cell Biol. 190, 1023-37.

Jing J., Junutula J.R., Wu C., Burden J., Peden A.A. and Prekeris R.
FIP1/RCP Binding to Golgin-97 Regulates Retrograde Transport from Recycling Endosomes to Trans-Golgi Network.
2010 Mol. Biol. Cell. 21, 3041-53.

Gordon D.E., Bond L.M., Sahlender D.A. and Peden A.A.
A targeted siRNA screen to identify SNAREs required for constitutive secretion in mammalian cells.
2010 Traffic. 11, 1191-1204.

Roberts R.C, Peden A.A., Buss F., Bright N.A., Latouche-Hartmann M., Jessen J.R, Reilly M.M., Kendrick-Jones J., Luzio J.P.
Mistargeting of the recycling endosomal protein SH3TC2 causes Charcot-Marie-Tooth Disease Type 4C.
2010 Human Mol. Genetics. 19,1009-18.

Wendler F., Gillingham A.K., Sinka R., Franch-Marro X., Gordon D.E., Peden A.A., Vincent J.P and Munro S.
A genome-wide RNA interference screen identifies novel components of the metazoan secretory pathway.
2010 EMBO J. 29, 304-14.

Gordon D.E., Mirza M., Sahlender D.A, Jakovleska J. and Peden A.A.
Coiled-coil interactions are required for post-Golgi R-SNARE trafficking.
2009 EMBO Reports. 10, 851-856.