Professor Philip W. Ingham: Key Papers
Elworthy S, Hargrave M, Knight R, Mebus K, Ingham PW (2008)
Expression of multiple slow myosin heavy chain genes reveals a diversity of zebrafish slow twitch muscle fibres with differing requirements for Hedgehog and Prdm1 activity.
Development.
2008 May 14. [Epub ahead of print]
Flinn L, Bretaud S, Lo C, Ingham PW, Bandmann O (2008)
Zebrafish as a new animal model for movement disorders.
J Neurochem.
May 5. [Epub ahead of print]
Pagnon-Minot A, Malbouyres M, Haftek-Terreau Z, Kim HR, Sasaki T, Thisse C,, Thisse B, Ingham PW, Ruggiero F, Le Guellec D (2008)
Collagen XV, a novel factor in zebrafish notochord differentiation and
muscle development.
Dev Biol. 316(1):21-35.
Epub 2008 Jan 4.
Brunk K, Vernay B, Griffith E, Reynolds NL, Strutt D, Ingham PW, Jackson AP (2007)
Microcephalin coordinates mitosis in the syncytial Drosophila embryo.
J Cell Sci.
120(Pt 20):3578-88. Epub 2007 Sep 25.
Gray C, Packham IM, Wurmser F, Eastley NC, Hellewell PG, Ingham PW, Crossman DC, Chico TJ (2007)
Ischemia Is Not Required for Arteriogenesis in Zebrafish Embryos.
Arterioscler Thromb Vasc Biol.
Jul 26; [Epub ahead of print]
Moore CA, Parkin CA, Bidet Y, Ingham PW (2007)
A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion.
Development
134(17):3145-53. Epub 2007 Aug 1.
Svetic V, Hollway GE, Elworthy S, Chipperfield TR, Davison C, Adams RJ, Eisen JS, Ingham PW, Currie PD, Kelsh RN (2007)
Sdf1a patterns zebrafish melanophores and links the somite and melanophore pattern defects in choker mutants.
Development
134(5):1011-22. Epub 2007 Jan 31.
Bretaud S, Allen C, Ingham PW, Bandmann O (2007)
p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson’s disease.
J Neurochem
100(6):1626-35 [Epub December 2006]
Renhaw SA, Loynes CA, Trushell DM, Elworthy S, Ingham PW, Whyte MK
A transgenic zebrafish model of neutrophilic inflammation.
Blood
2006 Dec 15; 108(13):3976-8
Ingham PW, Kim HR.
Hedgehog signalling and the specification of muscle cell identity in the zebrafish embryo.
Exp Cell Res.
2005 Jun 10; 306(2):336-42
Tay SY, Ingham PW, Roy S.
A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo.
Development. Epub 2005 Jan 12.
2005 Feb;132(4):625-34.
Keegan BR, Feldman JL, Begemann G, Ingham PW, Yelon D.
Retinoic acid signaling restricts the cardiac progenitor pool.
Science.
2005 Jan 14;307(5707):247-9.
Wolff C, Roy S, Lewis KE, Schauerte H, Joerg-Rauch G, Kirn A, Weiler C, Geisler R, Haffter P, Ingham PW.
iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo.
Genes Dev.
2004 Jul 1;18 (13):1565-76. Epub 2004 Jun 15.
Nakano Y, Nystedt S, Shivdasani AA, Strutt H, Thomas C, Ingham PW.
Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila
Mech Dev.
2004 Jun;121 (6):507-18.
Nakano Y, Kim HR, Kawakami A, Roy S, Schier AF, Ingham PW. (2004)
Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo.
Dev Biol.
2004 May 15;269(2):381-92.
Thomas C, Ingham PW.
Hedgehog Signaling in the Drosophila Eye and Head. An analysis of the effects of different patched trans-heterozygotes.
Genetics.
2003 Dec;165(4):1915-28
Baxendale S, Davison C, Muxworthy C, Wolff C, Ingham PW, Roy S.
The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling.
Nat Genet.
2004 Jan;36(1):88-93.
Shivdasani AA, Ingham PW.
Regulation of stem cell maintenance and transit amplifying cell proliferation by tgf-beta signaling in Drosophila spermatogenesis.
Curr Biol.
2003 Dec 2;13(23):2065-72
Wolff C, Roy S, Ingham PW (2003).
Multiple Muscle Cell Identities Induced by Distinct Levels and Timing of Hedgehog Activity in the Zebrafish Embryo.
Current Biology
13:1169-1181.
Begemann, G., Schilling, TF., Rauch, GJ., Geisler, R., and Ingham, PW (2001).
The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain.
Development
128:3081-3094.
Roy, S., Wolff, C and Ingham, P.W. (2001).
The u-boot mutation identifies a Hedgehog regulated myogenic switch for fibre-type diversification in the zebrafish embryo.
Genes & Devl.
15:1563-1576.
Ingham, P.W., Nystedt, S., Brown, W., Nakano, Y., Stark, D., van den Heuvel, M. and Taylor, A.M (2000)
Patched Represses the Hedgehog Signalling Pathway by Promoting Processing of Smoothened protein.
Current Biology
10:1315-1318
Lewis KE, Currie PD, Roy S, Schauerte H, Haffter P and Ingham PW (1999)
Control of muscle cell-type specification in the zebrafish embryo by Hedgehog signalling.
Dev Biol.
216: 469-80 441-60
Blagden CS, Currie PD, Ingham PW, Hughes SM
Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog.
Genes Dev.
1997 Sep 1;11(17):2163-2175
Chang BE, Blader P, Fischer N, Ingham PW, Strahle U
Axial (HNF3beta) and retinoic acid receptors are regulators of the zebrafish sonic hedgehog promoter.
EMBO J.
1997 Jul 1;16(13):3955-3964
Alexandre C, Jacinto A, Ingham PW.
Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.
Genes Dev.
1996 Aug 15;10(16):2003-13.
van den Heuvel M, Ingham PW.
smoothened encodes a receptor-like serpentine protein required for hedgehog signalling.
Nature. 1996 Aug 8;382(6591):547-51.
1996 Aug 8;382(6591):547-51.
Currie PD, Ingham PW.
Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish.
Nature.
1996 Aug 1;382(6590):452-5.
Forbes AJ, Lin H, Ingham PW, Spradling AC.
hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila.
Development.
1996 Apr;122(4):1125-35.
Ingham PW, Fietz MJ.
Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing.
Curr Biol.
1995 Apr 1;5(4):432-40.
Krauss S, Concordet JP, Ingham PW.
A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos.
Cell.
1993 Dec 31;75(7):1431-44.
Ingham PW.
Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo.
Nature.
1993 Dec 9;366(6455):560-2.
Ingham PW, Hidalgo A.
Regulation of wingless transcription in the Drosophila embryo.
Development.
1993 Jan;117(1):283-91.
Forbes AJ, Nakano Y, Taylor AM, Ingham PW.
Genetic analysis of hedgehog signalling in the Drosophila embryo.
Dev Suppl.
1993;:115-24.
Ingham PW, Taylor AM, Nakano Y.
Role of the Drosophila patched gene in positional signalling.
Nature.
1991 Sep 12;353(6340):184-7.
Hidalgo A, Ingham P.
Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched.
Development.
1990 Sep;110(1):291-301.
Phillips RG, Roberts IJ, Ingham PW, Whittle JR.
The Drosophila segment polarity gene patched is involved in a position-signalling mechanism in imaginal discs.
Development.
1990 Sep;110(1):105-14.
Nakano Y, Guerrero I, Hidalgo A, Taylor A, Whittle JR, Ingham PW.
A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched.
Nature.
1989 Oct 12;341(6242):508-13.
Howard K, Ingham P, Rushlow C.
Region-specific alleles of the Drosophila segmentation gene hairy.
Genes Dev.
1988 Aug;2(8):1037-46.
Martizez Arias A, Baker NE, Ingham PW.
Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo.
Development.
1988 May;103(1):157-70.
Ingham PW, Baker NE, Martinez-Arias A.
Regulation of segment polarity genes in the Drosophila blastoderm by fushi tarazu and even skipped.
Nature.
1988 Jan 7;331(6151):73-5.
Ingham PW, Martinez-Arias A.
The correct activation of Antennapedia and bithorax complex genes requires the fushi tarazu gene.
Nature.
1986 Dec 11-17;324(6097):592-7.
Macdonald PM, Ingham P, Struhl G.
Isolation, structure, and expression of even-skipped: a second pair-rule gene of Drosophila containing a homeo box.
Cell.
1986 Dec 5;47(5):721-34.
Howard K, Ingham P.
Regulatory interactions between the segmentation genes fushi tarazu, hairy, and engrailed in the Drosophila blastoderm.
Cell.
1986 Mar 28;44(6):949-57.