Professor Philip W. Ingham FRS FMedSci HonFRCP

MRC Centre for Developmental and Biomedical Genetics
The University of Sheffield
Western Bank
Sheffield S10 2TN
United Kingdom

email : p.w.ingham@sheffield.ac.uk

Room: D32a Firth Court

Telephone: +44 (0) 114 222 2710 (Personal Assistant)
Fax: +44 (0) 114 276 5413

Research Interests

A major aim of our research is to understand the molecular basis of the differential response of cells to Hedgehog signaling and to characterize the divergence in the signaling pathway between different species. A second focus is the elucidation of the transcriptional networks underlying the development of skeletal muscle in the zebrafish. We use a variety of approaches, including transgenesis, in vivo imaging, ChIP and proteomic analysis.

Read more on research in the Ingham laboratory

Career History:

• Deputy Director of the Institute of Molecular and Cell Biology, Singapore (2007-)
• EMBO member (1995) Fellow of Academy of Medical Sciences (2001) Fellow Royal Society (2002)
• 1996 to date: Director of the MRC Centre for Developmental and Biomedical Genetics, Professor of Developmental Genetics, University of Sheffield
• 1994-1996: Principal Scientist, Imperial Cancer Research Fund, London
• 1986-1994: Research Scientist/Senior Scientist, ICRF Developmental Biology Unit, Oxford
• 1986: Research Scientist, Laboratory of Molecular Biology, Medical Research Council, Cambridge
• 1982-1985: Post doctoral research assistant, ICRF, Mill Hill, London
• 1981-1985: Royal Society European Exchange Fellow, LGME du CNRS, Strasbourg, France

Activities and Distinctions

• International Scientific Advisory Board Member Max Planck Institute for Developmental Biology, Tübingen, The Sars International Centre for Marine Biology (Bergen), the Karolinska Institute Centre of Excellence in Developmental Biology (Stockholm) and the Wellcome Trust Sanger Institute (Hinxton)
• Medal of the Genetics Society of Great Britain, 2005
• Editorial Advisor Board member: Developmental Cell, Current Biology, EMBO Journal
• Fellow of the Royal Society, Academy of Medical Science; Honorary Fellow of the Royal College of Physicians

Grants

• MRC (£2,383,148) Centre for Developmental and Biomedical Genetics (October 2007 to September 2012)
• Wellcome Trust (£1,242,139) Hedgehog signaling in zebrafish” Functional analysis of the pathway components (October 2007 to September 2012)
• CRUK (£105,353) Establishment of a novel transgenic zebrafish tumour model to visualize blood flow in tumours and the effects of vascular disrupting agents (2007 to 2009)
• EU Framework 6 Network of Excellence (£231,535) MYORES: Multi organismic approach to study normal and aberrant muscle development, function and repair (January 2005 to December 2009)
• Wellcome Trust (£172,642) Analysis of the role of the zebrafish Iguana gene in hedgehog signaling (September 2004 to February 2008)
• EU Framework 6 Network of Excellence (£345,175) Cells into Organs: Functional genomics for development and disease of mesodermal organ systems (April 2004 to March 2009)
• EU Framework 6 Network of Excellence (£445,275) ZF Models: Zebrafish models for human development and disease (January 2004 to December 2008)

Key publications since 2001

• Elworthy S, Hargrave M, Knight R, Mebus K, Ingham PW (2008)
  Expression of multiple slow myosin heavy chain genes reveals a diversity of zebrafish slow twitch muscle fibres with differing requirements for Hedgehog and Prdm1 activity.
  Development. 2008 May 14.[Epub ahead of print]
• Flinn L, Bretaud S, Lo C, Ingham PW, Bandmann O (2008)
  Zebrafish as a new animal model for movement disorders.
  J Neurochem. May 5. [Epub ahead of print]
• Pagnon-Minot A, Malbouyres M, Haftek-Terreau Z, Kim HR, Sasaki T, Thisse C, Thisse B, Ingham PW, Ruggiero F, Le Guellec D (2008)
  Collagen XV, a novel factor in zebrafish notochord differentiation and
  muscle development.
  Dev Biol. 316(1):21-35. Epub 2008 Jan 4.
• Ingham PW. (2008)
  Hedgehog signalling.
  Curr Biol. 18(6):R238-41.
• Parkin CA, Ingham PW (2007)
  The adventures of Sonic Hedgehog in development and repair. I. Hedgehog
  signaling in gastrointestinal development and disease.
  Am J Physiol Gastrointest Liver Physiol.
  294(2):G363-7. Epub 2007 Dec 6.
• Brunk K, Vernay B, Griffith E, Reynolds NL, Strutt D, Ingham PW, Jackson AP (2007).
  Microcephalin coordinates mitosis in the syncytial Drosophila embryo.
  J Cell Sci. 120(Pt 20):3578-88. Epub 2007 Sep 25.
• Roy S, Wolff C and Ingham PW (2001).
  The u-boot mutation identifies a Hedgehog regulated myogenic switch for fibre-type diversification in the zebrafish embryo.
  Genes & Devl. 15:1563-1576.
• Parkin CA, Ingham PW (2007).
  Hedgehog Signalling in Gastrointestinal Development and Disease.
  Am J Physiol Gastrointest Liver Physiol. Dec 6; [Epub ahead of print]
• Renshaw SA, Loynes CA, Elworthy S, Ingham PW, Whyte MK (2007).
  Modeling inflammation in the zebrafish: how a fish can help us understand lung disease.
  Exp Lung Res. 33(10):549-54.
• Gray C, Packham IM, Wurmser F, Eastley NC, Hellewell PG, Ingham PW, Crossman DC, Chico TJ (2007).
  Ischemia Is Not Required for Arteriogenesis in Zebrafish Embryos.
  Arterioscler Thromb Vasc Biol. Jul 26; [Epub ahead of print]
• Ingham PW McMahon AP (2001)
  Hedgehog signaling in animal development: paradigms and principles.
  Genes Dev. 15(23):3059-87
• Begemann G, Schilling TF, Rauch GJ, Geisler R, and Ingham PW (2001).
  The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain.
  Development 128:3081-3094.
• Moore CA, Parkin CA, Bidet Y, Ingham PW (2007).
  A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion.
  Development
  134(17):3145-53. Epub 2007 Aug 1.
• Svetic V, Hollway GE, Elworthy S, Chipperfield TR, Davison C, Adams RJ, Eisen JS, Ingham PW, Currie PD, Kelsh RN (2007).
  Sdf1a patterns zebrafish melanophores and links the somite and melanophore pattern defects in choker mutants.
  Development 134(5):1011-22. Epub 2007 Jan 31.
• Bretaud S, Allen C, Ingham PW, Bandmann O (2007)
  p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson’s disease.
  J Neurochem 100(6):1626-35 [Epub December 2006]
• Ingham PW, Placzek M (2006)
  Orchestrating ontogenesis: variations on a theme by sonic hedgehog.
  Nat Rev Genet. 7(11):841-50
• Renhaw SA, Loynes CA, Trushell DM, Elworthy S, Ingham PW, Whyte MK (2006)
  A transgenic zebrafish model of neutrophilic inflammation.
  Blood 108(13):3976-8
• Keegan BR, Feldman JL, Begemann G, Ingham PW, Yelon D (2005).
  Retinoic acid signaling restricts the cardiac progenitor pool.
  Science. 307(5707):247-9.
• Tay SY, Ingham PW, Roy S (2005)
  A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo.
  Development. Epub 2005 Jan 12.
  132(4):625-34.
• Ingham PW, Kim HR (2005).
  Hedgehog signalling and the specification of muscle cell identity in the zebrafish embryo.
  Exp Cell Res. 306(2):336-42
• Nakano Y, Kim HR, Kawakami A, Roy S, Schier AF, Ingham PW. (2004)
  Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo.
  Dev Biol. 269(2):381-92.
• Nakano Y, Nystedt S, Shivdasani AA, Strutt H, Thomas C, Ingham PW (2004).
  Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila.
  Mech Dev. 121 (6):507-18.
• Wolff C, Roy S, Lewis KE, Schauerte H, Joerg-Rauch G, Kirn A, Weiler C, Geisler R, Haffter P, Ingham PW (2004).
  iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo.
  Genes Dev. 18 (13):1565-76. Epub 2004 Jun 15.
• Baxendale S, Davison C, Muxworthy C, Wolff C, Ingham PW, Roy S (2004).
  The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling.
  Nat Genet. 36(1):88-93.
• Shivdasani AA and Ingham PW (2003).
  Regulation of stem cell maintenance and transit amplifying cell proliferation by tgf-beta signaling in Drosophila spermatogenesis.
  Curr Biol. 13(23):2065-72
• Thomas C and Ingham PW (2003).
  Hedgehog Signaling in the Drosophila Eye and Head. An analysis of the effects of different patched trans-heterozygotes.
  Genetics 165(4):1915-28
• McMahon AP, Ingham PW and Tabin CJ. (2003)
  Developmental roles and clinical significance of hedgehog signaling.
  Curr Top Dev Biol. 53:1-114
• Anderson KV and Ingham PW (2003).
  The transformation of the model organism: a decade of developmental genetics.
  Nat Genet. 33 Suppl:285-93
• Wolff C, Roy S, Ingham PW (2003).
  Multiple Muscle Cell Identities Induced by Distinct Levels and Timing of Hedgehog Activity in the Zebrafish Embryo.
  Current Biology 13:1169-1181.
• Roy S and Ingham PW. (2002)
  Hedgehogs tryst with the cell cycle.
  J Cell Sci. 115(Pt 23):4393-7
• Strutt H, Thomas C, Nakano Y, Stark D, Neave B, Taylor AM and Ingham PW (2001)
  Mutations in the Sterol Sensing Domain of Patched suggest a Role for Vesicular Trafficking in Smoothened Regulation.
  Current Biology. 11: 608-613

View a full list of Philip Ingham's publications