Professor Matthew Holley

Matthew

Professor of Sensory Physiology
Department of Biomedical Science
The University of Sheffield
Western Bank
Sheffield S10 2TN
United Kingdom

email : m.c.holley@sheffield.ac.uk
Room: B1 218 Alfred Denny building
Telephone: +44 (0) 114 222 2374

Career history

2001-present: Professor of Sensory Physiology, University of Sheffield
2006-2012: Head of Department
2000-2001: Reader, Department of Physiology, University of Bristol
1990-2000: Royal Society University Research Fellow, Department of Physiology, University of Bristol
1988-1990: Beit Memorial Research Fellow, Department of Physiology, University of Bristol
1986-1988: Post-doctoral Research Associate (MRC), Department of Physiology, University of Bristol
1985-1986: Brown Junior Research Fellow, The Queen's College, University of Oxford
1984-1985: Royal Society European Exchange Programme Fellow, Department of Cell Biology, University of Stockholm, Sweden
1983: D.Phil - University of Oxford
1982-1984: Brown Junior Research Fellow, The Queen's College, University of Oxford
1979-1982: Postgraduate Research Student, Department of Zoology, University of Oxford
1979: BSc.Hons - University of Newcastle-upon-Tyne

Research interests

I am primarily interested in the development and function of the mammalian inner ear with a focus on potential treatments for hearing loss. I have developed in vitro models for the differentiation of sensory hair cells and sensory nerves and use them in conjunction with microarrays to study gene networks centred on the transcription factor Gata3. I have also explored a model system for cell transplantation into the inner ear in vivo. Read more on research in the Holley laboratory

Activities and distinctions

Senate Award for Departmental Leadership in Learning and Teaching
Trustee of the Action on Hearing Loss
Graham Fraser Memorial Lecturer – Royal Society of Medicine, London, 2010

Funding

Recent publications

Lin Z, Perez P, Sun Z, Liu JJ, Shin JH, Hyrc KL, Samways D, Egan T, Holley MC, Bao J. (2012)
Reprogramming of single-cell-derived mesenchymal stem cells into hair cell-like cells.
Otol Neurotol. [Epub ahead of print]

Zetes D, Tolomeo J & Holley MC (2012)
Structure and mechanics of supporting cells in the guinea pig organ of Corti.
PLoS ONE 7(11): e49338. doi:10.1371/journal.pone.0049338

Eckrich T, Varakina K, Johnson S, Franz C, Singer W, Kuhn S, Knipper M, Holley M, Marcotti W (2012)
Development and Function of the Voltage-Gated Sodium Current in Immature Mammalian Cochlear Inner Hair Cells.
PLoS ONE 7(9): e45732. doi:10.1371/journal.pone.0045732

Zampini V, Rüttiger L, Johnson S, Franz C, Furness DN, Waldhaus J, Xiong H, Hackney CM, Holley MC, Offenhauser N, Di Fiore PP, Knipper M, Masetto S & Marcotti W.
Eps8 Regulates Hair Bundle Length and Functional Maturation of Mammalian Auditory Hair Cells.
PloS Biology 2011 Apr;9(4):e1001048.

Kuhn S, Johnson SL, Furness DN, Chen J, Ingham N, Hilton JM, Steffes G, Lewis MA, Zampini V, Hackney CM, Masetto S, Holley MC, Steel KP & Marcotti W.
miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells.
Proc Natl Acad Sci USA 108:2355-60.

Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Hossain MA, Suzuki A, Holley MC, Tokuda M.
Phosphatase and tensin homolog deleted on chromosome 10 regulates sensory cell proliferation and differentiation of hair bundles in the mammalian cochlea.
Neuroscience. 2010. 170:1304-13.

Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Suzuki A, Holley M, Tokuda M.
Role of phosphatase and tensin homolog in the development of the mammalian auditory system.
Neuroreport. 2010 Jul 14;21(10):731-5.

Honkela A, Milo M, Holley M, Rattray M, Lawrence ND
Ranking of gene regulators through differential equations and Gaussian processes.
Proceedings of 2010 IEEE International Workshop on Machine Learning for Signal Processing.

Sekiya T, Matsumoto M, Kojima K, Ono K, Kikkawa Y, Kada S, Ogita H, Horie R, Viola A, Holley M, Ito J
Mechanical stress-induced reactive gliosis in the auditory nerve and cochlear nucleus;
J Neurosurg. 2010 Apr 2. [Epub ahead of print]

Holley M, Rhodes C, Kneebone A, Herde MK, Fleming M, Steel KP
Emx2 and early hair cell development in the mouse inner ear.
Dev Biol. Feb 9. 2010 [Epub ahead of print]

Sanchez-Calderon H, Rodriguez-de la Rosa L, Milo M, Pichel JG, Holley M, Varela-Nieto I
RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors.
PLoS One, 2010 5:e8699.

Milo M, Cacciabue-Rivolta D, Kneebone A, Van Doorninck H, Johnson C, Lawoko-Kerali G, Niranjan M, Rivolta M, Holley M.
Genomic analysis of the function of the transcription factor gata3 during development of the mammalian inner ear.
PLoS One, 2009 4:e7144.