Dr Andrew Furley
Senior Lecturer & Postgraduate Research Director
Department of Biomedical Science
The University of Sheffield
Sheffield S10 2TN
email : email@example.com
Room: D231 Alfred Denny building
Telephone: +44 (0) 114 222 2354
- 2004-present: Senior Lecturer, Biomedical Science, University of Sheffield
- 1997-2004: Lecturer, CDBG, Biomedical Science, University of Sheffield
- 1992-1997: MRC Research Scientist, Division of Developmental Neurobiology, NIMR, Mill Hill, London
- 1990-1992: Howard Hughes Medical Institute Fellow, Center for Neurobiology & Behavior, Columbia University, New York (Advisor: T. Jessell)
- 1987-1990: Jane Coffin Childs Post-Doctoral Fellow, Dept of Biochemistry, Columbia University, New York (Advisors:F. Alt/T. Jessell)
- 1987: PhD Leukaemia Biology, Imperial Cancer Research/UCL, London (Supervisor: M. Greaves)
- 1982: B.Sc. (Hons) Molecular Biology, University of Edinburgh
Our research is focussed on the role L1CAM-like cell adhesion molecules (L1-CNTNs) in neural development. L1-CNTNs affect neural function at all stages, including the earliest proliferation and differentiation of progenitor and stem cells (Bizzoca et al 2003; Ma et al 2008; Xenaki et al., 2011; Bizzoca et al., 2012), the guidance of axons (Cohen et al 1998; Law et al 2008; Dang et al., 2012), through to firing of action potentials (Poliak et al 2003) and functioning of synapses (Bliss et al 2000). As a result, these molecules are widely implicated in neurological disease and cancers. Our aim is to understand the cellular mechanisms through which L1-CNTNs affect this wide variety of processes.
Activities and distinctions
- British Society for Developmental Biology (BSDB; www.bsdb.org) Committee member (1999-2005); Publications Secretary (2000-2005; http://www.bms.ed.ac.uk/services/webspace/bsdb/BSDBnewsold.htm
- MRC Advisory Board (MAB) 2002-2005
- Appointed adviser on genetics and biotechnology to EU-wide consortium (PRIVILEGED) determining the ethical and legal interests in privacy and data protection for research involving the use of genetic databases and bio-banks, 2007. www.privilegedproject.eu
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Cancer Research UK
- Human Frontiers Science Program (HFSP)
- Yorkshire Cancer Research
F3/Contactin acts as a modulator of neurogenesis during cerebral cortex development.
Dang, P., Smythe, E., and Furley, A. J. (2012).
Buchner, D. A., Geisinger, J. M., Glazebrook, P. A., Morgan, M. G., Spiezio, S. H., Kaiyala, K. J., Schwartz, M. W., Sakurai, T., Furley, A. J., Kunze, D. L., Croniger, C. M., and Nadeau, J. H. (2012).
Xenaki D, Martin IB, Yoshida L, Ohyama K, Gennarini G, Grumet M, Sakurai T, Furley AJ.
Law CO, Kirby RJ, Aghamohammadzadeh S, Furley AJ.
Dawe, G. S., Ma, Q. H., Futagawa, T., Yang, W. L., Jiang, X. D., Zeng, L., Takeda, Y., Xu, R. X., Bagnard, D., Schachner, M., Furley, A. J., Karagogeos, D., Watanabe, K., and Xiao, Z. C. (2008).
Ma QH, Futagawa T, Yang WL, Jiang XD, Zeng L, Takeda Y, Xu RX, Bagnard D, Schachner M, Furley AJ, Karagogeos D, Watanabe K, Dawe GS, Xiao ZC.