Professor Elizabeth Smythe
Professor of Molecular Cell Biology
Department of Biomedical Science
The University of Sheffield
Western Bank
Sheffield S10 2TN
United Kingdom
email : e.smythe@sheffield.ac.uk
Room: C09 Florey building
Telephone: +44 (0) 114 222 4635
Career history
- 2002-present: Professor of Molecular Cell Biology, University of Sheffield
- 1992-2002: MRC Senior Fellow and Principal Investigator, Wellcome Trust BioCentre, University of Dundee
- 1989-1992: NATO/SERC postdoctoral fellow, The Scripps Research Institute, California
- 1986-1989: Postdoctoral research assistant, University of Dundee.
- 1986: PhD, Trinity College, Dublin
- 1982: B.A. (Mod), Trinity College, Dublin
Research interests
Our lab is interested in the molecular mechanisms of cargo sorting along the endocytic pathway with particular emphasis on the regulation of the clathrin coated vesicle cycle by rab5 and reversible phosphorylation. We are also interested in the interplay between endocytic trafficking and signaling pathways.
Read more on research in the Smythe laboratory
Current activities
Member of:
- the Faculty of 1000 (2001-)
- the Editorial Board of the Biochemical Journal (2004-2007) Renewed (2007-2011)
- the MRC College of Experts (2006-2010)
- Executive Secretary of the British Society for Cell Biology (2006-2011)
Funding
Recent publications
Montagnac G, de Forges H, Smythe E, Gueudry C, Romao M, Salamero J, Chavrier P.
Decoupling of activation and effector binding underlies ARF6 priming of fast endocytic recycling.
Curr Biol. 2011 21:574-9.
Vidal OM, Stec W, Bausek N, Smythe E, Zeidler MP.
Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking.
J Cell Sci. 2010 123:3457-66. Epub 2010 Sep 14.
Robertson AS, Smythe E, Ayscough KR.
Functions of actin in endocytosis.
Cell Mol Life Sci. 2009 Jul;66(13):2049-65. Epub 2009 Mar 17. Review.
Semerdjieva S, Shortt B, Maxwell E, Singh S, Fonarev P, Hansen J, Schiavo G, Grant BD, Smythe E.
Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6.
J Cell Biol. 2008 183(3):499-511.
Parker LC, Prestwich EC, Ward JR, Smythe E, Berry A, Triantafilou M, Triantafilou K, Sabroe I.
A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains.
J Immunol. 2008 181(8):5606-17.