Professor Carl Smythe

Department of Biomedical Science
The University of Sheffield
Western Bank
Sheffield S10 2TN
United Kingdom

Professor of Cell Biology
Room: C106 Addison building
Telephone: +44 (0) 114 222 4643

email : c.g.w.smythe@sheffield.ac.uk

Career history

• 2002 – present: Professor of Cell Biology, Department of Biomedical Science, University of Sheffield
• 2004 – 2006: Head of Department, Department of Biomedical Science, University of Sheffield
• 1992 – 2002: Principal Investigator at MRC Protein Phosphorylation Unit, University of Dundee
• 1989 – 1992: American Cancer Society Senior Research Fellow, University of California, San Diego
• 1985 – 1989: British Diabetic Association postdoctoral research assistant at MRC Protein Phosphorylation Group at University of Dundee
• 1981 – 1985: PhD Department of Biochemistry, Trinity College, University of Dublin

Research interests

Chromosome Integrity - Chromosomes in eukaryotes control their environment to ensure that genomic integrity is maximised. We are interested in understanding mechanisms of genomic integrity operating at the molecular and cellular level, and determining the consequences when they fail.

Read more on research in the Smythe laboratory

Funding

• Association for International Cancer Research
• Breast Cancer Campaign
• Cancer Research UK
• MRC
• Wellcome Trust

Recent publications

• Bishop A, Lane R, Beniston R, Chapa-y-Lazo B, Smythe C, Sudbery P.
  Hyphal growth in Candida albicans requires the phosphorylation of Sec2 by the Cdc28-Ccn1/Hgc1 kinase.
  EMBO J. 2010 29:2930-42. Epub 2010 Jul 16.
• Gill, M.R., J. Garcia-Lara, S. Foster, C. Smythe, G. Battaglia, and J. Thomas.
  A ruthenium(II) polypyridyl complex for direct imaging of DNA structure in living cells.
  Nature Chemistry 2010. 1: 662-667.
• Salpingidou G, Rzepecki R, Kiseleva E, Lyon C, Lane B, Fusiek K, Golebiewska A, Drummond S, Allen T, Ellis JA, Smythe C, Goldberg MW, Hutchison CJ.
  NEP-A and NEP-B both contribute to nuclear pore formation in Xenopus eggs and oocytes.
  J Cell Sci. 2008. 121(Pt 5):706-16.
• Müller B, Blackburn J, Feijoo C, Zhao X, Smythe C.
  DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication.
  J Cell Biol. 2007. 179(7):1385-98.